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금교창 교수

Keum Gyo Chang

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  • 소속캠퍼스한국과학기술연구원 스쿨
  • 전공 바이오-메디컬 융합
    (생물화학)
  • 연락처02-958-5148
  • 출신전공유기화학
  • 학위박사
  • 최종출신대학서울대학교
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연구분야

유기화학, 의약화학

Organic Synthesis; Medicinal Chemistry

대표연구실적

-  Keum, Gyochang; Hwang, Cheol Hee; Kang, Soon Bang; Kim, Youseung; Lee, Eun, Stereoselective Syntheses of Rolliniastatin 1, Rollimembrin, and Membranacin, J. Amer. Chem. Soc, July 1, 2005) -  Cole GB, Keum G, Liu J, Small GW, Satyamurthy N, Kepe V, Barrio JR, Specific estrogen sulfotransferase (SULT1E1) substrates and molecular imaging probe candidates, Proc Natl Acad Sci USA, (April 6, 2010) -  Ashraf Kareem El-Damasy, Ju-Hyeon Lee, Seon Hee Seo, Nam-Chul Cho, Ae Nim Pae, Gyochang Keum, Design and synthesis of new potent anticancer benzothiazole amides and ureas featuring pyridylamide moiety and possessing dual B-RafV600E and C-Raf kinase inhibitory activities, Eur. J. Med. Chem. (June 10, 2016)

논문(최근 5년)

