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임혜인 교수

Heh-In Im

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  • 소속캠퍼스한국과학기술연구원 스쿨
  • 전공 바이오-메디컬 융합
    (생체신경과학)
  • 연락처02-958-6961
  • 출신전공신경약리학
  • 학위박사
  • 최종출신대학서울대학교
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연구분야

약물 중독및 파생질환에서 microRNA의 기능과 역할연구

Role of microRNAs in drug addiction and related disorders such as depression and schizophrenia

대표연구실적

-  Hollander JA, Im HI, Amelio AL, Kocerha J, Bali P, Lu Q, Willoughby D, Wahlestedt C, Conkright MD, Kenny PJ., Striatal microRNA controls cocaine intake through CREB signalling. Nature. 2010 Jul 8;466(7303):197-202. -  Im HI, Hollander JA, Bali P, Kenny PJ., MeCP2 controls BDNF expression and cocaine intake through homeostatic interactions with microRNA-212. Nat Neurosci. 2010 Sep;13(9):1120-7. -  Schaefer A, Im HI, Venø MT, Fowler CD, Min A, Intrator A, Kjems J, Kenny PJ, O'Carroll D, Greengard P., Argonaute 2 in dopamine 2 receptor-expressing neurons regulates cocaine addiction. J Exp Med. 2010 Aug 30;207(9):1843-51.

논문(최근 5년)

-  Glial activation with concurrent up-regulation of inflammatory mediators in trimethyltin-induced neurotoxicity in mice.[Acta Histochem.,2014-09-26] -  Integrated miRNA-mRNA analysis in the habenula nuclei of mice intravenously self-administering nicotine[Scientific Reports,2015-08-01] -  Developmental and degenerative modulation of GABAergic transmission in the mouse hippocampus[International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience,2015-10-01] -  Multiplexed Detection of Epigenetic Markers Using Quantum Dot (QD)-Encoded Hydrogel Microparticles[Analytical chemistry ,2016-04-01] -  Pathophysiological role of neuroinflammation in psychiatric disorders[International neurourology journal.,2016-05-01] -  Brain Reward Circuits in Morphine Addiction[Molecules and cells,2016-09-01] -  Intravenous morphine self-administration alters accumbal microRNA profiles in the mouse brain[NEURAL REGENERATION RESEARCH,2017-09-01] -  MicroRNA profiling in aging brain of PSEN1/PSEN2 double knockout mice[Molecular neurobiology,2017-10-01] -  Regulator of G-Protein Signaling 4 (RGS4) Controls Morphine Reward by Glutamate Receptor Activation in the Nucleus Accumbens of Mouse Brain.[MOLECULES AND CELLS,2018-02-27] -  Multiplexed on-chip real-time PCR using hydrogel spot array formicroRNA profiling of minimal tissue samples[SENSORS AND ACTUATORS B-CHEMICAL,2018-02-16] -  Drug abuse and psychosis: New insights into drug-induced psychosis[EXPERIMENTAL NEUROBIOLOGY,2017-02-28] -  Big Data Analysis of Genes Associated with Neuropsychiatric Disorders in an Alzheimer's Disease Animal Model[FRONTIERS IN NEUROSCIENCE,2018-06-01] -  The Role of Dorsal Striatum in Choice Impulsivity[ANNALS OF THE NEW YORK ACADEMY OF SCIENCES,2018-08-06]

특허(최근 5년)

-  마약 중독 여부 진단용 바이오마커 및 마약 중독 여부 진단용 키트[2017-03-31] -  마약 중독 예방 및 치료용 약제학적 조성물[2016-02-22] -  뇌신경계의 표적 부위의 판별 및 약물 주입을 하나의 탐침을 사용하여 동시에 수행하기 위한 약물 주입장치 및 이를 이용한 약물 주입 방법[2018-01-19]

연구과제 수행 실적

메스암페타민 노출/중독에 대한 혈액 엑소좀 마이크로RNA 표지자 연구 메스암페타민 금단에 의한 선조체-혈액 마이크로RNA 역변화 연구 팬오믹스 기반 치매 단백질 타깃 발굴 및 검증