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김광명 교수

Kim, Kwangmeyung

INFO

  • 소속캠퍼스한국과학기술연구원 스쿨
  • 전공 바이오-메디컬 융합
    (의공학)
  • 연락처02-958-5916
  • 출신전공생체재료
  • 학위박사
  • 최종출신대학광주과학기술원
  • 이메일

연구분야

나노메디슨

대표연구실적

-   1. Min KH, Lee HJ, Kim K, Kwon IC, Jeong SY, Lee SC, The tumor accumulation and therapeutic efficacy of doxorubicin carried in calcium phosphate-reinforced polymer nanoparticles, Biomaterials, 2012;33;5788-97. -  2. Cho HJ, Yoon HY, Koo H, Shim JS, Park JH, Kim K, Kwon IC, Kim DD, Hyaluronic acid-ceramide-based optical/MR dual imaging nanoprobes for cancer diagnosis, J Control Release, 2012;162;111-8. -  3. Ryu JH, Koo H, Sun IC, Yook SH, Choi K, Kim K, Kwon IC, Tumor-targeting multi-functional nanoparticles for theragnosis: New paradigm for cancer therapy, 2012, Advanced Drug Delivery Reviews, 2012;64;1447-1458.

논문(최근 5년)

-  Tumor-Targeting Transferrin Nanoparticles for Systemic Polymerized siRNA Delivery in Tumor-Bearing Mice[Bioconjugate chemistry,2013-11-01] -  Dextran sulfate-coated superparamagnetic iron oxide nanoparticles as a contrast agent for atherosclerosis imaging[Carbohydrate polymers,2014-01-01] -  TNF-α Gene Silencing Using Polymerized siRNA/Thiolated Glycol Chitosan Nanoparticles for Rheumatoid Arthritis[Molecular therapy,2014-02-01] -  Chemical tumor-targeting of nanoparticles based on metabolic glycoengineering and click chemistry[ACS Nano,2014-03-01] -  Biomimetic Aggrecan Reduces Cartilage Extracellular Matrix From Degradation and Lowers Catabolic Activity in Ex Vivo and In Vivo Models[Macromolecular bioscience,2013-09-01] -  Photo-crosslinked hyaluronic acid nanoparticles with improved stability for in vivo tumor-targeted drug delivery[Biomaterials,2013-07-01] -  Ischemic brain imaging using fluorescent gold nanoprobes sensitive to reactive oxygen species[Journal of controlled release ,2013-09-01] -  Tumor-Homing Glycol Chitosan-Based Optical/PET Dual Imaging Nanoprobe for Cancer Diagnosis[Bioconjugate chemistry,2014-03-01] -  Tailoring Polymersome Bilayer Permeability Improves Enhanced Permeability and Retention Effect for Bioimaging[ACS Applied Materials & Interfaces,2014-07-01] -  Multilayer nanoparticles for sustained delivery of exenatide to treat type 2 diabetes mellitus[Biomaterials,2013-11-01] -  Hyperacute direct thrombus imaging using computed tomography and gold nanoparticles[Annals of neurology,2013-05-01] -  Facile Method To Radiolabel Glycol Chitosan Nanoparticles with 64Cu via Copper-Free Click Chemistry for MicroPET Imaging[Molecular pharmaceutics,2013-04-01] -  Cancer cell-specific photoactivity of pheophorbide a-glycol chitosan nanoparticles for photodynamic therapy in tumor-bearing mice[Biomaterials,2013-09-01] -  Silica coated gold nanorods for imaging and photo-thermal therapy of cancer cells[Journal of nanoscience and nanotechnology,2013-05-01] -  Non-invasive optical imaging of cathepsin B with activatable fluorogenic nanoprobes in various metastatic models[Biomaterials,2014-02-01] -  Bioreducible hyaluronic acid conjugates as siRNA carrier for tumor targeting[Journal of controlled release ,2013-12-01] -  Bioorthogonal copper-free click chemistry in vivo for tumor-targeted delivery of nanoparticles[Angewandte Chemie international edition,2012-11-01] -  Liver-Specific and Echogenic Hyaluronic Acid Nanoparticles Facilitating Liver Cancer Discrimination[Advanced functional materials,2013-11-01] -  Hypoxia-responsive polymeric nanoparticles for tumor-targeted drug delivery[Biomaterials,2014-02-01] -  Magnetic, optical gold nanorods for recyclable photothermal ablation of bacteria[Journal of materials chemistry. B, Materials for biology and medicine,2014-02-01] -  The multilayer nanoparticles formed by layer by layer approach for cancer-targeting therapy[Journal of controlled release ,2013-01-01] -  Robust PEGylated hyaluronic acid nanoparticles as the carrier of doxorubicin: Mineralization and its effect on tumor targetability in vivo[Journal of controlled release ,2013-06-01] -  Biocompatible gelatin nanoparticles for tumor-targeted delivery of polymerized siRNA in tumor-bearing mice[Journal of controlled release ,2013-11-01] -  Systemic Delivery of siRNA by Chimeric Capsid Protein: Tumor Targeting and RNAi Activity in Vivo[Molecular pharmaceutics,2013-01-01] -  DNA amplification in neutral liposomes for safe and efficient gene delivery[ACS Nano,2014-05-01] -  Structural modification of siRNA for efficient gene silencing[Biotechnology advances,2013-09-01] -  Tetraiodothyroacetic acid-tagged liposomes for enhanced delivery of anticancer drug to tumor tissue via integrin receptor[Journal of controlled release ,2012-12-01] -  Engineered protein nanoparticles for in vivo tumor detection[Biomaterials,2014-08-01] -  In vivo fluorescence