-  Novel N-biphenyl-2-ylmethyl 2-methoxyphenylpiperazinylalkanamides as 5-HT7R antagonists for the treatment of depression[Bioorganic & medicinal chemistry,2014-09-01] -  Determination of Edible Vegetable Oil Adulterants in Sesame Oil Using 1H Nuclear Magnetic Resonance Spectroscopy[Analytical letters,2014-07-01] -  Synthesis and biological evaluation of 1-(isoxazol-5-ylmethylaminoethyl)-4-phenyl tetrahydropyridine and piperidine derivatives as potent T-type calcium channel blockers with antinociceptive effect in a neuropathic pain model[European journal of medicinal chemistry,2014-03-01] -  Efficient synthesis of mibefradil analogues: an insight into in vitro stability[ORGANIC & BIOMOLECULAR CHEMISTRY,2014-08-14] -  Synthesis and in vivo evaluation of 5-methoxy-2-(phenylethynyl)quinoline (MPEQ) and [11C]MPEQ targeting metabotropic glutamate receptor 5 (mGluR5)[Bulletin of the Korean Chemical Society,2014-08-20] -  Therapeutic Targeting of Epigenetic Components in Amyotrophic Lateral Sclerosis (ALS)[Current Medicinal Chemistry,2014-09-25] -  Chemo- and Stereoselective Reduction of β-Keto-α-oximino Nitriles by Using Baker's Yeast[European journal of organic chemistry,2015-02-01] -  Facile diverted synthesis of pyrrolidinyl triazoles using organotrifluoroborate: discovery of potential mPTP blockers[Organic & biomolecular chemistry,2014-12-01] -  Novel thienopyrimidinones as mGluR1 antagonists[European journal of medicinal chemistry,2014-10-01] -  Synthesis and in Vitro Evaluation of the Antitubercular and Antibacterial Activity of Novel Oxazolidinones Bearing Octahydrocyclopenta[c]pyrrol-2-yl Moieties[Chemical & pharmaceutical bulletin,2014-12-01] -  Synthesis and biological evaluation of isoxazoline derivatives as potent M1 muscarinic acetylcholine receptor agonists[Bioorganic & medicinal chemistry letters,2015-04-01] -  ABL kinase inhibitory and antiproliferative activity of novel picolinamide based benzothiazoles[Bioorganic & medicinal chemistry letters,2015-05-15] -  Discovery and biological evaluation of tetrahydrothieno[2,?3-?c]?pyridine derivatives as selective metabotropic glutamate receptor 1 antagonists for the potential treatment of neuropathic pain[European journal of medicinal chemistry,2015-06-05] -  Synthesis and biological evaluation of aryl isoxazole derivatives as metabotropic glutamate receptor 1 antagonists: A potential treatment for neuropathic pain[Bioorganic & medicinal chemistry letters,2015-03-15] -  Design, synthesis, in-vitro antiproliferative activity and kinase profile of new picolinamide based 2-amido and ureido quinoline derivatives[European journal of medicinal chemistry,2015-08-28] -  Novel benzidine and diaminofluorene prolinamide derivatives as potent hepatitis C virus NS5A inhibitors[European journal of medicinal chemistry,2015-08-28] -  Synthesis and Biological Evaluation of N3-Alkyl-Thienopyrimidin-4-Ones as mGluR1 Antagonists[Bulletin of the Korean Chemical Society,2015-05-01] -  Tubulin Inhibitor Identification by Bioactive Conformation Alignment Pharmacophore (BCAP)-Guided Virtual Screening[ CHEMICAL BIOLOGY & DRUG DESIGN,2015-11-01] -  Virtual Screening and Synthesis of Novel Antitubercular Agents through Interaction-based Pharmacophore and Molecular Docking Studies[CURRENT COMPUTER-AIDED DRUG DESIGN,2015-12-01] -  Design and synthesis of new potent anticancer benzothiazole amides and ureas featuring pyridylamide moiety and possessing dual B-RafV600E and C-Raf kinase inhibitory activities[ EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2016-06-10] -  Synthesis of pyrazine via chemoselective reduction of β-keto-α-oximino ester using baker’s yeast[Journal of molecular catalysis. B, Enzymatic,2016-01-01] -  Isoxazoline, Isoxazole, and Oxadiazole Derivatives as M1 Muscarinic Acetylcholine Receptor Agonists[Bulletin of the Korean Chemical Society,2016-07-01] -  Discovery of a Nanomolar Multikinase Inhibitor (KST016366): A New Benzothiazole derivative with Remarkable Broad Spectrum of Antiproliferative Activity[CHEMMEDCHEM,2016-08-05] -  Novel 5-substituted-2-anilinoquinolines with 3-(morpholino or 4-methylpiperazin-1-yl)propoxy moiety as broad spectrum antiproliferative agents: Synthesis, cell based assays and kinase screening[Bioorganic & medicinal chemistry letters,2016-07-15] -  Coordinative Amphiphiles as Tunable siRNA Transporters[ BIOCONJUGATE CHEMISTRY,2016-08-17] -  Synthesis and T-type calcium channel-blocking effects of aryl(1,5-disubstituted-pyrazol-3-yl)methyl sulfonamides for neuropathic pain treatment[EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2016-11-10] -  New potent biaryl sulfate-based hepatitis C virus inhibitors[ EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2017-01-05] -  ‘Design and synthesis of new 2-anilinoquinolines bearing N-methylpicolinamide moiety as potential antiproliferative agents[ CHEMICAL BIOLOGY & DRUG DESIGN,2017-01-01] -  Synthesis and in vitro antiproliferative activity of C5-benzyl substituted 2-amino-pyrrolo[2,3-d]pyrimidines as potent Hsp90 inhibitors[ BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2017-01-15] -  Synthesis and diabetic neuropathic pain-alleviating effects of 2N-(pyrazol-3-yl)methylbenzo[d]isothiazole-1,1-dioxide derivatives[Bioorganic & medicinal chemistry,2017-09-01]

특허(최근 5년)

