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Nam Ghilsoo

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  • 소속캠퍼스한국과학기술연구원 스쿨
  • 전공 바이오-메디컬 융합
    (생물화학)
  • 연락처02-958-5165
  • 출신전공유기화학
  • 학위박사
  • 최종출신대학서울대학교
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연구분야

의약화학, 유기화학

Medicinal Chemistry, Organic Chemistry,

대표연구실적

-  1. H. N. Shin, S. H. Seo, H. Choo, G. Kuem, K. I. Choi, and G. Nam* “Synthesis and antibacterial activities of new piperidine substituted(5R)-[1,2,3]triazolylmethyl and (5R)-[(4-F-[1,2,3]triazolyl)methyl]oxazolidinones” Bioorg. Med. Chem. Lett. 2013, 23, 1193-1196. -  2. J. Kim, J. Lee, B. Moon, I. M. Jung, G. Nam, G. Keum, A. N. Pae, H. Choo “ Pyridyl-urea Derivatives as blockers of A?-induced mPTP opening for Alzheimer’s disease” Korea. Bull. Chem. Soc. 2012, 33(11), 3887-3888. -  6. V.N. Devegowda, J. H. Kim,a K-C. Han, E. G. Yang, H. Choo, A. N. Pae, G. Nam,* and K. I. Choi.,* ”Novel 6-N-arylcarboxamidopyrazolo[4,3-d]pyrimidin-7-one derivative as potential anti-cancer agents Bioorg. Med. Chem. Lett. 2010, 17, 4793-4796.

논문(최근 5년)

-  Synthesis and Biological Evaluation of Aryloxazole Derivatives as Antimitotic and Vascular-Disrupting Agents for Cancer Therapy[Journal of medicinal chemistry,2013-11-01] -  Discovery of aryl-biphenyl-2-ylmethylpiperazines as novel scaffolds for 5-HT7 ligands and role of the aromatic substituents in binding to the target receptor[Bioorganic & medicinal chemistry,2013-05-01] -  A novel glucosamine derivative exerts anti-inflammatory actions via inhibition of nuclear factor-kappaB[Neuroscience letters,2013-08-01] -  Synthesis and biological evaluation of 1-(isoxazol-5-ylmethylaminoethyl)-4-phenyl tetrahydropyridine and piperidine derivatives as potent T-type calcium channel blockers with antinociceptive effect in a neuropathic pain model[European journal of medicinal chemistry,2014-03-01] -  Synthesis and antibacterial activities of new piperidine substituted (5R)-[1,2,3]triazolylmethyl and (5R)-[(4-F-[1,2,3]triazolyl)methyl] oxazolidinones[Bioorganic & medicinal chemistry letters,2013-03-01] -  Oxazolopyridines and thiazolopyridines as monoamine oxidase B inhibitors for the treatment of Parkinson’s disease [Bioorganic & medicinal chemistry,2013-09-01] -  Synthesis and the 5-HT6 receptor antagonistic effect of 3-arylsulfonylamino-5,6-dihydro-6-substituted pyrazolo[3,4]pyridinones for neuropathic pain treatment[Bioorganic & medicinal chemistry letters,2013-08-01] -  Pyridyl-urea Derivatives as Blockers of Aβ-induced mPTP Opening for Alzheimer's Disease[Bulletin of the Korean Chemical Society,2012-11-01] -  Aryl Biphenyl-3-ylmethylpiperazines as 5-HT7 Receptor Antagonists[CHEMMEDCHEM,2013-11-01] -  Synthesis and Nrf2 Activating Ability of Thiourea and Vinyl Sulfoxide Derivatives[Bulletin of the Korean Chemical Society,2013-08-01] -  Synthesis and in Vitro Evaluation of the Antitubercular and Antibacterial Activity of Novel Oxazolidinones Bearing Octahydrocyclopenta[c]pyrrol-2-yl Moieties[Chemical & pharmaceutical bulletin,2014-12-01] -  Synthesis and Biological Evaluation of 2-Phenylimino-5((5-phenylfuran-2-yl)methylene)thiazolidin-4-ones as IKK2 inhibitors[Bulletin of the Korean Chemical Society,2015-11-01] -  Isoxazoline, Isoxazole, and Oxadiazole Derivatives as M1 Muscarinic Acetylcholine Receptor Agonists[Bulletin of the Korean Chemical Society,2016-07-01] -  Discovery of a Nanomolar Multikinase Inhibitor (KST016366): A New Benzothiazole derivative with Remarkable Broad Spectrum of Antiproliferative Activity[CHEMMEDCHEM,2016-08-01] -  Monitoring of Intracellular Tau Aggregation Regulated by OGA/OGT Inhibitors[INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2015-08-19] -  Synthesis and T-type calcium Channel-blocking effects of aryl(1,5,-disubstituted-pyzol-3-yl)methyl sulfonamides for neuropathic pain treatment[ EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2016-11-01] -  Synthesis and evaluation of 6-pyrazoylamido-3N-substituted azabicyclo[3,1,0]hexane derivatives as T-type calcium channel inhibitors for treatment of neuropathic pain[BIOORGANIC & MEDICINAL CHEMISTRY,2016-11-11] -  Evaluation of the Chemical Reporter Analog PNP-6AzGlcNAc as an O-GlcNAcase Substrate[ BULLETIN OF THE KOREAN CHEMICAL SOCIETY,2017-02-08] -  Synthesis and diabetic neuropathic pain-alleviating effects of 2N-(pyrazol-3-yl)methylbenzo[d]isothiazole-1,1-dioxide derivatives[Bioorganic & medicinal chemistry,2017-09-01] -  Neuropathic pain-alleviating effects of pyrazole-conjugated arylsulfonamides as 5-HT6 receptor antagonists[Bioorganic & medicinal chemistry letters,2017-09-01]

