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양승훈 교수

Seung-Hoon Yang

INFO

  • 소속캠퍼스한국과학기술연구원 스쿨
  • 전공 바이오-메디컬 융합
    (생물화학)
  • 연락처033-650-3602
  • 출신전공생화학, 면역학
  • 학위박사
  • 최종출신대학Weizmann Inst Sci
  • 이메일

연구분야

염증관련 질환 면역시스템 신호전달 기전 연구

Immune network signaling related inflammation disease models

대표연구실적

-  Yang, S.H., Lee, D.K., Shin. J., Lee, S., Baek. S., Kim, J., Jung, H., Hah, J.M., and Kim, Y. Nec-1 alleviates cognitive impairment with reduction in Aβ and tau abnormalities in APP/PS1 mice. EMBO. Mol. Med. 9(1), 61-77 (IF 9.547, JCR 5%), 2017 -  Kang, T.B.*, Yang, S.H.*, Toth, B., Kovalenko, A., and Wallach, D. (2013) Caspase-8 blocks kinase RIPK3-mediated activation of the NLRP3 inflammasome. Immunity 38, 27-40. (IF 24.082, JCR 1%), 2013 -  기술이전 (네크로스타틴-1을 포함하는 치매 치료 또는 예방용 약제학적 조성물, (주)한국파마, 총액 20.4억원)

저서(최근 5년)

-  Aging Mechanisms - Springer Japan[2015-11-01]

논문(최근 5년)

-  Anti-oxidative and Anti-microbial Activities of Purified MPN-1-1 from Persicaria nepalensis (Meisn.) Miyabe[ CURRENT PHARMACEUTICAL BIOTECHNOLOGY,2017-10-01] -  Taurine-carbohydrate derivative stimulates fibrillogenesis of amyloid-β and reduce Alzheimer-like behaviors[ ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY,2017-08-31] -  Nec-1 alleviates cognitive impairment with reduction in Aβ and tau abnormalities in APP/PS1 mice.[ EMBO MOLECULAR MEDICINE,2016-11-18] -  Rapid and sustained cognitive recovery in APP/PS1 transgenic mice by co-administration of EPPS and donepezil.[ SCIENTIFIC REPORTS,2016-10-31] -  Cell surface GRP78 as a biomarker for suppressing metastasis of high-grade gliomas.[ SCIENTIFIC REPORTS,2016-10-07] -  Age-dependent inverse correlations in CSF and plasma amyloid-β(1-42) concentrations prior to amyloid plaque deposition in the brain of 3xTg-AD mice.[ SCIENTIFIC REPORTS,2016-02-02] -  Abnormalities of plasma cytokines and spleen in senile APP/PS1/Tau transgenic mouse model. [ SCIENTIFIC REPORTS,2015-10-27] -  Activation of the NLRP3 inflammasome by proteins that signal for necroptosis.[ METHODS IN ENZYMOLOGY,2014-07-24]