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박기덕 교수

Ki Duk Park


  • 소속캠퍼스한국과학기술연구원 스쿨
  • 전공 바이오-메디컬 융합
  • 연락처02-958-5132
  • 출신전공생명공학과
  • 학위박사
  • 최종출신대학연세대학교
  • 이메일


뇌질환 치료제 개발 및 작용기작에 관한 연구

Drug discovery for neurological diseases and identification of drug mechanisms


-  Park K. D., Kim D. U., Reamtong O., Eyers C., Gaskell S. J., Liu. R., Kohn H./Identification of a lacosamide binding protein using an affinity bait and chemical reporter strategy: 14-3-3 ζ/Journal of the American Chemical Society/2011-07-27 -  Woo S. Y, Kim J. H., Moon M. K., Han S.-H., Yeon S. K., Choi J. W., Jang B. K., Song H. J., Kang Y. G., Kim J. W., Lee J., Kim D. J., Hwang O. Y.,* Park K. D.* Discovery of vinyl sulfones as a novel class of neuroprotective agents toward Parkinson’s disease therapy/Journal of Medicinal Chemistry/2014-2-27 -  Lee J. A., Kim J. H., Woo S. Y., Son H. J., Han S. H., Jang B. K., Choi J. W., Kim D. J., Park K. D.* Hwang O.*/ A novel compound VSC2 has anti-inflammatory and antioxidant properties in microglia/ British Journal of Pharmacology/ 2015-02-0130

논문(최근 5년)

-  Differencial regulation of collapsing response mediator protein 2 (CRMP2) phosphorylation by GSK3β and CDK5 following traumatic brain injury[Frontiers in Cellular Neuroscience,2014-05-28] -  Substituted N-(Biphenyl-4’-yl)methyl (R)-2-Acetamido-3-methoxypropionamides: Potent Anticonvulsants That Affect Frequency (Use)-Dependence and Slow Inactivation of Sodium Channels[Journal of Medicinal Chemistry,2014-07-24] -  9-O-butyl-13-(4-isopropylbenzyl)berberine, KR-72, Is a Potent Antifungal Agent That Inhibits the Growth of Cryptococcus neoformans by Regulating Gene Expression[PLoS ONE ,2014-10-01] -  A novel compound VSC2 has anti-inflammatory and antioxidant properties in microglia and in Parkinson's disease animal model.[British journal of pharmacology,2015-02-01] -  Chimeric Agents Derived from the Functionalized Amino Acid, Lacosamide, and the α-Aminoamide, Safinamide: Evaluation of Their Inhibitory Actions on Voltage-Gated Sodium Channels, and Antiseizure and Antinociception Activities and Comparison with Lacosamide and Safinamide[ACS Chemical Neuroscience,2015-02-01] -  Synthesis of a series of unsaturated ketone derivatives as selective and reversible monoamine oxidase inhibitors[Bioorganic & medicinal chemistry,2015-10-01] -  Antioxidant and Anti-Inflammatory Activities of a Natural Compound, Shizukahenriol, through Nrf2 Activation[Molecules,2015-09-01] -  (S)-Lacosamide Binding to Collapsin Response Mediator Protein 2 (CRMP2) Regulates CaV2.2 Activity by Subverting Its Phosphorylation by Cdk5[Molecular neurobiology,2016-03-01] -  Synthesis of Novel Dihydropyridothienopyrimidin-4,9-dione Derivatives[Molecules,2015-03-01] -  Relationship between chromatographic resolution and amide structure of chiral 2-hydroxy acids as O-(?)-menthoxycarbonylated diastereomeric derivatives for enantiomeric separation on achiral gas chromatography[Journal of chromatography. B, Analytical technologies in the biomedical and life sciences,2016-02-01] -  Screening, Synthesis, and In Vitro Evaluation of Vinyl Sulfones as Inhibitors of Complement-Dependent Cytotoxicity in Neuromyelitis Optica[CHEMMEDCHEM,2016-02-01] -  A Novel Compound ITC-3 Activates the Nrf2 Signaling and Provides Neuroprotection in Parkinson’s Disease Models[NEUROTOXICITY RESEARCH,2015-11-01] -  Glycyrrhizic acid prevents astrocyte death by neuromyelitis optica-specific IgG via inhibition of C1q binding[Biochemical and biophysical research communications,2016-09-01] -  (S)-lacosamide inhibition of CRMP2 phosphorylation reduces postoperative and neuropathic pain behaviors through distinct classes of sensory neurons identified by constellation pharmacology[Pain,2016-07-01] -  Efficacy of (S)-lacosamide in preclinical models of cephalic pain[pain reports,2016-08-01] -  Discovery of benzimidazole derivatives as odulators of mitochondrial function: A potential treatment for Alzheimer's disease[ EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2017-01-16] -  Hydroxycholesterol levels in the serum and cerebrospinal fluid of patients with neuromyelitis optica revealed by LC-Ag+CIS/MS/MS and LC-ESI/MS/MS with picolinic derivatization: Increased levels and association with disablility during acute attack[PLOS ONE,2016-12-12] -  α-Pinene, a Major Constituent of Pine Tree Oils, Enhances Non-Rapid Eye Movement Sleep in Mice through GABAA-benzodiazepine Receptors[ MOLECULAR PHARMACOLOGY,2016-10-17] -  Discovery of 2-aryloxy-4-amino-quinazoline derivatives as novel protease-activated receptor 2 (PAR2) antagonists[ BIOORGANIC & MEDICINAL CHEMISTRY,2015-12-01] -  Synthesis and biological evaluation of picolinamides and thiazole-2-carboxamides as mGluR5 (metabotropic glutamate receptor 5) antagonists[ BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2016-01-18] -  Novel scaffold identification of mGlu1 receptor negative allosteric modulators using a hierarchical virtual screening approach[ CHEMICAL BIOLOGY & DRUG DESIGN,2016-02-15] -  Identification of the first in silico-designed TREK1 antagonists that block channel currents dose dependently[ CHEMICAL BIOLOGY & DRUG DESIGN,2016-06-01] -  A novel synthetic isothiocyanate ITC-57 displays antioxidant, anti-inflammatory, and neuroprotective properties in a mouse Parkinson’s disease model[NEUROTOXICITY RESEARCH,2016-11-01] -  Synthesis and evaluation of biaryl derivatives for structural characterization of selective monoamine oxidase B Inhibitors toward Parkinson’s disease therapy[Bioorganic & medicinal chemistry,2018-01-01] -  Activation of the Nrf2 signaling pathway and neuroprotection of nigral dopaminergic neurons by a novel synthetic compound KMS99220[Neurochemistry international,2018-01-01] -  CRISPR/Cas9 editing of Nf1 gene identifies CRMP2 as a therapeutic target in neurofibromatosis type 1 (NF1)-related pain that is reversed by (S)-Lacosamide[Pain,2017-12-01] -  Discovery of thienopyrrolotriazine derivatives to protect mitochondrial function against Aβ-induced neurotoxicity[European journal of medicinal chemistry,2017-12-01]

