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이철주 교수

Cheolju Lee

INFO

  • 소속캠퍼스한국과학기술연구원 스쿨
  • 전공 바이오-메디컬 융합
    (생물화학)
  • 연락처02-958-6788
  • 출신전공생물리학
  • 학위박사
  • 최종출신대학서울대학교
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연구분야

생화학, 생물물리학, 단백체학, 질량분석

biochemistry, biophysics, proteomics, mass spectrometry

대표연구실적

-  Both targeted mass spectrometry and flow sorting analysis methods detected the decreased serum apolipoprotein e level in Alzheimer's disease patients. Mol Cell Proteomics. 2014 Feb;13(2):407-19 -  Quantitative analysis of mTRAQ-labeled proteome using full MS scans. J Proteome Res. 2010 Jul 2;9(7):3750-8 -  Identification of S100A8 and S100A9 as serological markers for colorectal cancer. J Proteome Res. 2009 Mar;8(3):1368-79

논문(최근 5년)

-  Discovery of melanotransferrin as a serological marker of colorectal cancer by secretome analysis and quantitative proteomics[Journal of proteome research,2014-11-01] -  Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in Caenorhabditis elegans[Proceedings of the National Academy of Sciences of the United States of America,2014-10-01] -  Identification of vinculin as a potential plasma marker for age-related macular degeneration[Investigative ophthalmology & visual science,2014-11-01] -  mTRAQ-based quantitative analysis combined with peptide fractionation based on cysteinyl peptide enrichment[Analytical biochemistry,2015-05-01] -  Use of composite protein database including search result sequences for mass spectrometric analysis of cell secretome[PLoS ONE ,2015-03-01] -  Dimer of arfaptin 2 regulates NF-κB signaling by interacting with IKKβ/ NEMO and inhibiting IKKβkinase activity[Cellular signalling,2015-11-01] -  Evaluation of Multi-tRNA Synthetase Complex by Multiple Reaction Monitoring Mass Spectrometry Coupled with Size Exclusion Chromatography[PLoS ONE ,2015-11-01] -  Identification of ganglioside GM2 activator playing a role in cancer cell migration through proteomic analysis of breast cancer secretomes[Cancer Science,2016-06-01] -  FGF11 induced by hypoxia interacts with HIF-1α and enhances its stability[ FEBS LETTERS,2017-02-01] -  Structural Basis of Novel Iron-Uptake Route and Reaction Intermediates in Ferritins from Gram-Negative Bacteria[JOURNAL OF MOLECULAR BIOLOGY,2016-12-04] -  Aldehyde dehydrogenase is used by cancer cells for energy metabolism[Experimental and Molecular Medicine,2016-11-25] -  Infection-specific phosphorylation of glutamyl-prolyl tRNA synthetase induces antiviral immunity[Nature Immunology,2016-11-01] -  A proteogenomic approach for protein-level evidence of genomic variants in cancer cells[Scientific Reports,2016-10-13] -  Proteomics-based identification and validation of novel plasma biomarkers phospholipid transfer protein and mannan-binding lectin serine protease-1 in age-related macular degeneration[Scientific Reports,2016-09-08] -  Aldehyde dehydrogenase inhibition combined with phenformin treatment reversed NSCLC through ATP depletion[Oncotarget,2016-08-02] -  NME1L Negatively Regulates IGF1-Dependent Proliferation of Breast Cancer Cells[Journal of Cellular Biochemistry,2016-06-01] -  CHIP controls necroptosis through ubiquitylation- and lysosome-dependent degradation of RIPK3[Nature Cell Biology,2016-03-01] -  Comprehensive Analysis of Low-Molecular-Weight Human Plasma Proteome Using Top-Down Mass Spectrometry[Journal of Proteome Research,2016-01-04] -  Role of Angiomotin-like 2 mono-ubiquitination on YAP inhibition[EMBO Reports,2016-01-01] -  Development and Validation of a Novel Plasma Protein Signature for Breast Cancer Diagnosis by Using Multiple Reaction Monitoring-based Mass Spectrometry[Anticancer Research,2015-11-01] -  SERBP1 affects homologous recombination-mediated DNA repair by regulation of CtIP translation during S phase[Nucleic Acids Research,2015-06-27] -  PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis[Nature Communications,2015-06-17] -  Impact of data-dependent exclusion list based mass spectrometry on label-free proteomic quantification[Rapid Communications in Mass Spectrometry,2015-01-15] -  High expression of AT-rich interactive domain 3A (ARID3A) is associated with good prognosis in colorectal carcinoma[Annals of Surgical Oncology,2014-12-01] -  Detection and quantification of plasma amyloid-β by selected reaction monitoring mass spectrometry[Analytica Chimica Acta,2014-08-20] -  A splicing variant of NME1 negatively regulates NF-κB signaling and inhibits cancer metastasis by interacting with IKKβ[Journal of Biological Chemistry,2014-06-20] -  The structural basis for the negative regulation of thioredoxin by thioredoxin-interacting protein[Nature Communications,2014-05-01] -  Identification of plasma membrane glycoproteins specific to human glioblastoma multiforme cells using lectin arrays and LC-MS/MS[Proteomics,2018-01-01]

특허(최근 5년)

-  나이관련황반변성(age-related macular degeneration(AMD)) 진단용 단백질 마커 빈쿨린[2015-01-20] -  벤조아릴우레이도 화합물, 및 이를 함유하는 퇴행성 뇌질환 예방 또는 치료용 조성물[2014-11-21] -  벤조아릴우레이도 화합물, 및 이를 함유하는 퇴행성 뇌질환 예방 또는 치료용 조성물[2015-04-21] -  BCHE를 비소세포 폐암 진단용 혈액학적 마커로 사용하는 방법[2017-11-02] -  인터넷·게임 중독 진단용 neuropilin-2 바이오마커 및 이의 검출용 조성물 [2018-01-09]