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Yunkyung kim(Professor)

INFO

  • AffiliationKIST School
  • Majors Division of Bio-Medical Science & Technology
    (Biological Chemistry)
  • Contact Information02-958-5072
  • Major
  • Highest Level of Education
  • E-Mail

Field of Research

neurodegenerative disorder, brain imaging

Research Results

-  임성수, 마무눌하크, 수동동, 김도희, 이준석, 장영태, 김윤경/ Development of a BODIPY-based fluorescent probe for imaging pathological tau aggregates in live cells/ Chemical Communication/ 2017 -  김도희, 전재하, 정은지, 김동진, 류훈, 서혜명, 김윤경/Neuroanatomical Visualization of the Impaired Striatal Connectivity in Huntington’s Disease Mouse Model/ Molecular neurobiology/2016.04 -  김도희, 임성수, 마무눌하크, 류나연, 홍현석, 임혜원, 이동은, 이준석, 정은지, 김동진, 김윤경/ Identi cation of disul de cross-linked tau dimer responsible for tau propagation/Scientific Report/ 2015.05

Book(in last five years)

-  Intracellular tau modifications and cell-based sensors for monitoring tau aggregation[2015-02-13] -  치매, 퇴행성 뇌질환의 새로운 치료 표적, 타우[2016-08-01] -  Image-based analysis of intracellular tau aggregation by using tau-BiFC cell model[2016-12-15]

Treatise

-  Inhibition of tau aggregation by a rosamine derivative that blocks tau intermolecular disulfide cross-linking [Amyloid,2014-06-12] -  Diversity Oriented Fluorescence Library Approach (DOFLA) for Live Cell Imaging Probe Development[Accounts of chemical research,2014-04-01] -  Cell-based Models To Investigate Tau Aggregation[Computational and Structural Biotechnology Journal,2014-10-02] -  Neuroanatomical Visualization of the Impaired Striatal Connectivity in Huntington’s Disease Mouse Model[Molecular Neurobiology,2016-05-15] -  Direct cellular delivery of human proteasomes to delay tau aggregation[Nature Communications,2014-12-01] -  The development of a nucleus staining fluorescent probe for dynamic mitosis imaging in live cells[Chemical communications,2015-04-01] -  A new thin silicon microneedle with an embedded microchannel for deep brain drug infusion[Sensors and actuators. B, Chemical,2015-03-01] -  Open-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradation[Nature Communications,2016-03-01] -  A curcumin-based molecular probe for near-infrared fluorescence imaging of tau fibrils in Alzheimer’s disease[Organic & biomolecular chemistry,2015-12-01] -  Age-dependent inverse correlations in CSF and plasma amyloid-β(1?42) concentrations prior to amyloid plaque deposition in the brain of 3xTg-AD mice[SCIENTIFIC REPORTS,2016-02-02] -  Development of a BODIPY-based fluorescent probe for imaging pathological tau aggregates in live cells[ CHEMICAL COMMUNICATIONS,2017-01-24] -  Pharmacophore-based virtual screening, biological evaluation and binding mode analysis of a novel protease-activated receptor 2 antagonist[ JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN,2016-09-06] -  Identification of disulfide cross-linked tau dimer responsible for tau propagation[SCIENTIFIC REPORTS,2015-10-15] -  Monitoring of intracellular tau aggregation regulated by OGA/OGT inhibitors[INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2015-08-26] -  Discovery of 2-aryloxy-4-amino-quinazoline derivatives as novel protease-activated receptor 2 (PAR2) antagonists[ BIOORGANIC & MEDICINAL CHEMISTRY,2015-12-01] -  Development of tau PET Imaging Ligands and their Utility in Preclinical and Clinical Studies[Nuclear Medicine and Molecular Imaging,2017-07-07] -  Transcriptome analyses of chronic traumatic encephalopathy show alterations in protein phosphatase expression associated with tauopathy[ EXPERIMENTAL AND MOLECULAR MEDICINE,2017-01-17] -  Metal Ion Effects on Aβ and Tau Aggregation[International journal of molecular sciences,2018-01-01]

Patent

-  타우분자들 간 이황화결합 형성을 억제하는 활성을 갖는 티올 반응성 로사민 유도체 및 이를 유효성분으로 포함하는 약학적 조성물 [2017-04-07] -  비닐설폰 유도체, 이의 약학적으로 허용가능한 염 및 이을 유효성분으로 포함하는 시신경 척추염 예방 또는 치료용 약학조성물 [2017-04-10] -  전이성 타우 단백질 및 이의 제조 방법 [2017-04-05] -  외상성 자극에 반응하는 타우 응집 세포주 [2017-04-11] -  항비만 치료용 가역적 마오비 저해제[2017-06-22] -  Nrf2 활성화 효능의 세스퀴터핀 화합물 및 이를 유효성분으로 포함하는 약학조성물[2017-03-10]