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Yang, Beom-Seok(Professor)

INFO

  • AffiliationKIST School
  • Majors Division of Bio-Medical Science & Technology
    (Biological Chemistry)
  • Contact Information02-958-5147
  • Major생화학
  • DegreePh.D.
  • Highest Level of EducationMichigan State University
  • E-Mail

Field of Research

Cell signaling, Pathological mechanism of fibroinflammatory diseases, Cancer metastasis, Skin science, Drug Discovery

Research Results

-  Sun X, Phan TN, Jung SH, Kim SY, Cho JU, Lee H, Woo SH, Park TK, and Yang BS. 2012, LCB 03-0110, a novel pan-discoidin domain receptor/c-Src family tyrosine kinase inhibitor, suppresses scar formation by inhibiting fibroblast and macrophage activation. J Pharmacol Exp Ther. 340(3):510-519. -  Jung SH, Sun X, Ryu WS, and Yang BS. 2013, Topical administration of the pan-Src kinase inhibitors, dasatinib and LCB 03-0110, prevents allergic contact dermatitis in mice. Br J Dermatol. 168(1):112-119. -  Phan TN, Wong EL, Sun X, Kim GW, Jung SH, Yoon CN, Yang BS. 2013, A low stability and a conserved N-glycosylation site are associated with regulation of discoidin domain receptor family by glucose via post-translational N-glycosylation. Bioscien. Biotech. Biochem. 77(9):1907-16

Treatise

-  Topical application of ALK5 inhibitor A-83-01 reduces burn wound contraction in rats by suppressing myofibroblast population[Bioscience, biotechnology, and biochemistry,2014-11-01] -  Defective Ca(2+) binding in a conserved binding site causes incomplete N-glycan processing and endoplasmic reticulum trapping of discoidin domain receptors[ BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY,2015-04-01]

Patent

-  복수의 타이로신 카이네이즈에 대한 저해 활성을 가지는 항염증 화합물 및 이를 포함하는 약학적 조성물[2014-09-12] -  복수의 타이로신 카이네이즈에 대한 저해 활성을 가지는 항염증 화합물 및 이를 포함하는 약학적 조성물[2014-12-24] -  피부 노화 방지 또는 피부 상태 개선용 조성물[2015-07-22] -  복수의 타이로신 카이네이즈에 대한 저해 활성을 가지는 항염증 화합물 및 이를 포함하는 약학적 조성물[2015-06-23] -  복수의 타이로신 카이네이즈에 대한 저해 활성을 가지는 항염증 화합물 및 이를 포함하는 약학적 조성물[2016-04-20]