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Pae Ae Nim(Professor)

INFO

  • AffiliationKIST School
  • Majors Division of Bio-Medical Science & Technology
    (Biological Chemistry)
  • Contact Information02-958-5185
  • Major유기화학
  • DegreePh.D.
  • Highest Level of Education고려대학교
  • E-Mail

Field of Research

molecular modeling and medicinal chemistry

Research Results

-  J. Med. Chem. 2012, 55, 2561?2573 -  Eur. J. Med. Chem. 2013, 63, 558-569 -  J. Mol. Graphics & modeling, 2012. 38, 342-353

Treatise

-  Novel quinazoline-urea analogues as modulators for Aβ-induced mitochondrial dysfunction: Design, synthesis, and molecular docking study[European journal of medicinal chemistry,2014-09-01] -  Synthesis and biological evaluation of 1-(isoxazol-5-ylmethylaminoethyl)-4-phenyl tetrahydropyridine and piperidine derivatives as potent T-type calcium channel blockers with antinociceptive effect in a neuropathic pain model[European journal of medicinal chemistry,2014-03-01] -  Facile diverted synthesis of pyrrolidinyl triazoles using organotrifluoroborate: discovery of potential mPTP blockers[Organic & biomolecular chemistry,2014-12-01] -  Synthesis and in Vitro Evaluation of the Antitubercular and Antibacterial Activity of Novel Oxazolidinones Bearing Octahydrocyclopenta[c]pyrrol-2-yl Moieties[Chemical & pharmaceutical bulletin,2014-12-01] -  Synthesis of a series of unsaturated ketone derivatives as selective and reversible monoamine oxidase inhibitors[Bioorganic & medicinal chemistry,2015-10-01] -  Antioxidant and Anti-Inflammatory Activities of a Natural Compound, Shizukahenriol, through Nrf2 Activation[Molecules,2015-09-01] -  Synthesis and biological evaluation of isoxazoline derivatives as potent M1 muscarinic acetylcholine receptor agonists[Bioorganic & medicinal chemistry letters,2015-04-01] -  ABL kinase inhibitory and antiproliferative activity of novel picolinamide based benzothiazoles[Bioorganic & medicinal chemistry letters,2015-05-01] -  Discovery and biological evaluation of tetrahydrothieno[2,?3-?c]?pyridine derivatives as selective metabotropic glutamate receptor 1 antagonists for the potential treatment of neuropathic pain[European journal of medicinal chemistry,2015-06-01] -  Synthesis and biological evaluation of aryl isoxazole derivatives as metabotropic glutamate receptor 1 antagonists: A potential treatment for neuropathic pain[Bioorganic & medicinal chemistry letters,2015-03-01] -  Synthesis of the Tricyclic Ring Structure of Daphnanes via Intramolecular [4 + 3] Cycloaddition/SmI2-Pinacol Coupling[Organic letters,2015-05-01] -  Design, synthesis, in-vitro antiproliferative activity and kinase profileof new picolinamide based 2-amido and ureido quinoline derivatives[European journal of medicinal chemistry,2015-08-01] -  Discovery of 2-aryloxy-4-amino-quinazoline derivatives as novel protease-activated receptor 2 (PAR2) antagonists[Bioorganic & medicinal chemistry,2015-12-01] -  Synthesis and Biologicak Evaluation of 2-Phenylimino-5((5-phenylfuran-2-yl)methylene)thiazolidin-4-ones as IKK2 inhibitors[Bulletin of the Korean Chemical Society,2015-11-01] -  Tubulin Inhibitor Identification by Bioactive Conformation Alignment Pharmacophore-Guided Virtual Screening[Chemical biology & drug design,2015-11-01] -  Isoxazoline, Isoxazole, and Oxadiazole Derivatives as M1 Muscarinic Acetylcholine Receptor Agonists[Bulletin of the Korean Chemical Society,2016-07-01] -  Discovery of a Nanomolar Multikinase Inhibitor (KST016366): A New Benzothiazole derivative with Remarkable Broad Spectrum of Antiproliferative Activity[CHEMMEDCHEM,2016-08-01] -  Novel 5-substituted-2-anilinoquinolines with 3-(morpholino or 4-methylpiperazin-1-yl)propoxy moiety as broad spectrum antiproliferative agents: Synthesis, cell based assays and kinase screening[Bioorganic & medicinal chemistry letters,2016-07-01] -  Design and synthesis of new potent anticancer benzothiazole amides and ureas featuring pyridylamide moiety and possessing dual B-RafV600E and C-Raf kinase inhibitory activities[European journal of medicinal chemistry,2016-06-01] -  Synthesis and biological evaluation of picolinamides and thiazole-2-carboxamides as mGluR5 (metabotropic glutamate receptor 5) antagonists[ BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2016-01-02] -  Screening, Synthesis, and In Vitro Evaluation of Vinyl Sulfones as Inhibitors of Complement-Dependent Cytotoxicity in Neuromyelitis Optica[CHEMMEDCHEM,2016-02-01] -  Pharmacophore-based virtual screening, biological evaluation and binding mode analysis of a novel protease-activated receptor 2 antagonist[ JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN,2016-08-01] -  Novel Scaffold Identification of mGlu1 Receptor Negative Allosteric Modulators Using a Hierarchical Virtual Screening Approach[ CHEMICAL BIOLOGY & DRUG DESIGN,2016-02-01] -  Immunomodulatory Activities of the Benzoxathiole Derivative BOT-4-One Ameliorate Pathogenic Skin Inflammation in Mice[ JOURNAL OF INVESTIGATIVE DERMATOLOGY,2016-01-01] -  Discovery of a broad spectrum antiproliferative agent with selectivity for DDR1 kinase: cell line-based assay, kinase panel, molecular docking, and toxicity studies[ JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY,2016-01-01] -  Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010?2015; part 1)[EXPERT OPINION ON THERAPEUTIC PATENTS,2016-11-01] -  Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010 - 2015; part 2) [EXPERT OPINION ON THERAPEUTIC PATENTS,2016-11-01] -  Identification of the first in silico-designed TREK1 antagonists that block channel currents dose dependently[ CHEMICAL BIOLOGY & DRUG DESIGN,2016-12-01] -  α-Pinene, a Major Constituent of Pine Tree Oils, Enhances Non-Rapid Eye Movement Sleep in Mice through GABAA-benzodiazepine Receptors[ MOLECULAR PHARMACOLOGY,2016-11-01] -  "Design and synthesis of new 2-anilinoquinolines[ CHEMICAL BIOLOGY & DRUG DESIGN,2017-01-02] -  Discovery of benzimidazole derivatives as modulators of[ EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2017-01-01] -  Remodeling of heterochromatin structure slows neuropathological progression and prolongs survival in an animal model of Huntington’s disease[Acta neuropathologica,2017-11-01] -  Synthesis and evaluation of biaryl derivatives for structural characterization of selective monoamine oxidase B Inhibitors toward Parkinson’s disease therapy[Bioorganic & medicinal chemistry,2018-01-01] -  Direct interaction with 14-3-3 gamma promotes surface expression of Best1 channel in astrocyte[Molecular Brain,2017-11-01] -  Discovery of thienopyrrolotriazine derivatives to protect mitochondrial function against Aβ-induced neurotoxicity[European journal of medicinal chemistry,2017-12-01] -  In silico-designed novel non-peptidic ABAD L-D hot spot mimetics reverse A-induced mitochondrial impairments in vitro[Chemical biology & drug design,2017-12-01] -  Novel LCK/FMS inhibitors based on phenoxypyrimidine scaffold as potential treatment for inflammatory disorders[European journal of medicinal chemistry,2017-12-01] -  Synthesis and evaluation of new pyridyl/pyrazinyl thiourea derivatives: Neuroprotection against amyloid-β-induced toxicity[European journal of medicinal chemistry,2017-12-01]