특허(최근 5년)

-  세로토닌 5-HT3A 길항적 효과를 갖는 퀴나졸린 유도체 함유 약제 조성물[2014-06-10] -  항암활성을 가지는 2,4-다이아미노퀴나졸린 화합물[2013-05-06] -  항암활성을 지닌 카르보아졸계 화합물[2013-08-12] -  1,6-이치환-3-아미노-4,5,6,7-테트라하이드로-1H-피라졸로[3,4-c]피리딘-7-온 유도체 및 그의 제조방법[2013-02-26] -  칼슘이온 채널 조절제로서 유효한 피라졸릴메틸아민-피페라진 유도체와 이의 제조방법[2012-10-30] -  칼슘채널 조절제로서 유효한 이미다졸릴알킬카르보닐 유도체 및 그의 제조방법[2013-07-23] -  칼슘이온 채널 조절제로서 유효한 페닐피라졸릴메틸-2-(4-치환된피페리딘-1-일)아세트아마이드 유도체[2013-07-31] -  메틸리덴-헤테로싸이클릭 화합물[2013-10-08] -  T-형 칼슘 채널 길항제로서의 5-(치환된알킬아미노메틸)아이속사졸계 화[2014-04-21] -  GSK-3 억제활성을 보이는 1H-인다졸 화합물[2013-05-07] -  벤조아릴우레이도 화합물, 및 이를 함유하는 퇴행성 뇌질환 예방 또는 치료용 조성물[2014-11-21] -  세로토닌 5-HT6저해 활성을 갖는 5-설포닐아미노-5,6-다이하이드로-1H-피라졸로[3,4-c]피리딘-7(4H)-온 화합물[2014-11-03] -  칼슘이온 채널 조절제로서 유효한 피라졸-아자바이사이클로[3.1.0]헥산 화합물 및 이의 약학적 조성물[2014-11-25] -  벤조아릴우레이도 화합물, 및 이를 함유하는 퇴행성 뇌질환 예방 또는 치료용 조성물[2015-04-21] -  Nrf2 활성화능을 갖는 신규 화합물, 이를 포함하는 약학적 조성물[2015-05-27] -  칼슘이온 채널 조절제로서 유효한 피라졸-아자바이사이클로[3.1.0]헥산 화합물 및 이의 약학적 조성물[2015-09-22] -  전압계패 칼슘이온채널 억제 활성화능을 갖는 신규 화합물:이를 포함하는 약학적 조성물[2016-11-15] -  전압계패 칼슘이온채널 억제 활성화능을 갖는 신규 화합물:이를 포함하는 약학적 조성물[2016-12-07] -  칼슘이온 채널 조절제로서 유효한 피라졸-아자바이사이클로[3.1.0]헥산 화합물 및 이의 약학적 조성물[2015-09-25] -  신규한 퀴놀린 유도체 및 이를 포함하는 암의 예방 또는 치료용 약학 조성물 [2017-09-11]