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Jae Wook Lee(Professor)

INFO

  • AffiliationKIST School
  • Majors Division of Bio-Medical Science & Technology
    (Biological Chemistry)
  • Contact Information033-650-3514
  • Major생유기화학
  • DegreePh.D.
  • Highest Level of EducationNew York University
  • E-Mail

Field of Research

natural product HTS/HCS, medicinal chemistry

Research Results

-  Identification of small molecule activators of cryptochrome T. Hirota, J. W. Lee et. al Science 2012, 337, 1094 -  A Small Molecule Modulates Circadian Rhythms through Phosphorylation of the Period Protein Lee, J. W.; Hirota, T. Angew. Chem. Int. Ed. 2011, 50,10608-10611. -  Stepwise Chemically Induced Cardiomyocyte Specification of Human Embryonic Stem Cells. Gonzalez, R.; Lee, J. W Angew. Chem. Int. Ed. 2011, 50, 11181-11185

Treatise

-  Chemo- and Stereoselective Reduction of β-Keto-α-oximino Nitriles by Using Baker's Yeast[European journal of organic chemistry,2015-02-01] -  Diversity-oriented apporach for chemical biology[Chemical record,2015-02-01] -  Solid-phase Synthesis of Combinatorial 2,4-Disubstituted-1,3,5-Triazine via Amine Nucleophilic Reaction[Bulletin of the Korean Chemical Society,2015-01-01] -  The synthesis of sulforaphane analogues and their protection effect against cisplatin induced cytotoxicity in kidney cells[Bioorganic & medicinal chemistry letters,2015-01-01] -  Protective effect of tetrahydrocurcuin against cisplatin-induced renal damage: in vitro and In vivo studies[Planta medica,2015-03-01] -  Development of small-molecule cryptochrome stablilizer derivatives as modulators of the circadian clock[CHEMMEDCHEM,2015-09-01] -  Synthesis and biological evaluation of chalcone analogues as protective agents against cisplatin-induced cytotoxicity in kideny cells[Bioorganic & medicinal chemistry letters,2015-05-01] -  Diversity-oriented approach for chemical biology[Chemical record,2015-04-01] -  Pontemazines A and B, phenazine derivatives containing a methylamine linkage from Streptomyces sp. UT1123 and their protective effect to HT-22 neuronal cells[Bioorganic & medicinal chemistry letters,2015-11-01] -  Synthesis of pyrazine via chemoselective reduction of β-keto-α-oximino ester using baker’s yeast[Journal of molecular catalysis. B, Enzymatic,2016-01-01] -  Gambogic acid induces apoptotic cell death in T98G glioma cells[Bioorganic & medicinal chemistry letters,2016-02-01] -  Discovery, Synthesis, and Evaluation of 2,4-Diaminoquinazolines as a Novel Class of Pancreatic β-Cell-Protective Agents against Endoplasmic Reticulum (ER) Stress[Journal of medicinal chemistry,2016-08-01] -  Gambogic Acid-induced Autophagy and the MAPK Pathway in T98GGlioblastoma Cells[Bulletin of the Korean Chemical Society,2017-10-01] -  Chemical characterization of cytotoxic indole acetic acid derivative from mulberry fruit (Morus alba L.) against human cervical cancer[Bioorganic chemistry,2018-02-01]

Patent

-  설포라판 유도체를 포함하는 신독성 감소용 조성물[2015-03-03] -  설포라판 유도체를 포함하는 신독성 감소용 조성물[2015-03-03] -  구글스테론 유도체의 제조방법 및 그를 포함하는 항암제 조성물 [2016-07-01] -  등나무 추출물 및 분획을 함유하는 피부 미백 조성물[2018-01-12] -  도시 옥상 식물 재배용 에너지 절약형 지속가능한 저장장치 및 연계된 관수장치 개발 [2018-01-02] -  구굴스테론 유도체를 포함하는 신독성 감소용 조성물[2018-01-19]