본문 바로가기 대메뉴 바로가기
임혜원 교수

Rhim, Hyewhon

INFO

  • 소속캠퍼스한국과학기술연구원 스쿨
  • 전공 바이오-메디컬 융합
    (생체신경과학)
  • 연락처02-958-7011
  • 출신전공신경생리학
  • 학위박사
  • 최종출신대학University of Chicago
  • 이메일

연구분야

신경생물학 ; 생리약학 ; 의과학

Neurobiology ; Physiological Pharmacy ; Medical Sciences

대표연구실적

-  Lee, M. S., Kim, Y. H., Park, W. S., Park, O. K., Kwon, S., Hong, K., H. Rhim, I. Shim, K. Morita, D. L .Wong, P. D. Patel, D. M. Lyons, A. F. Schatzberg & Her. S./ Temporal variability of glucocorticoid receptor activity is functionally important for the therapeutic action of fluoxetine in the hippocampus./ Molecular psychiatry/2014.09 -  Kim J, Kim Y, Tae J, Yeom M, Moon B, Huang XP, Roth BL, Lee K, Rhim H, Choo IH, Chong Y, Keum G, Nam G, Choo H/ Aryl Biphenyl-3-ylmethylpiperazines as 5-HT7 Receptor Antagonists./ ChemMedChem./2013. 11 -  Kim, S. H., Kim, D. H., Lee, K. H., Im, S. K., Hur, E. M., Chung, K. C., & Rhim, H./ Direct Interaction and functional coupling between human 5-HT6 receptor and the light chain 1 subunit of the microtubule-associated protein 1B (MAP1B-LC1)./ PloS one /2014. 02

논문(최근 5년)

-  Novel N-biphenyl-2-ylmethyl 2-methoxyphenylpiperazinylalkanamides as 5-HT7R antagonists for the treatment of depression[Bioorganic & medicinal chemistry,2014-09-01] -  Direct Interaction and Functional Coupling between Human 5-HT6 Receptor and the Light Chain 1 Subunit of the Microtubule-Associated Protein 1B (MAP1B-LC1)[PLoS ONE ,2014-03-01] -  Synthesis and biological evaluation of isoxazoline derivatives as potent M1 muscarinic acetylcholine receptor agonists[Bioorganic & medicinal chemistry letters,2015-04-01] -  Temporal variability of glucocorticoid receptor activity is functionally important for the therapeutic action of fluoxetine in the hippocampus[Molecular psychiatry,2016-02-01] -  Novel N-acyl-carbazole derivatives as 5-HT7R antagonists[European journal of medicinal chemistry,2016-03-01] -  Isoxazoline, Isoxazole, and Oxadiazole Derivatives as M1 Muscarinic Acetylcholine Receptor Agonists[Bulletin of the Korean Chemical Society,2016-07-01] -  Gintonin absorption in intestinal model systems[Journal of Ginseng Research,2018-01-01]

특허(최근 5년)

-  T-형 칼슘 채널 길항제로서의 5-(치환된알킬아미노메틸)아이속사졸계 화[2014-04-21] -  세로토닌 5-HT3A 길항적 효과를 갖는 퀴나졸린 유도체 함유 약제 조성물[2014-06-10] -  벤조아릴우레이도 화합물, 및 이를 함유하는 퇴행성 뇌질환 예방 또는 치료용 조성물[2014-11-21] -  세로토닌 5-HT6저해 활성을 갖는 5-설포닐아미노-5,6-다이하이드로-1H-피라졸로[3,4-c]피리딘-7(4H)-온 화합물[2014-11-03] -  벤조아릴우레이도 화합물, 및 이를 함유하는 퇴행성 뇌질환 예방 또는 치료용 조성물[2015-04-21] -  하나의 탐침을 사용하여 전기생리적으로 확인된 뇌 부위에 정확히 약물을 주입하는 방법[2018-01-19]