특허(최근 5년)

-  산화질소 생성 억제 효과와 Nrf2 활성 효과를 통해 신경세포 사멸을 억제함으로써 뇌신경 질환 예방 및 치료용으로 사용 가능한 활성화된 비닐기를 포함하는 벤질 유도체 화합물 및 이의 약학조성물[2014-09-01] -  산화질소 생성 억제용 피라졸로피리미딘 유도체 화합물[2014-03-25] -  Novel N-benzylamide substituted derivatives of 2-(acylamido)acetic acid and 2-(acylamido)propionic acids: potent neurological agents[2014-10-17] -  N-Benzylamide substituted derivatives of 2-(acylamido)acetic acid and 2-(acylamido)propionic acids: potent neurological agents[2015-01-15] -  Nrf2 활성화능을 갖는 신규 화합물, 이를 포함하는 약학적 조성물[2015-05-27] -  세포내 타우 단백질의 상호작용을 모니터링하기 위한 이분자 형광 상보성 아미노산 서열 쌍[2015-08-17] -  mGluR5의 표식용 방사성 조성물[2015-12-16] -  2,4,6-삼치환된 테트라하이드로파이란 유도체의 입체 선택적 제조방법[2015-11-02] -  대사성 글루타메이트 수용체 1, 5에 활성을 보이는 신규 테트라하이드로티에노[2,3-c]피리딘 유도체[2016-06-20] -  대사성 글루타메이트 수용체 1에 활성을 지닌 신규 아릴 이소옥사졸 유도체[2016-09-30] -  4-(2-벤질옥시페닐)-1-(피롤리딘-3-일)-1,2,3-트리아졸 화합물[2016-10-05] -  T-형 칼슘 채널 길항제로서의 크로메인 유도체[2016-11-18] -  알파-아미노아미드 유도체 화합물 및 이를 포함하는 약학적 조성물[2016-11-21] -  5-HT7 수용체에 작용하는 이중으로 치환된 바이페닐 유도체, 이의 제조방법 및 이를 유효성분으로 포함하는 약학조성물[2017-11-02]