imaging for cancer diagnosis using receptor-targeted epidermal growth factor-based nanoprobe[Biomaterials,2013-12-01] -  Functional transformations of bile acid transporters induced by high-affinity macromolecules[Scientific Reports,2014-02-01] -  Hyaluronic acid derivative-coated nanohybrid liposomes for cancer imaging and drug delivery[Journal of controlled release ,2014-01-01] -  Nano-enabled delivery systems across the blood-brain barrier[Archives of pharmacal research ,2014-01-01] -  Cell Labeling and Tracking Method without Distorted Signals by Phagocytosis of Macrophages[Theranostics ,2014-04-01] -  Accurate sequential detection of primary tumor and metastatic lymphatics using a temperature-induced phase transition nanoparticulate system[International journal of nanomedicine,2014-06-01] -  Self-crosslinked human serum albumin nanocarriers for systemic delivery of polymerized siRNA to tumors[Biomaterials,2013-12-01] -  Characterization of Partial Ligation-Induced Carotid Atherosclerosis Model Using Dual-Modality Molecular Imaging in ApoE Knock-out Mice[PLoS ONE ,2013-09-01] -  Hyaluronic Acid-Gold Nanoparticle/Interferon α Complex for Targeted Treatment of Hepatitis C Virus Infection[ACS Nano,2012-11-01] -  Detection of Active Matrix Metalloproteinase-3 in Serum and Fibroblast-Like Synoviocytes of Collagen-Induced Arthritis Mice[Bioconjugate chemistry,2013-05-01] -  Effect of HIFU treatment on tumor targeting efficacy of docetaxel-loaded Pluronic nanoparticles[Colloids and surfaces. B, Biointerfaces,2014-07-01] -  Oligomeric bile acid-mediated oral delivery of low molecular weight heparin[Journal of controlled release ,2014-02-01] -  Enhanced drug-loading and therapeutic efficacy of hydrotropic oligomer-conjugated glycol chitosan nanoparticles for tumor-targeted paclitaxel delivery[Journal of controlled release ,2013-12-01] -  Non-invasive optical imaging of matrix metalloproteinase activity with albumin-based fluorogenic nanoprobes during angiogenesis in a mouse hindlimb ischemia model[Biomaterials,2013-09-01] -  Blood-pool multifunctional nanoparticles formed by temperature-induced phase transition for cancer-targeting therapy and molecular imaging[International journal of pharmaceutics,2012-11-01] -  A polymeric conjugate foreignizing tumor cells for targeted immunotherapy in vivo[Journal of controlled release ,2015-02-01] -  Advances in targeting strategies for nanoparticles in cancer imaging and therapy[Nanoscale,2014-11-01] -  Amphiphilized poly(ethyleneimine) nanoparticles: a versatile multi-cargo carrier with enhanced tumor-homing efficiency and biocompatibility[Journal of materials chemistry. B, Materials for biology and medicine,2015-01-01] -  Bioreducible carboxymethyl dextran nanoparticles for tumor-targeted drug delivery[Advanced Healthcare Materials,2014-11-01] -  Cancer-targeted MDR-1 siRNA delivery using self-cross-linked glycol chitosan nanoparticles to overcome drug resistance[Journal of controlled release ,2015-01-01] -  Design of a multicomponent peptide-woven nanocomplex for delivery of siRNA[PLoS ONE ,2015-02-01] -  Fluorescent Dye Labeled Iron Oxide/Silica Core/Shell Nanoparticle as a Multimodal Imaging Probe[Pharmaceutical research,2014-12-01] -  Glycol chitosan nanoparticles as specialized cancer therapeutic vehicles: Sequential delivery of doxorubicin and Bcl-2 siRNA[Scientific Reports,2014-11-01] -  Induced phenotype targeted therapy: radiation-induced apoptosis-targeted chemotherapy[Journal of the National Cancer Institute: JNCI,2015-02-01] -  Inhibition of Notch signalling ameliorates experimental inflammatory arthritis[Annals of the rheumatic diseases: the official journal,2015-01-01] -  Prevention effect of orally active heparin conjugate on cancer-associated thrombosis[Journal of controlled release ,2014-12-01] -  Proteinticle/Gold Core/Shell Nanoparticles for Targeted Cancer Therapy without Nanotoxicity[Advanced materials,2014-10-01] -  The potential and advances in RNAi therapy: Chemical and structural modifications of siRNA molecules and use of biocompatible nanocarriers[Journal of controlled release ,2014-11-01] -  pH-Controlled Gas-Generating Mineralized Nanoparticles: A Theranostic Agent for Ultrasound Imaging and Therapy of Cancers[ACS Nano,2015-01-01] -  Hyaluronic acid nanoparticles for active targeting atherosclerosis[Biomaterials,2015-06-01] -  Molecular imaging and targeted drug delivery using albumin-based nanoparticles[Current pharmaceutical design,2015-04-01] -  Multifunctional nanoparticles for gene delivery and spinal cord injury[Journal of biomedical materials research. Part A,2015-11-01] -  In vivo stem cell tracking with imageable nanoparticles that bind bioorthogonal chemical receptors on the stem cell surface[Biomaterials,2017-09-01]

