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Hur, Wooyoung(Professor)

INFO

  • AffiliationKIST School
  • Majors Division of Bio-Medical Science & Technology
    (Biological Chemistry)
  • Contact Information02-958-5193
  • Major화학
  • DegreePh.D.
  • Highest Level of EducationThe Scripps Research Institute
  • E-Mail

Field of Research

Chemical biology

Research Results

-  Hur W, Sun Z, Jiang T, Mason DE, Peters EC, Zhang DD, Luesch H, Schultz PG, Gray NS. A small-molecule inducer of the antioxidant response element. Chemistry & Biology 2010 May 28 -  Zhou W*, Hur W* (공동 1저자), McDermott U, Dutt A, Xian W, Ficarro SB, Zhang J, Sharma SV, Brugge J, Meyerson M, Settleman J, Gray NS. A structure-guided approach to creating covalent FGFR inhibitors. Chemistry & Biology 2010 Mar 26 -  Hur W, Gray NS. Small molecule modulators of antioxidant response pathway. Current Opinion Chemical Biology. 2011 Feb

Treatise

-  A Discovery Strategy for Selective Inhibitors of c-Src in Complex with the Focal Adhesion Kinase SH3/SH2-binding Region[Chem. Biol. Drug Des.,2014-11-28] -  Patient-derived models of acquired resistance can identify effective drug combinations for cancer[Science,2014-12-19] -  Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors[Proceedings of the National Academy of Sciences of the United States of America,2014-11-01] -  Identification of Novel ROS Inducers: Quinone Derivatives Tethered to Long Hydrocarbon Chains[Journal of medicinal chemistry,2015-05-01] -  Antitumor Effects and Mechanisms of AZD4547 on FGFR2-Deregulated Endometrial Cancer Cells[MOLECULAR CANCER THERAPEUTICS,2015-10-01] -  A benzo[b]thiophene-based selective type 4 S1P receptor agonist[ BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2017-01-01] -  Identification of TG100-115 as a new and potent TRPM7 kinase inhibitor, which suppresses breast cancer cell migration and invasion[ BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS,2017-01-31] -  Identification of the first selective Activin receptor-Like Kinase 1 inhibitor, a reversible version of L-783277[ JOURNAL OF MEDICINAL CHEMISTRY,2017-01-19] -  Structure-activity relationship investigation for benzonaphthyridinone derivatives as novel potent Bruton's tyrosine kinase (BTK) irreversible inhibitors [ EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2017-09-08]

Patent

-  항암 활성을 갖는 신규 피리미딘-4-카르복시산 유도체(Novel Pyrimidine-4-Carboxylic Acid Derivatives Having Anti-tumor Activity)[2017-04-04] -  RET 키나아제 저해제인 신규 3-(이속사졸-3-일)-피라졸로[3,4-d]피리미딘-4-아민 화합물(Novel 3-(isoxazol-3-yl)-pyrazolo[3,4-d]pyrimidin-4-amine compounds as RET kinase inhibitor)[2017-08-02] -  Heteroamine derivatives as protein kinase inhibitors[2017-03-07] -  1,3,7-삼치환된 3,4-다이하이드로피리미도[4,5-d]피리미딘-2(1H)-온 유도체들의 급성골수성백혈병 치료 효능[2018-01-08] -  단백질 키나아제 저해제인 신규 3-(이속사졸-3-일)-피라졸로[3,4-d]피리미딘-4-아민 유도체들의 제조방법 및 약학적 활용[2017-12-19] -  AZD4547 신규 유도체[2018-01-15]