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Roh Eun Joo(Professor)

INFO

  • AffiliationKIST School
  • Majors Division of Bio-Medical Science & Technology
    (Biological Chemistry)
  • Contact Information02-958-6779
  • Major약학과
  • DegreePh.D.
  • Highest Level of Education서울대학교
  • E-Mail

Field of Research

Medicinal chemistry

Research Results

-  Discovery of potent and selective rhodanine type IKKβ inhibitors by hit-to-lead strategy -  Lead discovery and optimization of t-type calcium channel blockers -  P2Y1 Antagonists: Combining Receptor-Based Modeling and QSAR for a Quantitative Prediction of the Biological Activity Based on Consensus Scoring

Treatise

-  Determination of Edible Vegetable Oil Adulterants in Sesame Oil Using 1H Nuclear Magnetic Resonance Spectroscopy[Analytical letters,2014-07-01] -  Structure-based optimization and biological evaluation of trisubstituted pyrazole as a core structure of potent ROS1 kinase inhibitors[Bioorganic & medicinal chemistry,2014-08-01] -  Novel quinazoline-urea analogues as modulators for Aβ-induced mitochondrial dysfunction: Design, synthesis, and molecular docking study[European journal of medicinal chemistry,2014-09-01] -  Design and synthesis of new [1,2,3]Triazolo[4,5-d]pyrimidine derivatives as potential antiproliferative agents[Bulletin of the Korean Chemical Society,2015-06-01] -  Discovery of a broad spectrum antiproliferative agent with selectivity for DDR1 kinase: cell line-based assay, kinase panel, molecular docking, and toxicity studies[Journal of enzyme inhibition and medicinal chemistry,2015-03-01] -  Synthesis of Quinolinylaminopyrimidines and Quinazolinylmethylaminopyrimidines with Antiproliferative Activity against Melanoma Cell Line [Journal of enzyme inhibition and medicinal chemistry,2015-08-01] -  Discovery of potent and selective cytotoxic activity of new quinazoline-ureas against TMZ-resistant glioblastoma multiforme[European Journal of Medicinal Chemistry,2015-08-04] -  Synthesis and Biologicak Evaluation of 2-Phenylimino-5((5-phenylfuran-2-yl)methylene)thiazolidin-4-ones as IKK2 inhibitors[Bulletin of the Korean Chemical Society,2015-11-01] -  Targeting EGFR-HER2 tyrosine kinases with a new potent series of 6-substituted 4-anilinoquinazoline hybrids: Design, synthesis, kinase assay, cell-based assay, and molecular docking[Bioorganic & medicinal chemistry letters,2015-11-01] -  Synthesis of Novel Arylaminoquinazolinylurea Derivatives and Their Antiproliferative Activities against Bladder Cancer Cell Line[ BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2016-10-03] -  Discovery of a broad spectrum antiproliferative agent with selectivity for DDR1 kinase: cell line-based assay, kinase panel, molecular docking, and toxicity studies[ JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY,2016-01-04] -  Trifluoperazine, a Well-Known Antipsychotic,[MOLECULAR CANCER THERAPEUTICS,2017-01-01] -  Discovery of 1-(3-(benzyloxy)pyridin-2-yl)-3-(2-(piperazin-1-yl)[ EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2017-03-10] -  Hit discovery of 4-amino-N-(4-(3-(trifluoromethyl)phenoxy)pyrimidin-5-yl)benzamide: A novel EGFR inhibitor from a designed small library[Bioorganic chemistry,2017-12-01] -  Novel LCK/FMS inhibitors based on phenoxypyrimidine scaffold as potential treatment for inflammatory disorders[European journal of medicinal chemistry,2017-12-01] -  Synthesis and evaluation of new pyridyl/pyrazinyl thiourea derivatives: Neuroprotection against amyloid-β-induced toxicity[European journal of medicinal chemistry,2017-12-01]

Patent

-  단가아민 재흡수 억제 활성을 보이는 (1S,3aR,9bS)-1-페닐-2,3,3a,4,5,9b-헥사하이드로-1H-벤조[e]인돌 유도체와 3,4-다이아릴피롤리딘-2-온 유도체[2014-03-21] -  4각 고리 질소 화합물, 이를 포함하는 우울증, 정신 질환, 조루증, 또는 신경병증성 통증의 예방 또는 치료용 약학 조성물, 및 상기 약학 조성물을 포함하는 제제[2014-07-29] -  미토콘드리아 기능 조절제로서의 벤즈이미다졸 유도체[2014-08-22] -  (+)-렌티지노신의 신규 제조 방법[2014-12-22] -  (+)-폴리옥사믹산의 제조방법[2014-11-20] -  (+)-폴리옥사믹산의 제조방법[2014-10-28] -  벤조아릴우레이도 화합물, 및 이를 함유하는 퇴행성 뇌질환 예방 또는 치료용 조성물[2014-11-21] -  신경보호제로서의 유레아 유도체[2015-01-07] -  클로라이드 채널 차단제로 유용한 화합물[2014-11-17] -  페녹시프로판올 유도체 및 이를 함유하는 약학적 조성물[2014-12-18] -  벤조아릴우레이도 화합물, 및 이를 함유하는 퇴행성 뇌질환 예방 또는 치료용 조성물[2015-04-21] -  다양한 암세포에 대한 활성을 가지는 퀴나졸린 유레아 유도체[2015-12-21] -  항암활성을 가지는 페노싸이아진 유도체 또는 이의 약학적으로 허용 가능한 염, 이의 제조방법 및 이를 유효성분으로 하는 약학적 조성물[2016-08-03] -  아릴옥시 아제티딘 화합물, 이를 포함하는 우울증, 정신 질환, 조루증, 또는 신경병증성 통증의 예방 또는 치료용 약학 조성물, 및 상기 약학 조성물을 포함하는 제제[2016-08-23] -  클로라이드 채널 차단제로 유용한 화합물[2017-12-05]