본문 바로가기 대메뉴 바로가기
서행란 교수

Haeng Ran Seo

INFO

  • 소속캠퍼스한국파스퇴르연구소
  • 전공 바이오-메디컬 융합
    (생물화학)
  • 연락처02-3010-2368
  • 출신전공Molecular Biology
  • 학위박사
  • 최종출신대학고려대학교
  • 이메일

연구분야

간암 신약개발 연구

Discovery of new drugs to treat hepatocelluar carcinoma

대표연구실적

-  Mutual regulation between DNA-PKcs and Snail1 leads to increased genomic instability and aggressive tumor characteristics. Cell Death Dis. 28;4:e517 -  Hepatocellular carcinoma-targeted drug discovery through image-based phenotypic screening in co-cultures of HCC cells with hepatocytes. BMC Cancer 16:810 -  Activated hepatic stellate cells play pivotal roles in hepatocellular carcinoma cell chemoresistance and migration in multicellular tumor spheroids. Scientific reports

논문(최근 5년)

-  Roles of Tumor Microenvironment in Hepatocelluar Carcinoma[Current Cancer Therapy Reviews,2015-08-03] -  Hepatocellular carcinoma-targeted drug discovery through image-based phenotypic screening in co-cultures of HCC cells with hepatocytes[BMC CANCER,2016-09-26] -  Activated hepatic stellate cells play pivotal roles in hepatocellular carcinoma cell chemoresistance and migration in multicellular tumor spheroids[SCIENTIFIC REPORTS,2016-11-20] -  TGF-β-independent CTGF induction regulates cell adhesion-mediated drug resistance by increasing collagen I in HCC [ONCOTARGET,2017-02-20] -  A pathway-based approach for identifying biomarkers of tumor progression to trastuzumab-resistant breast cancer.[CANCER LETTERS,2014-10-30] -  CD133 confers cancer stem-like cell properties by stabilizing EGFR-AKT signaling in hepatocellular carcinoma.[CANCER LETTERS,2016-12-19] -  Sulfasalazine attenuates evading anticancer response of CD133-positive hepatocellular carcinoma cells.[JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH,2017-03-03] -  Potential mechanisms of CD133 in cancer stem cells.[LIFE SCIENCES,2017-07-07] -  Patient-derived multicellular tumor spheroids towards optimized treatment for patients with hepatocellular carcinoma.[JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH,2018-05-25] -  Identification of Ras-degrading small molecules that inhibit the transformation of colorectal cancer cells independent of β-catenin signaling.[Experimental and Molecular Medicine,2018-03-06] -  Regulating BRCA1 protein stability by cathepsin S-mediated ubiquitin degradation.[CELL DEATH AND DIFFERENTIATION,2018-06-08] -  Oxytetracycline have the therapeutic efficiency in CD133+ HCC population through suppression CD133 expression by decreasing of protein stability of CD133[SCIENTIFIC REPORTS,2018-10-31] -  Tumor-vasculature development via the endothelial-to-mesenchymal transition after radiotherapy controls CD44v6+ cancer cell and macrophage polarization[NATURE COMMUNICATIONS,2018-11-05] -  Identification of radiation-induced EndMT inhibitors through cell-based phenomic screening[FEBS OPEN BIO,2018-11-05]

특허(최근 5년)

-  SORD as a biomarker for prognosis of liver cancer[2017-09-04] -  간암 치료를 위한 다세포성 종양 구상체 및 이를 이용한 약물 스크리닝 방법[2017-11-23] -  방사선 손상보호 또는 완화, 및 폐섬유화 예방 또는 치료를 위한 약제학적 조성물[2017-12-20] -  방사선 손상 보호 또는 완화, 및 폐섬유화 예방 또는 치료를 위한 약학 조성물[2017-12-20] -  방사선 손상 보호 또는 완화, 및 폐섬유화 예방 또는 치료 용도[2017-12-20]

연구과제 수행 실적

CD133 양성 간암의 항암제 내성 획득기전 연구를 통한 간암치료 타겟 발굴 다세포성 종양 구상체 모델을 이용한 혁신적 간암 치료 타겟 검증 및 선도물질의 발굴 방사선 유도 EndMT 활성억제제 후보물질 개발 한국형 간암 3차원 종양환경 유래 대사 조절 인자 발굴 및 이를 활용한 차세대 항암제 및 신규 타겟 발굴