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SANG-RAE LEE

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  • 소속캠퍼스한국생명공학연구원 스쿨
  • 전공 생명과학
    (기능유전체학)
  • 연락처043-240-6322
  • 출신전공동물자원학
  • 학위박사
  • 최종출신대학단국대학교
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개인홈페이지

연구분야

실험동물의학(영장류)

Laboratory animal medicine(Non-human primate)

대표연구실적

-  Ma S, et al/Organization of the Mammalian Metabolome according to Organ Function, Lineage Specialization, and Longevity/CELL METABOLISM/2015.08.04 -  Yeo HG, et al/Characterization of Cerebral Damage in a Monkey Model of Alzheimer’s Disease Induced by Intracerebroventricular Injection of Streptozotocin/JOURNAL OF ALZHEIMERS DISEASE/2015.03.27 -  Lee Y, et al/Insulin/IGF Signaling-Related Gene Expression in the Brain of a Sporadic Alzheimer's Disease Monkey Model Induced by Intracerebroventricular Injection of Streptozotocin/JOURNAL OF ALZHEIMERS DISEASE/2013.07.07

저서(최근 5년)

-  인류의 가족, 인간의 동반자 영장류[2015-03-31] -  Stem Cell in Clinical Applications; Neurological Regeneration[2017-03-01]

논문(최근 5년)