Patent

-  T-형 칼슘 채널 길항제로서의 5-(치환된알킬아미노메틸)아이속사졸계 화[2014-04-21] -  mGluR5 길항제로서의 2-(아릴에티닐)퀴놀린 유도체 [2014-07-03] -  미토콘드리아 기능 조절에 활성을 지닌 트리아졸 유도체[2014-08-04] -  세로토닌 5-HT3A 길항적 효과를 갖는 퀴나졸린 유도체 함유 약제 조성물[2014-06-10] -  mGluR5 길항제로서의 2-(아릴에티닐)퀴놀린 유도체 [2015-02-03] -  벤조아릴우레이도 화합물, 및 이를 함유하는 퇴행성 뇌질환 예방 또는 치료용 조성물[2014-11-21] -  신경보호제로서의 유레아 유도체[2015-01-07] -  칼슘이온 채널 조절제로서 유효한 피라졸-아자바이사이클로[3.1.0]헥산 화합물 및 이의 약학적 조성물[2014-11-25] -  칼슘이온 채널 조절제로서 유효한 피라졸-아자바이사이클로[3.1.0]헥산 화합물 및 이의 약학적 조성물[2015-09-22] -  테트라베나진과 다이하이드로테트라베나진 제조[2015-03-31] -  세포내 타우 단백질의 상호작용을 모니터링하기 위한 이분자 형광 상보성 아미노산 서열 쌍[2015-08-17] -  벤조아릴우레이도 화합물, 및 이를 함유하는 퇴행성 뇌질환 예방 또는 치료용 조성물[2015-04-21] -  mGluR5의 표식용 방사성 조성물[2015-12-16] -  2,4,6-삼치환된 테트라하이드로파이란 유도체의 입체 선택적 제조방법[2015-11-02] -  대사성 글루타메이트 수용체 1, 5에 활성을 보이는 신규 테트라하이드로티에노[2,3-c]피리딘 유도체[2016-06-20] -  대사성 글루타메이트 수용체 1에 활성을 지닌 신규 아릴 이소옥사졸 유도체[2016-09-30] -  T-형 칼슘 채널 길항제로서의 크로메인 유도체[2016-11-01] -  4-(2-벤질옥시페닐)-1-(피롤리딘-3-일)-1,2,3-트리아졸 화합물[2016-10-05] -  알파-아미노아미드 유도체 화합물 및 이를 포함하는 약학적 조성물[2016-11-21] -  신규한 퀴놀린 유도체 및 이를 포함하는 암의 예방 또는 치료용 약학 조성물 [2017-09-11] -  5-HT2C 수용체 특이적 양성자방출단층촬영용 방사성 추적자 합성 방법[2018-02-07] -  구굴스테론 유도체를 포함하는 신독성 감소용 조성물[2018-01-19]