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임상민 교수

LIM SANG MIN

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  • 소속캠퍼스한국과학기술연구원 스쿨
  • 전공 바이오-메디컬 융합
    (생물화학)
  • 연락처02-958-5134
  • 출신전공Chemistry and Chemical Biology
  • 학위박사
  • 최종출신대학Harvard University
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연구분야

의약화학, 유기화학 및 화학생물학

Medicinal Chemistry, Organic Chemistry and Chemical Biology

대표연구실적

-  임상민,정유정,이수현,임홍구,태현섭,김병규,박희동,박종훈,홍승우 “Identification of β-Lapachone Analogs as Novel MALT1 Inhibitors to Treat an Aggressive Subtype of Diffuse Large B-cell Lymphoma” Journal of Medicinal Chemistry, 2015년 10월 23일 -  Ting Xie, 임상민, Kenneth D. Westover, Michael E. Dodge, Dalia Ercan, Scott B. Ficarro, Durga Udayakumar, Deepak Gurbani, 태현섭, Steven M. Riddle, 심태보, Jarrod A. Marto, Pasi A. Janne, Craig M. Crews, Nathanael S. Gray “Pharmacological Targeting of the Pseudokinase Her3" Nature Chemical Biology, 2014년 10월 19일 -  임상민, Kenneth D. Westover, Scott B. Ficarro, Rane A. Harrison, 최환근, Michael E. Pacold, Martin Carrasco, John Hunter, 김남두, Ting Xie, 심태보, Pasi A. Janne, Matthew Meyerson, Jarrod A. Marto, John R. Engen, Nathanael S. Gray “Therapeutic Targeting of Oncogenic K-Ras by a Covalent Catalytic Site Inhibitor” Angewandte Chemie International Edition, 2014년 1월 3일

논문(최근 5년)

-  Strategies to Overcome Acquired Resistances Conferred by Mutations in the Kinase Domain of EGFR[FUTURE MEDICINAL CHEMISTRY,2016-05-19] -  Identification of β-Lapachone Analogs as Novel MALT1 Inhibitors to Treat an Aggressive Subtype of Diffuse Large B-cell Lymphoma [ JOURNAL OF MEDICINAL CHEMISTRY,2015-10-23] -  Discovery of wrightiadione as a novel template for the TrkA kinase inhibitors[ BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2015-09-30] -  Development of Small Molecules Targeting the Pseudokinase Her3[ BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2015-05-11] -  Pharmacological Targeting of the Pseudokinase Her3[ NATURE CHEMICAL BIOLOGY,2014-10-19] -  In situ Selectivity Profiling and Crystal Structure of SML-8-73-1, an Active Site Inhibitor of Oncogenic K-Ras G12C [ PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2014-06-17] -  Optimization and biological evaluation of aminopyrimidine-based IκB kinase β inhibitors with potent anti-inflammatory effects[ EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2016-11-10] -  Identification of the First In Silico-designed TREK1 Antagonists that Block Channel Currents Dosedependently[ CHEMICAL BIOLOGY & DRUG DESIGN,2016-12-01] -  Covalent Guanosine Mimetic Inhibitors of G12C KRAS[ACS MEDICINAL CHEMISTRY LETTERS,2017-01-12] -  Small Molecule Selectively Suppresses MYC Transcription in Cancer Cells[ PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2017-03-28] -  Discovery of non-peptidic small molecule inhibitors of cyclophilin D as neuroprotective agents in Ab-induced mitochondrial dysfunction[ JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN,2017-09-14] -  Discovery of thienopyrrolotriazine derivatives to protect mitochondrial function against Aβ-induced neurotoxicity[European journal of medicinal chemistry,2017-12-01] -  In silico-designed novel non-peptidic ABAD L-D hot spot mimetics reverse A-induced mitochondrial impairments in vitro[Chemical biology & drug design,2017-12-01] -  Ligand­controlled Regiodivergent C-H Alkenylation of Pyrazoles and its Application to the Synthesis of Indazoles[Angewandte Chemie international edition,2017-12-18] -  GRP78-targeted in-silico virtual screening of novel anticancer agents[CHEMICAL BIOLOGY & DRUG DESIGN,2018-08-01] -  Identification of crizotinib derivatives as potent SHIP2 inhibitors for the treatment of Alzheimer's disease[EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2018-09-05] -  Synthesis and biological evaluation of pyrrolidine-based T-type calcium channel inhibitors for the treatment of neuropathic pain[JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY,2018-09-20]

특허(최근 5년)

-  Hydrophobically Tagged Small Molecules as Inducers of Protein Degradation[2014-04-24] -  Ras Inhibitors and Uses Thereof[2014-10-02] -  Hydrophobically Tagged Small Molecules as Inducers of Protein Degradation[2015-10-01] -  Ras Inhibitors and Uses Thereof[2016-01-20] -  Ras inhibitors and Uses Thereof[2016-02-18] -  inibidores de ras e usos dos mesmos[2017-07-18]