본문 바로가기 대메뉴 바로가기
성지혜 교수

Jihye Seong

INFO

  • 소속캠퍼스한국과학기술연구원 스쿨
  • 전공 바이오-메디컬 융합
    (생물화학)
  • 연락처02-958-5904
  • 출신전공
  • 학위
  • 최종출신대학
  • 이메일

연구분야

FRET기반 바이오센서, 라이브 셀 이미징, 광유전학기법 개발, 브레인 맵핑, 뇌질환 기전연구

FRET-based biosensor, Live-cell fluorescence imaging, Brain mapping/imaging, Signaling in Neural diseases

대표연구실적

-  FRET-based Visualization of PDGF Receptor Activation at Membrane Microdomains, Scientific Reports 2017 -  Distinct biophysical mechanisms of focal adhesion kinase mechanoactivation by different extracellular matrix proteins, PNAS 2013 -  Detection of focal adhesion kinase activation at membrane microdomains by fluorescence resonance energy transfer, Nature Communications 2011

논문(최근 5년)

-  Lipid rafts signaling detected by FRET-based molecular biosensors[Journal of the Korean Society for Applied Biological Chemistry,2015-05-12] -  Subcellular and Dynamic Coordination between Src Activity and Cell Protrusion in Microenvironment[ SCIENTIFIC REPORTS,2015-08-11] -  Single molecular force across single integrins dictates cell spreading[Integrative Biology,2015-06-28] -  Distinct mechanisms regulating mechanical force-induced Ca²? signals at the plasma membrane and the ER in human MSCs[eLife,2015-02-10] -  Matrix softness regulates plasticity of tumour-repopulating cells via H3K9 demethylation and Sox2 expression.[Nature Communications,2014-08-06] -  Decipher the dynamic coordination between enzymatic activity and structural modulation at focal adhesions in living cells[ SCIENTIFIC REPORTS,2014-07-24] -  Advanced fluorescent protein-based synapse detectors[Frontiers in Synaptic Neuroscience,2016-06-01] -  Soft matrices downregulate FAK activity to promote growth of tumor-repopulating cells[ BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2017-01-29] -  In-situ coupling between kinase activities and protein dynamics within single focal adhesions[ SCIENTIFIC REPORTS,2016-07-07] -  Pharmacophore-based virtual screening, biological evaluation and binding mode analysis of a novel protease-activated receptor 2 antagonist.[ JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN,2016-09-06] -  Engineered proteins with sensing and activating modules for automated reprogramming of cellular functions[Nature Communications,2017-09-01] -  FRET-based Visualization of PDGF Receptor Activation at Membrane Microdomains[ SCIENTIFIC REPORTS,2017-05-09] -  Identification of actin as a direct proteomic target of berberine using an affinity-based chemical probe and elucidation of its modulatory role in actin assembly[ CHEMICAL COMMUNICATIONS,2017-06-27] -  In silico probing and biological evaluation of SETDB1/ESET-targeted novel compounds that reduce tri-methylated histone H3K9 (H3K9me3) level[ JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN,2017-09-06] -  Discovery of β-Arrestin Biased Ligands of 5-HT7R.[Journal of Medicinal Chemistry,2018-07-20] -  Identification of crizotinib derivatives as potent SHIP2 inhibitors for the treatment of Alzheimer's disease.[EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2018-08-03] -  Activation of RIG-I-mediated antiviral signaling triggers autophagy through the MAVS-TRAF6-Beclin-1 signaling axis[FRONTIERS IN IMMUNOLOGY,2018-09-12] -  Synthesis of N-Alkyl-Carbazole Derivatives as 5-HT7R Antagonists[BULLETIN OF THE KOREAN CHEMICAL SOCIETY,2018-09-01]

특허(최근 5년)

-  대사성 글루타메이트 수용체 1, 5에 활성을 보이는 신규 테트라하이드로티에노[2,3-c]피리딘 유도체[2016-06-20] -  대사성 글루타메이트 수용체 1에 활성을 지닌 신규 아릴 이소옥사졸 유도체[2016-09-30] -  T-형 칼슘 채널 길항제로서의 크로메인 유도체[2016-11-18] -  4-(2-벤질옥시페닐)-1-(피롤리딘-3-일)-1,2,3-트리아졸 화합물[2016-10-05]