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노주환 교수

Joo Hwan No

INFO

  • 소속캠퍼스한국파스퇴르연구소
  • 전공 바이오-메디컬 융합
    (생물화학)
  • 연락처010-5326-5760
  • 출신전공Biophysics and Computational Biology
  • 학위박사
  • 최종출신대학University of Illinois, Urbana Champaign
  • 이메일

연구분야

생물화학을 이용한 리슈만편모충 신약 및 신규 표적 발굴

Discovery of novel drug and target using chemical biology

대표연구실적

-  Yang G, Zhu W, Kim K, Byun SY, Choi G, Wang K, Cha JS, Cho HS, Oldfield E, No JH / In Vitro and In Vivo Investigation of the Inhibition of Trypanosoma brucei Cell Growth by Lipophilic Bisphosphonates. / Antimicrob Agents Chemother / 2015.09.21 -  Yang G, Zhu W, Wang Y, Huang G, Byun S, Choi G, Li K, Huang Z, Docampo R, Oldfield E, No JH / In Vitro and In Vivo Activity of Multi-Target Inhibitors Against Trypanosoma brucei. / ACS Infect Dis. / 2015.08.14 -  No JH, de Macedo Dossin F, Zhang Y, Liu YL, Zhu W, Feng X, Yoo JA, Lee E, Wang K, Hui R, Freitas-Junior LH, Oldfield E. / Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity. / Proc Natl Acad Sci / 2012.03.13

논문(최근 5년)

-  Phenolic Constituents of Medicinal Plants with Activity against Trypanosoma brucei.[MOLECULES,2016-04-12] -  From Drug Screening to Target Deconvolution: a Target-Based Drug Discovery Pipeline Using Leishmania Casein Kinase 1 Isoform 2 To Identify Compounds with Antileishmanial Activity.[ ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,2016-04-22] -  Visceral leishmaniasis: Revisiting current treatments and approaches for future discoveries.[ ACTA TROPICA,2016-03-16] -  In Vitro and In Vivo Investigation of the Inhibition of Trypanosoma brucei Cell Growth by Lipophilic Bisphosphonates.[ ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,2015-09-21] -  In Vitro Evaluation of s-Triazine Derivatives for African Trypanosomiasis[ BULLETIN OF THE KOREAN CHEMICAL SOCIETY,2015-08-17] -  Secondary metabolites from Vietnamese marine invertebrates with activity against Trypanosoma brucei and T. cruzi.[MOLECULES,2014-06-11] -  Multitarget drug discovery for tuberculosis and other infectious diseases.[ JOURNAL OF MEDICINAL CHEMISTRY,2014-04-10]

연구과제 수행 실적

트리파노티온 생성효소 표적 항리슈만편모충 저해제 개발 페노믹 기술을 이용한 리슈만 편모충증 선도물질 발굴 및 작용기작 연구