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김용성 교수

Kim, Yong Sung

INFO

  • 소속캠퍼스한국생명공학연구원 스쿨
  • 전공 생명과학
    (기능유전체학)
  • 연락처042-879-8110
  • 출신전공분자유전학
  • 학위박사
  • 최종출신대학성균관대학교 자연과학캠퍼스
  • 이메일

연구분야

암/줄기세포의 후성유전학 및 후성유전체학

Epigenetics & epigenomics in cancer and stem cells

대표연구실적

-  Kim JC, Ha YJ, Tak KH, Roh SA, Kwon YH, Kim CW, Yoon YS, Lee JL, Park Y, Kim SK, Kim SY, Cho DH, Kim YS. Opposite functions of GSN and OAS2 on colorectal cancer metastasis, mediating perineural and lymphovascular invasion, respectively. PLoS One. 2018.09 -  Park JL, Kim JH, E Seo, DH Bae, SY Kim, HC Lee, KM Woo, Kim YS. Identification and evaluation of age-correlated DNA methylation markers for forensic use. FSIGenetics 2016.07 -  Park JL, Kim HJ, Seo EH, Kwon OH, Lim B, Kim M, Kim SY, Song KS, Kang GH, Kim HJ, Choi BY, Kim YS. Decrease of 5hmC in gastric cancers is associated with TET1 silencing due to with DNA methylation and bivalent histone marks at TET1 CpG island 3'-shore. Oncotarget. 2015.11

논문(최근 5년)

-  Epigenetic Regulation of KLHL34 Predictive of Pathologic Response to Preoperative Chemoradiation Therapy in Rectal Cancer Patients[INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS,2015-04-01] -  Gene polymorphisms in the ornithine decarboxylase-polyamine pathway modify gastric cancer risk by interaction with isoflavone concentrations[GASTRIC CANCER,2015-07-01] -  Integrative genomics analysis reveals the multi-level dysregulation and oncogenic characteristics of TEAD4 in gastric cancer.[CARCINOGENESIS,2014-03-05] -  Variable allelic expression of imprinted genes in human pluripotent stem cells during differentiation into specialized cell types in vitro.[BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2014-04-06] -  Intermediate serrated polyp as an intermediate lesion of hyperplastic polyp and sessile serrated polyp/adenoma in terms of morphological and molecular features.[HUMAN PATHOLOGY,2014-08-08] -  Microarray screening and qRT-PCR validation of microRNA markers for forensic body fluid identification.[ELECTROPHORESIS,2014-11-21] -  Differences of Gastric Mucosal Microbiota Profiling in Patients with Chronic Gastritis Intestinal Metaplasia and Gastric Cancer using pyrosequencing methods.[HELICOBACTER,2014-12-19] -  TWEAK/Fn14 signaling mediates gastric cancer cell resistance to 5-fluorouracil via NF-kB activation.[INTERNATIONAL JOURNAL OF ONCOLOGY,2014-04-04] -  Collagen Triple Helix Repeat Containing 1 (CTHRC1) acts via ERK-dependent induction of MMP9 to promote invasion of colorectal cancer cells.[Oncotarget,2014-05-02] -  nc886 a non-coding RNA of anti-proliferative role is suppressed by CpG DNA methylation in human gastric cancer.[Oncotarget,2014-06-15] -  Epigenetic silencing of BTB and CNC homology 2 and concerted promoter CpG methylation in gastric cancer.[CANCER LETTERS,2014-03-05] -  REGNET: mining context-specific transcription networks using composite genomic information.[BMC GENOMICS,2014-06-09] -  Identification of body fluid-specific DNA methylation markers for use in forensic science.[FORENSIC SCIENCE INTERNATIONAL-GENETICS,2014-07-27] -  Single-Nucleotide Polymorphisms in the Vascular Endothelial Growth Factor Pathway and Outcomes of Patients Treated with First-Line Cytotoxic Chemotherapy Combined with Bevacizumab for Advanced Colorec[ONCOLOGY,2014-08-15] -  A nineteen gene-based risk score classifier predicts prognosis of colorectal cancer patients.[MOLECULAR ONCOLOGY,2014-12-08] -  Decrease of 5hmC in gastric cancers is associated with TET1 silencing due to with DNA methylation and bivalent histone marks at TET1 CpG island 3'-shore[Oncotarget,2015-11-04] -  Genome-wide mutation profiles of colorectal tumors and associated liver metastases at the exome and transcriptome levels[Oncotarget,2015-09-03] -  Identification and evaluation of age-correlated DNA methylation markers for forensic use[FORENSIC SCIENCE INTERNATIONAL-GENETICS,2016-10-03] -  Integrated epigenomic analyses of enhancer as well as promoter regions in gastric cancer[Oncotarget,2016-06-01] -  Specific expression and methylation of SLIT1, SLIT2, SLIT3, and miR-218 in gastric cancer subtypes[INTERNATIONAL JOURNAL OF ONCOLOGY,2016-04-01] -  Complex behavior of ALDH1A1 and IGFBP1 in liver metastasis of colorectal cancer[PLOS ONE,2016-05-10] -  Feasibility of novel PPP1R15A and proposed ANXA11 single nucleotide polymorphisms as predictive markers for bevacizumab regimen in metastatic colorectal cancer[JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY,2016-08-10] -  ZKSCAN3 Facilitates Liver Metastasis of Colorectal Cancer Associated with CEA-expressing Tumor[ANTICANCER RESEARCH,2016-05-27] -  Genome-wide DNA methylation profiles altered by Helicobacter pylori in gastric mucosa and blood leukocyte DNA[Oncotarget,2016-10-21] -  Potential forensic application of DNA methylation to identify individuals in a pair of monozygotic twins[FORENSIC SCIENCE INTERNATIONAL-GENETICS,2017-10-10] -  Variability in Chromatin Architecture and Associated DNA Repair at Genomic Positions Containing Somatic Mutations[CANCER RESEARCH,2017-06-14] -  PSMB8 as a candidate marker of responsiveness to preoperative radiation therapy in rectal cancer patients[INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS,2017-08-30] -  Vitamin C Promotes Astrocyte Differentiation Through DNA Hydroxymethylation[STEM CELLS,2018-08-15] -  Inflammation induces two types of inflammatory dendritic cells in inflamed lymph nodes[EXPERIMENTAL AND MOLECULAR MEDICINE,2018-03-02] -  Epigenetic silencing of miR-1271 enhances MEK1 and TEAD4 expression in gastric cancer[CANCER MEDICINE,2018-09-14] -  Opposite functions of GSN and OAS2 on colorectal cancer metastasis, mediating perineural and lymphovascular invasion, respectively[PLOS ONE,2018-09-27] -  Enhancer remodeling and microRNA alterations are associated with acquired resistance to ALK inhibitors[CANCER RESEARCH,2018-06-15] -  Cell-free miR-27a, a potential diagnostic and prognostic biomarker for gastric cancer[Genomics & Informatics,2015-09-30]

연구과제 수행 실적

갑상선암 환자 맞춤 진료를 위한 유전체·후성유전체 통합 진단 플랫폼 구축 당질 유전자교정기술을 이용한 인간모사 마우스모델 개발 사업 미만형 위암의 후성유전체, 전사체 데이터 확보 및 바이오마커 발굴 위암세포 분화단계별 후성유전체 지도 작성 전암 및 조기암 후성유전체 분석을 통한 위암 발병 기전의 이해 및 제어기술 개발 갑상선암 환자 맞춤 진료를 위한 유전체·후성유전체 통합 진단 플랫폼 구축