-  Salutary effects of melatonin combined with treadmill exercise on cartilage damage[JOURNAL OF PINEAL RESEARCH,2014-05-05] -  Progesterone production is affected by unfolded protein response (UPR) signaling during the luteal phase in mice[LIFE SCIENCES,2014-08-07] -  Peroxiredoxin 5 decreases beta-amyloid-mediated cyclin-dependent kinase 5 activation through regulation of Ca2+-mediated calpain activation[ ANTIOXIDANTS & REDOX SIGNALING,2017-09-14] -  Establishment and characterization of immortalized minipig neural stem cell line = 불멸화 미니돼지 신경줄기세포주의 확립 및 특성 분석[ CELL TRANSPLANTATION,2017-02-17] -  Peroxiredoxin 2 regulates PGF2α-induced corpus luteum regression in mice by inhibiting ROS-dependent JNK activation[ FREE RADICAL BIOLOGY AND MEDICINE,2017-04-11] -  Identifiation and characterization of the tyrosinase gene (TYR) and its transcript variants (TYR_1 and TYR_2) in the crab-eating macaque (Macaca fascicularis)[ GENE,2017-08-10] -  Chrysophanol suppresses pro-inflammatory response in microglia via regulation of Drp1-dependent mitochondrial fission[ IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY,2017-08-29] -  Anti-in?ammatory effects of ursolic acid-3-acetate on human synovial ?broblasts and a murine model of rheumatoid arthritis[ INTERNATIONAL IMMUNOPHARMACOLOGY,2017-06-02] -  Melatonin as a novel interventional candidate for fragile X syndrome with autism spectrum disorder in humans[ INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2017-06-26] -  Peroxiredoxin 5 overexpression enhances tumorigenicity and correlates with poor prognosis in gastric cancer[ INTERNATIONAL JOURNAL OF ONCOLOGY,2017-06-28] -  Sustained diffusion reversal with in-bore reperfusion in monkey stroke models: confirmed by prospective magnetic resonance imaging[ JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM,2017-05-31] -  Anti-inflammatory effect of oleuropein on microglia through regulation of Drp1-dependent mitochondrial fission[ JOURNAL OF NEUROIMMUNOLOGY,2017-04-03] -  Beneficial effect of interventional exercise on autistic Fragile X syndrome = 자폐성 취약 X증후군에서 중재운동의 효과[Journal of Physical Therapy Science,2017-04-24] -  Superovulatory responses in cynomolgus monkeys (Macaca fascicularis) depend on the interaction between donor status and superovulation method used[ JOURNAL OF REPRODUCTION AND DEVELOPMENT,2017-04-28] -  Alu-derived alternative splicing events specific to Macaca lineages in CTSF gene[ MOLECULES AND CELLS,2017-03-09] -  Profiling of cytosolic and mitochondrial H2O2 production using the H2O2-sensitive protein HyPer in LPS-induced microglia cells[ NEUROSCIENCE LETTERS,2017-07-10] -  Identification of sennoside A as a novel inhibitor of the slingshot (SSH) family proteins related to cancer metastasis[ PHARMACOLOGICAL RESEARCH,2017-04-04] -  Chrysophanol suppressed glutamate-induced hippocampal neuronal cell death via regulation of dynamin-related protein 1-dependent mitochondrial fission[ PHARMACOLOGY,2017-07-10] -  Dual effect of fetal bovine serum on early development depends on stage-specific reactive oxygen species demands in pigs[ PLOS ONE,2017-04-17] -  Iloprost supports early development of in vitro-produced porcine embryos through activation of the phosphatidylinositol 3-kinase/AKT signalling pathway[ REPRODUCTION FERTILITY AND DEVELOPMENT,2017-07-10] -  2-Hydroxy-3-methoxybenzoic acid attenuates mast cell-mediated allergic reaction in mice via modulation of the FcεRI signaling pathway[ ACTA PHARMACOLOGICA SINICA,2017-01-12] -  Neurorestorative role of stem cells in Alzheimer's disease: astrocyte involvement[ CURRENT ALZHEIMER RESEARCH,2016-04-04] -  Peroxiredoxin 5 (Prx5) decreases LPS-induced microglial activation through regulation of Ca2+/calcineurin-Drp1-dependent mitochondrial fission = 페록시레독신 5 (Prx5)가Ca2+/calcineurin-Drp1-dependent mitochondrial fission을 통하여 LPS로 유발된 마이크로글리아 세포 활성화를 억제하는 기전[ FREE RADICAL BIOLOGY AND MEDICINE,2016-09-13] -  Macaca specific exon creation event generates a novel ZKSCAN5 transcript[ GENE,2016-01-14] -  Mitochondria-targeted DsRed2 protein expression during the early stage of bovine somatic cell nuclear transfer embryo development = 형질전환 체세포를 이용한 복제수정란에서의 초기 배 발생 시기의 미토콘드리아 DNA 확인[ IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL,2016-11-16] -  Identification of alternative variants and insertion of the novel polymorphic AluYl17 in TSEN54 gene during primate evolution[ INTERNATIONAL JOURNAL OF GENOMICS,2016-12-29] -  Human neural stem cells overexpressing a carboxylesterase inhibit bladder tumor growth = 카르복실에스테레이즈를 과발현하는 인간 신경줄기세포의 방광암 성장억제 효과[ MOLECULAR CANCER THERAPEUTICS,2016-06-07] -  Iron overload-induced calcium signals modulate mitochondrial fragmentation in HT-22 hippocampal neuron cells[ TOXICOLOGY,2016-11-30] -  Gene expression defines natural changes in mammalian lifespan[ AGING CELL,2015-05-04] -  Organization of the mammalian metabolome according to organ function, lineage specialization, and longevity[ CELL METABOLISM,2015-08-07] -  Long-term survival and differentiation of human neural stem cells in nonhuman primate brain with no immunosuppression[ CELL TRANSPLANTATION,2015-03-02] -  Improvement in spinal cord injury-induced bladder fibrosis using mesenchymal stem cell transplantation into the bladder wall[ CELL TRANSPLANTATION,2015-08-03] -  Quantitative expression analysis of APP pathway and tau phosphorylation-related genes in the ICV STZ-induced non-human primate model of sporadic Alzheimer’s disease[ INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2015-01-26] -  The incremental induction of neuroprotective properties by multiple therapeutic strategies for primary and secondary neural injury[ INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2015-08-24] -  High-resolution fluorodeoxyglucose positron emission tomography and magnetic resonance imaging findings of a pituitary microtumor in a dog[ IRISH VETERINARY JOURNAL,2015-09-30] -  Characterization of cerebral damage in a monkey model of Alzheimer’s disease induced by intracerebroventricular injection of streptozotocin = 뇌실내 streptozotocin을 주입한 원숭이 알츠하이머병 유발 모델에서 뇌손상의 특성 규명[ JOURNAL OF ALZHEIMERS DISEASE,2015-07-14] -  Comparison of rapid screening immunoassay and intradermal test for canine atopic dermatitis[Journal of Biomedical Research,2015-10-16] -  Loss of mitofusin 2 links beta-amyloid-mediated mitochondrial fragmentation and Cdk5-induced oxidative stress in neuron cells[ JOURNAL OF NEUROCHEMISTRY,2015-03-19] -  Gain of a new exon by a lineage-specific Alu element-integration event in the BCS1L gene during primate evolution[ MOLECULES AND CELLS,2015-11-25] -  Iron overload triggers mitochondrial fragmentation via calcineurin-sensitive signals in HT-22 hippocampal neuron cells[ TOXICOLOGY,2015-09-23] -  Characterization of pig sperm hyaluronidase and improvement of the digestibility of cumulus cell mass by recombinant pSPAM1 hyaluronidase in an in vitro fertilization assay = 돼지 정자의 hyaluronidase 특성 및 체외수정시 재조합 [ ANIMAL REPRODUCTION SCIENCE,2014-11-25] -  Developmental competence of bovine early embryos depends on the coupled response between oxidative and endoplasmic reticulum stress[ BIOLOGY OF REPRODUCTION,2014-07-03] -  Therapeutically targeting neuroinflammation and microglia after acute ischemic stroke[ BIOMED RESEARCH INTERNATIONAL,2014-07-03] -  Alzheimer's disease and stem cell therapy[Experimental Neurobiology,2014-04-21] -  Comparison of surgical methods of transient middle cerebral artery occlusion between rats and mice[ JOURNAL OF VETERINARY MEDICAL SCIENCE,2015-01-26] -  Identification of hyperacute ischemic stroke with a more homogenous nature[ TRANSLATIONAL NEUROSCIENCE,2014-12-24] -  Primary brain involvement of disseminated histiocytic sarcoma in a Rottweiler dog : histopathology, 18 F-fluorodeoxyglucose positron emission tomography and 7 T-magnetic resonance imaging findings - a case repor[ VETERINARNI MEDICINA,2017-01-01] -  Isothiocyanates suppress the invasion and metastasis of tumors by targeting FAK/MMP-9 activity[ ONCOTARGET,2017-01-01] -  Chrysin attenuates atopic dermatitis by suppressing inflammation of keratinocytes[ FOOD AND CHEMICAL TOXICOLOGY,2017-01-01]

특허(최근 5년)

-  게잡이 원숭이의 유전적 다형성[2014-07-10] -  영장류 차량 이동용 케이지 장치[2015-11-27] -  마그네틱을 이용한 형광다중면역검사법[2015-02-16] -  디지토닌을 이용한 정자의 형질전환 방법[2017-02-06] -  LPS가 결여된 아시네토박터 바우마니 유래 외막소포체를 포함하는 항암용 조성물[2016-06-17] -  변형 외막소포체를 포함하는 항감염성 면역증강용 조성물[2016-06-17] -  급성 허혈성 뇌졸중 동물 모델 및 이의 제조방법[2015-05-19] -  스트렙토라이신 O의 처리에 의한 형질전환 동물의 생산성 향상 방법[2016-09-28]