특허(최근 5년)

-  PCR 기반의 유전자 전달체 및 그 제조방법[2014-08-29] -  생물 직교성 무동 클릭 화학을 통한 나노입자의 생체내 표적화 방법[2014-07-01] -  종양 표적화 가스 발생 나노입자, 그 제조방법 및 이를 이용한 종양 표적화 약물 전달 나노입자[2014-05-23] -  혈액 처리용 조성물 및 이를 포함하는 자가면역질환 진단용 키트 세트[2013-10-14] -  의수 제어를 위한 말초신경 인터페이스 시스템 및 방법[2014-03-03] -  의수 제어를 위한 말초신경 인터페이스 시스템 및 방법[2014-03-18] -  리피오돌을 함유하는 컴퓨터 단층촬영용 혈관 조영제[2013-05-07] -  손상된 신경의 기능을 복구하기 위한 인공신경 네트워킹 시스템 및 방법[2013-03-05] -  손상된 신경의 기능을 복구하기 위한 인공신경 네트워킹 시스템 및 방법[2014-03-04] -  사람 혈청 알부민-siRNA 나노입자 전달체[2013-08-20] -  종양으로의 축적성을 향상시킨 약물전달용 생체적합성 고분자 전달체의 제조방법 및 그 나노 전달체[2013-09-06] -  수계 분산 근적외 광열 유기 나노 입자 및 이의 제조 방법과 용도[2012-12-12] -  사람 혈청 알부민-siRNA 나노입자 전달체[2013-01-11] -  전하결합 및 생분해성 공유결합으로 동시에 연결된 고분자-siRNA 나노입자 전달체[2013-01-11] -  폴리-시스테인 펩티드 융합 재조합 알부민 및 이의 제조방법[2013-07-10] -  폴리-시스테인 펩티드 융합 재조합 알부민 및 이의 제조방법[2013-09-24] -  작은 올리고뉴클레오티드의 중합 방법 및 상기 중합 방법에 의하여 제조된 고분자 올리고뉴클레오티드의 용도[2013-09-10] -  발광 고분자로 구성된 나노입자 및 그 제조 방법[2013-02-05] -  헤파라나제 활성 측정용 이온 복합체 나노 입자 및 그 제조 방법[2013-08-07] -  헤파라나제 활성 측정용 이온 복합체 나노 입자 및 그 제조 방법[2013-08-07] -  헤파라나제 활성 측정용 이온 복합체 나노 입자 및 그 제조 방법[2013-08-07] -  헤파라나제 활성 측정용 이온 복합체 나노 입자 및 그 제조 방법[2012-12-04] -  고분자 유도체-광감작제 복합체를 이용한 새로운 광역학 치료제[2013-12-24] -  단백질 분해효소 검출 및 생체 내 영상화를 위한 금속 나노입자 및 그것의 용도[2013-10-08] -  단백질 분해 효소 활성 측정용 인 비트로 키트 및 그 제조방법 [2014-10-14] -  표피생장인자 수용체 (EGFR)-양성 종양 표적화 소광 나노프로브 및 이의 제조방법[2014-11-26] -  피브린 표적 펩타이드 서열이 결합된 글라이콜 키토산-금 나노입자를 포함하는 혈전 탐지용 CT 조영제[2014-12-11] -  롤링 서클 트랜스크립션에 의한 siRNA 다량체의 제조방법 및 상기 방법에 의하여 제조된 siRNA 다량체[2015-06-25] -  나노프로브를 이용한 자가면역질환 진단용 말초 혈액 세포 내 활성 기질 금속 단백질 분해효소의 정량화 방법[2015-03-11] -  siRNA의 종양 표적화된 전달을 위한 젤라틴 기반 나노입자 복합체 및 그 제조방법[2016-05-17] -  티올화 글리콜 키토산-거대분자 전송 도메인 복합체를 포함하는 안구질환 치료용 약물전달 시스템 및 그 제조방법[2015-12-02] -  간 종양 표적화 초음파 조영제 및 그 제조방법[2016-02-16] -  종양 표적화 가스 발생 나노입자, 그 제조방법 및 이를 이용한 종양 표적화 약물 전달 나노입자[2016-02-16] -  방사선 또는 자외선 조사에 의해 활성화되는 항암제 전구체 및 이의 용도[2016-08-09] -  siRNA의 종양 표적화된 전달을 위한 젤라틴 기반 나노입자 복합체 및 그 제조방법[2016-08-16] -  종양의 특이적 검출을 위한 약물-형광체 복합체[2016-08-09]