본문 바로가기 대메뉴 바로가기
Regis Grailhe 교수

Regis Grailhe

INFO

  • 소속캠퍼스한국파스퇴르연구소
  • 전공 바이오-메디컬 융합
    (생물화학)
  • 연락처031-8018-8260
  • 출신전공Molecular biology
  • 학위박사
  • 최종출신대학Strasbourg 1(Universite Louis Pasteur)
  • 이메일

연구분야

세포 정량 생물학

Cellular Quantitative Biology

대표연구실적

-  Kim J, Lee H, Lee JH, Kwon DY, Genovesio A, Fenistein D, Ogier A, Brondani V, Grailhe R. Dimerization, oligomerization, and aggregation of human Amyotrophic lateral sclerosis Cu/Zn-superoxide dismutase 1 mutant forms in live cells. J Biol Chem. 2014.0 -  Kim J, Li X, Kang MS, Im KB, Genovesio A, and Grailhe R Quantification of protein interaction in living cells by two photon spectral imaging with fluorescent protein FRET pair devoid of acceptor bleed-through. Cytometry A. 2012.02.01 -  Kim J, Lee JH, Kwon D, Lee H, and Grailhe R A comparative analysis of resonance energy transfer methods for Alzheimer related protein-protein interactions in living cells. Mol Biosyst. 2011.11.01

논문(최근 5년)

-  Dimerization oligomerization and aggregation of human Amyotrophic lateral sclerosis Cu/Zn-superoxide dismutase 1 mutant forms in live cells[J.Biol.Chem.,2014-05-23] -  Bimolecular fluorescence complementation; lighting-up tau-tau interaction in living cells[PLos One,2013-12-02] -  Contactin 4 -5 and -6 differentially regulate neuritogenesis while they display identical PTPRG binding sites.[Biol.Open,2013-05-15] -  A pathway-based approach for identifying biomarkers of tumor progression to trastuzumab-resistant breast cancer[Cancer Lett,2015-01-28] -  Nanoluciferase signal brightness using furimazine substrates opens bioluminescence resonance energy transfer to widefield microscopy[ CYTOMETRY PART A,2016-05-03] -  Assay Development for High Content Quantification of Sod1 Mutant Protein Aggregate Formation in Living Cells[ JOVE-JOURNAL OF VISUALIZED EXPERIMENTS,2017-08-27] -  Regulation of NF-κB by the p105-ABIN2-TPL2 complex and RelAp43 during rabies virus infection[ PLOS PATHOGENS,2017-12-01] -  Glioblastoma-secreted soluble CD44 activates tau pathology in the brain[ EXPERIMENTAL AND MOLECULAR MEDICINE,2017-12-01] -  FLIM-FRET analyzer: open source software for automation of lifetime-based FRET analysis[Source Code for Biology and Medicine,2017-12-01]

연구과제 수행 실적

바이러스 감염에 따른 숙주 선천성 면역 단백질 네트워크의 재배열 연구를 위한 단백질-단백질 상호 작용 플랫폼의 구축 High-throughput 표현형 분석기술을 기반으로 한 siRNA microarray chip 플랫폼 개발/최적화 및 유용 유전자 발굴