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Rhim, Hyewhon(Professor)

INFO

  • AffiliationKIST School
  • Majors Division of Bio-Medical Science & Technology
    (Neuroscience)
  • Contact Information02-958-7011
  • Major신경생리학
  • DegreePh.D.
  • Highest Level of EducationUniversity of Chicago
  • E-Mail

Field of Research

Neurobiology ; Physiological Pharmacy ; Medical Sciences

Research Results

-  Lee, M. S., Kim, Y. H., Park, W. S., Park, O. K., Kwon, S., Hong, K., H. Rhim, I. Shim, K. Morita, D. L .Wong, P. D. Patel, D. M. Lyons, A. F. Schatzberg & Her. S./ Temporal variability of glucocorticoid receptor activity is functionally important for the therapeutic action of fluoxetine in the hippocampus./ Molecular psychiatry/2014.09 -  Kim J, Kim Y, Tae J, Yeom M, Moon B, Huang XP, Roth BL, Lee K, Rhim H, Choo IH, Chong Y, Keum G, Nam G, Choo H/ Aryl Biphenyl-3-ylmethylpiperazines as 5-HT7 Receptor Antagonists./ ChemMedChem./2013. 11 -  Kim, S. H., Kim, D. H., Lee, K. H., Im, S. K., Hur, E. M., Chung, K. C., & Rhim, H./ Direct Interaction and functional coupling between human 5-HT6 receptor and the light chain 1 subunit of the microtubule-associated protein 1B (MAP1B-LC1)./ PloS one /2014. 02

Treatise

-  Discovery of aryl-biphenyl-2-ylmethylpiperazines as novel scaffolds for 5-HT7 ligands and role of the aromatic substituents in binding to the target receptor[Bioorganic & medicinal chemistry,2013-05-01] -  Synthesis and the 5-HT6 receptor antagonistic effect of 3-arylsulfonylamino-5,6-dihydro-6-substituted pyrazolo[3,4]pyridinones for neuropathic pain treatment[Bioorganic & medicinal chemistry letters,2013-08-01] -  Novel N-biphenyl-2-ylmethyl 2-methoxyphenylpiperazinylalkanamides as 5-HT7R antagonists for the treatment of depression[Bioorganic & medicinal chemistry,2014-09-01] -  Effects of Ginsenoside Rg3 on α9α10 Nicotinic Acetylcholine Receptor-Mediated Ion Currents[Biological & pharmaceutical bulletin ,2013-05-01] -  Molecular Mechanisms of Large-Conductance Ca2+-Activated Potassium Channel Activation by Ginseng Gintonin[EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013-04-01] -  An increase in voltage-gated sodium channel current elicits microglial activation followed inflammatory responses in vitro and in vivo after spinal cord injury[GLIA,2013-11-01] -  Direct Interaction and Functional Coupling between Human 5-HT6 Receptor and the Light Chain 1 Subunit of the Microtubule-Associated Protein 1B (MAP1B-LC1)[PLoS ONE ,2014-03-01] -  Design and synthesis of novel series of 5-HT6 receptor ligands having indole, a central aromatic core and 1-amino-4 methyl piperazine as a positive ionizable group[Bioorganic & medicinal chemistry,2013-09-01] -  Aryl Biphenyl-3-ylmethylpiperazines as 5-HT7 Receptor Antagonists[CHEMMEDCHEM,2013-11-01] -  In vitro cytotoxicity on human ovarian cancer cells by T-type calcium channel blockers[Bioorganic & medicinal chemistry letters,2013-12-01] -  Vertical nanowire probes for intracellular signaling of living cells[Nanoscale research letters,2014-02-01] -  Synthesis and biological evaluation of isoxazoline derivatives as potent M1 muscarinic acetylcholine receptor agonists[Bioorganic & medicinal chemistry letters,2015-04-01] -  Temporal variability of glucocorticoid receptor activity is functionally important for the therapeutic action of fluoxetine in the hippocampus[Molecular psychiatry,2016-02-01] -  Novel N-acyl-carbazole derivatives as 5-HT7R antagonists[European journal of medicinal chemistry,2016-03-01] -  Isoxazoline, Isoxazole, and Oxadiazole Derivatives as M1 Muscarinic Acetylcholine Receptor Agonists[Bulletin of the Korean Chemical Society,2016-07-01] -  Gintonin absorption in intestinal model systems[Journal of Ginseng Research,2018-01-01]

Patent

-  칼슘채널 조절제로서 유효한 이미다졸릴알킬카르보닐 유도체 및 그의 제조방법[2013-07-23] -  세로토닌 6 수용체 리간드 고효율 검색 및 광범위 특성 연구용 N-terminal HA-tagged 5-HT6R HEK293 세포주[2013-04-03] -  T-형 칼슘 채널 길항제로서의 5-(치환된알킬아미노메틸)아이속사졸계 화[2014-04-21] -  T-형 칼슘 채널에 활성을 지닌 신규 1,4-디아제판일 피라졸 유도체 및 이의 제조방법[2013-03-20] -  T-형 칼슘 채널에 활성을 지닌 피라조일 피페리딘 화합물[2013-09-03] -  칼슘이온 채널 조절제로서 유효한 페닐피라졸릴메틸-2-(4-치환된피페리딘-1-일)아세트아마이드 유도체[2013-07-31] -  세로토닌 5-HT3A 길항적 효과를 갖는 퀴나졸린 유도체 함유 약제 조성물[2014-06-10] -  벤조아릴우레이도 화합물, 및 이를 함유하는 퇴행성 뇌질환 예방 또는 치료용 조성물[2014-11-21] -  세로토닌 5-HT6저해 활성을 갖는 5-설포닐아미노-5,6-다이하이드로-1H-피라졸로[3,4-c]피리딘-7(4H)-온 화합물[2014-11-03] -  벤조아릴우레이도 화합물, 및 이를 함유하는 퇴행성 뇌질환 예방 또는 치료용 조성물[2015-04-21] -  하나의 탐침을 사용하여 전기생리적으로 확인된 뇌 부위에 정확히 약물을 주입하는 방법[2018-01-19]