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LIM SANG MIN(Professor)

INFO

  • AffiliationKIST School
  • Majors Division of Bio-Medical Science & Technology
    (Biological Chemistry)
  • Contact Information02-958-5134
  • MajorChemistry and Chemical Biology
  • DegreePh.D.
  • Highest Level of EducationHarvard University
  • E-Mail

Field of Research

Medicinal Chemistry and Organic Chemistry

Research Results

-  임지웅, 김석규, 최서윤, 김동회, Changdev G. Gadhe, 이해님, 김효지, 김진아, 조성진, 황하영, 성지혜, 정규성, 이재열, 임상민, 이재욱, 배애님 "Identification of crizotinib derivatives as potent SHIP2 inhibitors for the treatment of Alzheimer's disease" European Journal of Medicinal Chemistry, 2018년 9월 5일 -  김현태, 하혜리, 강근희, 김옥순, 류호, Abul K. Biswas, 임상민, 백무현, 주정민 "Ligand­-controlled Regiodivergent C-H Alkenylation of Pyrazoles and its Application to the Synthesis of Indazoles" Angewandte Chemie International Edition, 2017년 12월 18일 -  임상민, 정유정, 이수현, 임홍구, 태현섭, 김병규, 박희동, 박종훈, 홍승우 “Identification of β-Lapachone Analogs as Novel MALT1 Inhibitors to Treat an Aggressive Subtype of Diffuse Large B-cell Lymphoma” Journal of Medicinal Chemistry, 2015년 10월 23일

Treatise

-  Strategies to Overcome Acquired Resistances Conferred by Mutations in the Kinase Domain of EGFR[FUTURE MEDICINAL CHEMISTRY,2016-05-19] -  Identification of β-Lapachone Analogs as Novel MALT1 Inhibitors to Treat an Aggressive Subtype of Diffuse Large B-cell Lymphoma [ JOURNAL OF MEDICINAL CHEMISTRY,2015-11-12] -  Discovery of wrightiadione as a novel template for the TrkA kinase inhibitors[ BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2015-11-15] -  Development of Small Molecules Targeting the Pseudokinase Her3[ BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2015-08-15] -  Pharmacological Targeting of the Pseudokinase Her3[ NATURE CHEMICAL BIOLOGY,2014-10-19] -  In situ Selectivity Profiling and Crystal Structure of SML-8-73-1, an Active Site Inhibitor of Oncogenic K-Ras G12C [ PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2014-06-17] -  Optimization and biological evaluation of aminopyrimidine-based IκB kinase β inhibitors with potent anti-inflammatory effects[ EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2016-11-10] -  Identification of the First In Silico-designed TREK1 Antagonists that Block Channel Currents Dose dependently[ CHEMICAL BIOLOGY & DRUG DESIGN,2016-12-01] -  Covalent Guanosine Mimetic Inhibitors of G12C KRAS[ACS MEDICINAL CHEMISTRY LETTERS,2017-01-12] -  Small Molecule Selectively Suppresses MYC Transcription in Cancer Cells[ PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2017-03-28] -  Discovery of non-peptidic small molecule inhibitors of cyclophilin D as neuroprotective agents in Aβ-induced mitochondrial dysfunction[ JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN,2017-09-14] -  Discovery of thienopyrrolotriazine derivatives to protect mitochondrial function against Aβ-induced neurotoxicity[European journal of medicinal chemistry,2017-12-01] -  In silico-designed novel non-peptidic ABAD L-D hot spot mimetics reverse Aβ-induced mitochondrial impairments in vitro[Chemical biology & drug design,2017-12-01] -  Ligand­-controlled Regiodivergent C-H Alkenylation of Pyrazoles and its Application to the Synthesis of Indazoles[Angewandte Chemie international edition,2017-12-18] -  GRP78-targeted in-silico virtual screening of novel anticancer agents[CHEMICAL BIOLOGY & DRUG DESIGN,2018-08-01] -  Identification of crizotinib derivatives as potent SHIP2 inhibitors for the treatment of Alzheimer's disease[EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2018-09-05] -  Synthesis and biological evaluation of pyrrolidine-based T-type calcium channel inhibitors for the treatment of neuropathic pain[JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY,2018-09-20]

Patent

-  Hydrophobically tagged small molecules as inducers of protein degradation[2014-04-24] -  Ras Inhibitors and Uses Thereof[2014-10-02] -  Ras Inhibitors and Uses Thereof[2014-11-27] -  Hydrophobically tagged small molecules as inducers of protein degradation[2015-10-01] -  Ras 억제제 및 그의 용도[2015-11-12] -  Ras Inhibitors and Uses Thereof[2015-11-18] -  Ras Inhibitors and Uses Thereof[2016-02-18] -  Ras Inhibitors and Uses Thereof[2016-05-09] -  Ras Inhibitors and Uses Thereof[2017-02-22] -  Ras Inhibitors and Uses Thereof[2017-04-17] -  Hydrophobically tagged small molecules as inducers of protein degradation[2017-09-12] -  Levosimendan compound for preventing or treating tau-related diseases[2018-05-08] -  타우 관련 질환의 예방 또는 치료용 레보시멘단 화합물[2018-10-15] -  5-HT7 수용체의 조절제로 작용하는 아릴피라졸릴피페라진 또는 아릴피라졸릴다이아제페인의 유도체 및 이를 포함하는 중추신경계 질환 치료 또는 예방용 약학 조성물[2017-12-01] -  척수 손상의 예방 및 치료용 조성물[2018-02-07] -  뇌졸증의 예방 및 치료용 조성물[2018-04-04] -  백화사설초 추출물을 포함하는 신경세포 보호용 조성물[2018-06-19] -  금전초 추출물을 포함하는 신경세포 보호용 조성물[2018-06-19] -  수양버들 추출물을 포함하는 신경세포 보호용 조성물[2018-06-19] -  비수리 추출물을 포함하는 신경세포 보호용 조성물[2018-08-03] -  SHIP2 저해활성을 보이는 신규한 피리딘 유도체 및 이를 유효성분으로 하는 약학 조성물[2018-08-08] -  신규한 할로-(3-(페닐설포닐)프로프-1-에닐)피리딘 유도체 및 이의 용도[2018-08-17] -  T-형 칼슘 채널에 활성을 가지는 피롤리딘 또는 피페리딘 화합물[2018-08-23] -  진세노사이드 Rb2를 포함하는 신경세포 보호용 조성물[2018-10-16]