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Jihye Seong(Professor)

INFO

  • AffiliationKIST School
  • Majors Division of Bio-Medical Science & Technology
    (Biological Chemistry)
  • Contact Information02-958-5904
  • Major
  • Highest Level of Education
  • E-Mail

Field of Research

FRET-based biosensor, Live-cell fluorescence imaging, Brain mapping/imaging, Signaling in Neural diseases

Research Results

-  FRET-based Visualization of PDGF Receptor Activation at Membrane Microdomains, Scientific Reports 2017 -  Distinct biophysical mechanisms of focal adhesion kinase mechanoactivation by different extracellular matrix proteins, PNAS 2013 -  Detection of focal adhesion kinase activation at membrane microdomains by fluorescence resonance energy transfer, Nature Communications 2011

Treatise

-  Lipid rafts signaling detected by FRET-based molecular biosensors[Journal of the Korean Society for Applied Biological Chemistry,2015-05-12] -  Subcellular and Dynamic Coordination between Src Activity and Cell Protrusion in Microenvironment[ SCIENTIFIC REPORTS,2015-08-11] -  Single molecular force across single integrins dictates cell spreading[Integrative Biology,2015-06-28] -  Distinct mechanisms regulating mechanical force-induced Ca²? signals at the plasma membrane and the ER in human MSCs[eLife,2015-02-10] -  Matrix softness regulates plasticity of tumour-repopulating cells via H3K9 demethylation and Sox2 expression.[Nature Communications,2014-08-06] -  Decipher the dynamic coordination between enzymatic activity and structural modulation at focal adhesions in living cells[ SCIENTIFIC REPORTS,2014-07-24] -  Advanced fluorescent protein-based synapse detectors[Frontiers in Synaptic Neuroscience,2016-06-01] -  Soft matrices downregulate FAK activity to promote growth of tumor-repopulating cells[ BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2017-01-29] -  In-situ coupling between kinase activities and protein dynamics within single focal adhesions[ SCIENTIFIC REPORTS,2016-07-07] -  Pharmacophore-based virtual screening, biological evaluation and binding mode analysis of a novel protease-activated receptor 2 antagonist.[ JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN,2016-09-06] -  Engineered proteins with sensing and activating modules for automated reprogramming of cellular functions[Nature Communications,2017-09-01] -  FRET-based Visualization of PDGF Receptor Activation at Membrane Microdomains[ SCIENTIFIC REPORTS,2017-05-09] -  Identification of actin as a direct proteomic target of berberine using an affinity-based chemical probe and elucidation of its modulatory role in actin assembly[ CHEMICAL COMMUNICATIONS,2017-06-27] -  In silico probing and biological evaluation of SETDB1/ESET-targeted novel compounds that reduce tri-methylated histone H3K9 (H3K9me3) level[ JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN,2017-09-06] -  Discovery of β-Arrestin Biased Ligands of 5-HT7R.[Journal of Medicinal Chemistry,2018-07-20] -  Identification of crizotinib derivatives as potent SHIP2 inhibitors for the treatment of Alzheimer's disease.[EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2018-08-03] -  Activation of RIG-I-mediated antiviral signaling triggers autophagy through the MAVS-TRAF6-Beclin-1 signaling axis[FRONTIERS IN IMMUNOLOGY,2018-09-12] -  Synthesis of N-Alkyl-Carbazole Derivatives as 5-HT7R Antagonists[BULLETIN OF THE KOREAN CHEMICAL SOCIETY,2018-09-01]

Patent

-  대사성 글루타메이트 수용체 1, 5에 활성을 보이는 신규 테트라하이드로티에노[2,3-c]피리딘 유도체[2016-06-20] -  대사성 글루타메이트 수용체 1에 활성을 지닌 신규 아릴 이소옥사졸 유도체[2016-09-30] -  T-형 칼슘 채널 길항제로서의 크로메인 유도체[2016-11-18] -  4-(2-벤질옥시페닐)-1-(피롤리딘-3-일)-1,2,3-트리아졸 화합물[2016-10-05]