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이소하 교수

Lee So Ha

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  • 소속캠퍼스한국과학기술연구원 스쿨
  • 전공 바이오-메디컬 융합
    (생물화학)
  • 연락처02-958-6834
  • 출신전공유기화학
  • 학위박사
  • 최종출신대학고려대학교
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연구분야

의약화학

Medicinal Chemistry

대표연구실적

-  Ibrahim Mustafa El-Deeb, Kyung Ho Yoo, So Ha Lee*, ROS receptor tyrosine kinase: a new potential target for anticancer drugs, Medicinal Research Reviews, 2011, 31(5), 794-818 -  Sang -Won Hong, Kyung Hee Jung, Myung -Joo Choi, Da Young Kim, Hee-Seung Lee, Hong -Mei Zheng, Guang Yong Li, Ibrahim M. El-Deeb, Byung Sun Park, So Ha Lee* and Soon-Sun Hong*, Anticancer effects of KI-10F: A novel compound affecting apoptosis, angiogenesis and cell growth in colon cancer, Int. J. Oncol. 2012, 41(5), 1715-1722. -  이소하외 8인, Ros 카이네이즈 저해 활성을 갖는 피라졸 화합물, 미국특허등록번호 8273880, 2012년 9월 25일

논문(최근 5년)

-  Structure-based optimization and biological evaluation of trisubstituted pyrazole as a core structure of potent ROS1 kinase inhibitors[Bioorganic & medicinal chemistry,2014-08-01] -  Optimization of Bipyridinyl Pyrazole Scaffolds via Design, Synthesis and Screening of a New Series of ROS1 Kinase-modulating Compounds[Bulletin of the Korean Chemical Society,2015-01-01] -  Synthesis and biological evaluation of new pyrazol-4-ylpyrimidine derivatives as potential ROS1 kinase inhibitors[European journal of medicinal chemistry,2015-01-01] -  Synthesis and in Vitro Screening of Phenylbipyridinylpyrazole[Molecules,2015-01-01] -  ROS1 amplification mediates resistance to Gefitinib in glioblastoma multiforme cells[Oncotarget,2015-05-01] -  Synthesis and biological evaluation of new pyrimidine-4-yl-ethanol derivatives as ROS1 kinase inhibitors[Journal of enzyme inhibition and medicinal chemistry,2015-05-01] -  Synthesis of Quinolinylaminopyrimidines and Quinazolinylmethylaminopyrimidines with Antiproliferative Activity against Melanoma Cell Line [Journal of enzyme inhibition and medicinal chemistry,2015-08-01] -  ROS1 Kinase Inhibitors for Molecular-Targeted Therapies[Current medicinal chemistry,2016-02-01] -  Synthesis of new diarylamides with pyrimidinyl pyridine scaffold and evaluation of their anti-proliferative effect on cancer cell lines[Bioorganic & medicinal chemistry letters,2016-02-01] -  Synthesis of novel arylaminoquinazolinylurea derivatives and their antiproliferative activities against bladder cancer cell line[ BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2016-10-01]

특허(최근 5년)

-  비정상 세포 성장 질환의 치료를 위한 단백질 키나아제 저해제인신규인다졸유도체,이의약학적으로 허용가능한 염 및 이를 유효성분으로 함유하는 약학적 조성물[2014-05-09] -  ROS 카이네이즈 저해활성을 갖는 2,4,6-삼치환된 피리미딘 화합물 [2015-09-22] -  비정상 세포 성장 질환의 치료를 위한 단백질 키나아제 저해제인신규인다졸유도체,이의약학적으로 허용가능한 염 및 이를 유효성분으로 함유하는 약학적 조성물[2014-06-17]