연구분야
세포 정량 생물학
Cellular Quantitative Biology
대표연구실적
- Kim J, Lee H, Lee JH, Kwon DY, Genovesio A, Fenistein D, Ogier A, Brondani V, Grailhe R. Dimerization, oligomerization, and aggregation of human Amyotrophic lateral sclerosis Cu/Zn-superoxide dismutase 1 mutant forms in live cells. J Biol Chem. 2014.0
- Kim J, Li X, Kang MS, Im KB, Genovesio A, and Grailhe R Quantification of protein interaction in living cells by two photon spectral imaging with fluorescent protein FRET pair devoid of acceptor bleed-through. Cytometry A. 2012.02.01
- Kim J, Lee JH, Kwon D, Lee H, and Grailhe R A comparative analysis of resonance energy transfer methods for Alzheimer related protein-protein interactions in living cells. Mol Biosyst. 2011.11.01
논문(최근 5년)
- Dimerization oligomerization and aggregation of human Amyotrophic lateral sclerosis Cu/Zn-superoxide dismutase 1 mutant forms in live cells[J.Biol.Chem.,2014-05-23]
- A pathway-based approach for identifying biomarkers of tumor progression to trastuzumab-resistant breast cancer[Cancer Lett,2015-01-28]
- Nanoluciferase signal brightness using furimazine substrates opens bioluminescence resonance energy transfer to widefield microscopy[ CYTOMETRY PART A,2016-05-03]
- Assay Development for High Content Quantification of Sod1 Mutant Protein Aggregate Formation in Living Cells[ JOVE-JOURNAL OF VISUALIZED EXPERIMENTS,2017-08-27]
- Regulation of NF-κB by the p105-ABIN2-TPL2 complex and RelAp43 during rabies virus infection[ PLOS PATHOGENS,2017-12-01]
- Glioblastoma-secreted soluble CD44 activates tau pathology in the brain[ EXPERIMENTAL AND MOLECULAR MEDICINE,2017-12-01]
- FLIM-FRET analyzer: open source software for automation of lifetime-based FRET analysis[Source Code for Biology and Medicine,2017-12-01]
특허(최근 5년)
- Centrifuge Accessory for transfer of liquids[2018-10-15]
연구과제 수행 실적
바이러스 감염에 따른 숙주 선천성 면역 단백질 네트워크의 재배열 연구를 위한 단백질-단백질 상호 작용 플랫폼의 구축
High-throughput 표현형 분석기술을 기반으로 한 siRNA microarray chip 플랫폼 개발/최적화 및 유용 유전자 발굴