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Lee, Jun-Seok(Professor)

INFO

  • AffiliationKIST School
  • Majors Division of Bio-Medical Science & Technology
    (Biological Chemistry)
  • Contact Information02-958-5092
  • MajorBioorganic Chemistry
  • DegreePh.D.
  • Highest Level of EducationNew York University
  • E-Mail
Personal Homepage

Field of Research

chemical biology, combinatorial chemistry, molecular recognition, molecular evolution

Research Results

-  Bulk aggregation based fluorescence turn-on sensors for selective detection of progesterone in aqueous solution. Hong, S. C.; Murale, D. P.; Lee, M.; Lee, S. M.; Park, J. S.; Lee, J. S.* Angew. Chem. Int. Ed., 2017, 56, 14642 ?14647. -  Discrimination of Avian Influenza Virus using Host-cell Infection Fingerprinting by Sulfinate-based Fluorescence Superoxide Probe. Hong, S. C.; Murale, D. P.; Jang, S. Y.; Haque, M. M.; Seo, M.; Lee, S.; Woo, D. H.; Kwon,J.; Song, C. S.; Kim, Y. K.; Lee, J. S.* Angew. Chem. Int. Ed., 2018, 57, 9716-9721. -  Unbiased proteomic profiling strategy for discovery of bacterial effector proteins reveals that Salmonella protein PheA is a host cell cycle regulator, Na, H.; Yoo, Y. H.; Yoon, C. N.; Lee, J. S.* Chem. Biol., 2015, 22, 453-459.

Treatise

-  Mechanistic elements and critical factors of cellular reprogramming revealed by stepwise global gene expression analyses[STEM CELL RESEARCH,2014-05-01] -  Proteome reactivity profiling for the discrimination of pathogenic bacteria[Chemical communications,2014-04-01] -  Diversity Oriented Fluorescence Library Approach (DOFLA) for Live Cell Imaging Probe Development[Accounts of chemical research,2014-04-01] -  Small-molecule probes elucidate global enzyme activity in a proteomic context[BMB REPORTS,2014-03-01] -  A Small-Molecule Protein?Protein Interaction Inhibitor of PARP1 That Targets Its BRCT Domain[Angewandte Chemie international edition,2015-02-01] -  A small-molecule probe for selective profiling and imaging of monoamine oxidase B activities in models of parkinson's disease[Angewandte Chemie international edition,2015-09-01] -  Diversity-oriented approach for chemical biology[Chemical record,2015-04-01] -  Rational design of a photo-crosslinking BODIPY for in situ protein labeling[Chemical communications,2015-04-01] -  Unbiased Proteomic Profiling Strategy for Discovery of Bacterial Effector Proteins Reveals that Salmonella Protein PheA Is a Host Cell Cycle Regulator[Chemistry & biology,2015-04-01] -  Chemical proteomic identification of T-plastin as a novel host cell response factor in HCV infection[Scientific Reports,2015-04-01] -  In Situ Proteome Profiling and Bioimaging Applications of Small-Molecule Affinity-Based Probes Derived From DOT1L Inhibitors[Chemistry : a European journal,2016-06-01] -  Combinatorial Dansyl Library and its Applications to pH-Responsive Probes[Combinatorial chemistry & high throughput screening,2016-05-01] -  Tetrazole Photoclick Chemistry:Reinvestigating Its Suitability as aBioorthogonalReaction and Potential Applications [Angewandte Chemie international edition,2016-02-01] -  Highly sensitive and selective sugar detection by terahertz nano-antennas[SCIENTIFIC REPORTS,2015-10-01] -  Identification of disulfide cross-linked tau dimer responsible for tau propagation[SCIENTIFIC REPORTS,2015-10-01] -  A Suite of """"Minimalist"""" Photo-Crosslinkers for Live-Cell Imaging and Chemical Proteomics: Case Study with BRD4 Inhibitors[Angewandte Chemie international edition,2017-09-01] -  A chemoselective cleavable fluorescence turn-ON linker for proteomic studies[Chemical communications,2017-12-01] -  A Novel Computational Method for Biomedical Binary Data Analysis: Development of a Thyroid Disease Index Using a Brute-Force Search with MLR Analysis[Bulletin of the Korean Chemical Society,2017-12-01] -  A Vinyl Sulfone-Based Fluorogenic Probe Capable of Selective Labeling of PHGDH in Live Mammalian Cells[Angewandte Chemie international edition,2018-01-01] -  Tetrazole-Based Probes for Integrated Phenotypic Screening, Affinity-Based Proteome Profiling, and Sensitive Detection of a Cancer Biomarker[Angewandte Chemie international edition,2017-11-01] -  Bulk Aggregation Based Fluorescence Turn-On Sensors for Selective Detection of Progesterone in Aqueous Solution[Angewandte Chemie international edition,2017-11-01]

Patent

-  yqjL 유전자 발현 산물의 형광 영상화를 통한 바실러스 서브틸리스 검출 방법[2014-10-21] -  ywbO 유전자 산물을 이용한 바실러스 서브틸리스 검출 방법[2015-02-12] -  브루트포스 탐색을 위한 디지털 데이터의 실수형 데이터 변환 방법[2015-08-13] -  단실 구조의 신규 하이드로젠 퍼옥사이드 센서의 합성방법과 이를 활용한 하이드로젠 퍼옥사이드 탐지법[2016-11-01] -  형광바코드를 활용한 병원균 구별법[2017-09-25] -  단백질 표지를 위한 광가교성 기반의 HBT 유도체 [2017-11-21] -  BODIPY 유도체, 그 제조방법 및 이를 이용한 미토콘드리아 표지방법[2018-01-29] -  세포주 기반 AI 바이러스 검출 및 동정 시스템[2017-11-07] -  순환기계 시계열 의료 및 바이오데이터의 특성 패턴 생성 및 타이핑 방법[2017-12-08]