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김소연 교수

So Yeon Kim

INFO

  • 소속캠퍼스한국과학기술연구원 스쿨
  • 전공 바이오-메디컬 융합
    (의공학)
  • 연락처02-958-5914
  • 출신전공생물리화학
  • 학위박사
  • 최종출신대학Stanford University
  • 이메일

연구분야

세포미세 환경을 이용한 세포 운명 및 기능 조절, 단분자 분광학을 이용한 세포이미징

Cell-nanomaterial interaction, Hypoxia related signaling pathway, Single-molecule fluorescence imaging

대표연구실적

-  S.Y. Kim, M. J. Lee, Y-R. Na, S.Y. Kim, and E. G. Yang, "Visualization of Hypoxia-Inducible Factor 1α-p300 Interactions in Live Cells by Fluorescence Resonance Energy Transfer," accepted in J. Cell. Biochem. (2013) -  Y-R. Na†, S. Y. Kim†, J. T. Gaublomme, A. K. Shalek, M. Jorgolli, H.Park, and E. G.Yang, “Probing Enzyme Activity inside Living Cell Using a Nanowire-Cell “Sandwich” Assay,” Nano Letters 13, 153-158 (2013), †Equally contributed. -  S. Y. Kim, Z. Gitai, A. Kinkhabwala, L. Shapiro, and W. E. Moerner, “Single Molecules of the Bacterial Actin MreB Undergo Directed Treadmilling Motion in Caulobacter crescentus,” Proc. Nat. Acad. Sci. (USA) 103, 10929-10934 (2006).

논문(최근 5년)

-  Protein Kinase C Isoforms Differentially Regulate Hypoxia-Inducible Factor-1α Accumulation in Cancer Cells[Journal of cellular biochemistry,2015-08-01] -  The actions of HIF-3α variants on HIF-2α and HIF-1? heterodimer formation is directly probed in live cells[Experimental cell research,2015-08-01] -  Neuron-like differentiation of mesenchymal stem cells on silicon nanowires[Nanoscale,2015-10-01] -  Pyrithione Zn selectively inhibits hypoxia-inducible factor prolyl hydroxylase PHD3[Biochemical and biophysical research communications,2016-04-01] -  Probing protein complexes inside living cells using a silicon nanowire-based pull-down assay[Nanoscale,2016-06-01] -  Recent Advances in Developing Inhibitors for Hypoxia-Inducible Factor Prolyl Hydroxylases and Their Therapeutic Implications[Molecules,2015-11-01] -  Veritical nanocolumn-assisted pluripotent stem cell colony formation with minimal cell-penetration[Nanoscale,2016-11-01] -  Inflammatory hypoxia induces syndecan-2 expression through IL-1 beta-mediated FOXO3a activation in colonic epithelia[The FASEB journal : official publication of the Federation of American Societies for Experimental Biology,2017-09-01] -  Reversible regulation of enzyme activity by pH-responsive encapsulation in DNA nanocages[ ACS NANO,2017-09-01] -  p21-activated kinase 4 regulates HIF-1 alpha translation in cancer cells[ BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2017-04-01]

특허(최근 5년)

-  HIF-1 알파와 p300 단백질과의 결합을 실시간 분석하는 방법[2014-08-22] -  나노와이어를 이용하여 세포 내의 생체물질을 포획하는 방법 및 이를 이용한 생체물질 분석[2015-10-20]