-  T-형 칼슘 채널 길항제로서의 5-(치환된알킬아미노메틸)아이속사졸계 화[2014-04-21] -  벤조아릴우레이도 화합물, 및 이를 함유하는 퇴행성 뇌질환 예방 또는 치료용 조성물[2014-11-21] -  세로토닌 5-HT6저해 활성을 갖는 5-설포닐아미노-5,6-다이하이드로-1H-피라졸로[3,4-c]피리딘-7(4H)-온 화합물[2014-11-03] -  칼슘이온 채널 조절제로서 유효한 피라졸-아자바이사이클로[3.1.0]헥산 화합물 및 이의 약학적 조성물[2014-11-25] -  칼슘이온 채널 조절제로서 유효한 피라졸-아자바이사이클로[3.1.0]헥산 화합물 및 이의 약학적 조성물[2015-09-22] -  벤조아릴우레이도 화합물, 및 이를 함유하는 퇴행성 뇌질환 예방 또는 치료용 조성물[2015-04-21] -  옥사졸리디논 화합물 및 이를 포함하는 C형 간염 예방 또는 치료용 약학 조성물[2015-10-14] -  2,4,6-삼치환된 테트라하이드로파이란 유도체의 입체 선택적 제조방법[2014-03-19] -  2,4,6-삼치환된 테트라하이드로파이란 유도체의 입체 선택적 제조방법[2015-11-02] -  5-HT7 수용체에 작용하는 카바졸 유도체[2016-10-31] -  mGluR5의 표식용 방사성 조성물[2014-07-03] -  HSP90 억제능을 갖는 신규한 퓨린 유도체 및 이를 포함하는 항암제 약학 조성물[2017-01-03] -  옥사졸리디논 화합물 및 이를 포함하는 C형 간염 예방 또는 치료용 약학 조성물[2014-11-12] -  피롤로 피리미딘 유도체를 포함하는 HSP90 억제제 및 이를 포함하는 항암제 약학 조성물 [2014-11-18] -  5-HT7 수용체에 작용하는 카바졸 유도체[2015-02-24] -  4-(2-벤질옥시페닐)-1-(피롤리딘-3-일)-1,2,3-트리아졸 화합물[2015-02-24] -  MAO-B 저해제로 작용하는 벤조옥사졸과 벤조사이아졸 유도체[2015-05-22] -  대사성 글루타메이트 수용체 1에 활성을 지닌 신규 아릴 이소옥사졸 유도체[2015-06-17] -  대사성 글루타메이트 수용체 1, 5에 활성을 보이는 신규 테트라하이드로티에노[2,3-c]피리딘 유도체[2016-06-20] -  신규한 유레이도벤조싸이아졸 유도체 및 이를 포함하는 암의 예방 또는 치료용 약학 조성물[2015-08-21] -  mGluR5의 표식용 방사성 조성물[2015-12-16] -  2,4,6-삼치환된 테트라하이드로파이란 유도체의 입체 선택적 제조방법[2015-11-02] -  옥사졸리디논 화합물 및 이를 포함하는 C형 간염 예방 또는 치료용 약학 조성물[2016-08-23] -  대사성 글루타메이트 수용체 1, 5에 활성을 보이는 신규 테트라하이드로티에노[2,3-c]피리딘 유도체[2016-06-20] -  mGluR5 길항제로서의 티아졸-2-카르복사아마이드 유도체 및 이의 제조방법[2016-11-02] -   신규한 2-아미노 퓨린 유도체 및 이를 포함하는 암의 예방 또는 치료용 약학 조성물 [2016-10-11] -  항바이러스 활성을 가지는 카르바졸 화합물[2016-08-30] -  신규한 퀴놀린 유도체 및 이를 포함하는 암의 예방 또는 치료용 약학 조성물 [2016-06-16] -  Zn(II)-Dipicolylamine complex (Zn-DPA)를 포함하는 저분자 siRNA 수송체[2016-08-09] -  MAO-B 저해제로 작용하는 벤조옥사졸과 벤조사이아졸 유도체[2016-05-20] -  신규한 퀴놀린 유도체 및 이를 포함하는 암의 예방 또는 치료용 약학 조성물 [2017-09-11] -  Zn(II)-Dipicolylamine complex (Zn-DPA)를 포함하는 저분자 siRNA 수송체[2018-01-26]