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안종석 교수

Jong Seog Ahn

INFO

  • 소속캠퍼스한국생명공학연구원 스쿨
  • 전공 생명과학
    (생체분자과학)
  • 연락처043-240-6160
  • 출신전공생물공학(미생물)과
  • 학위박사
  • 최종출신대학한국과학기술원
  • 이메일

연구분야

생리활성 대사산물의 탐색과 세포 내 분자표적 규명 및 작용 기작 분석 (화학생물학)

Discovery of bioactive natural products and identification of target molecule and mechanism study in cell (Chemical Biology)

대표연구실적

-  Jae-Hyuk Jang, Yukihiro Asami, Jun-Pil Jang, Sun-Ok Kim, Dong Oh Moon, Kee-Sun Shin, Daisuke Hashizume, Makoto Muroi, Tamio Saito, Hyuncheol Oh, Bo Yeon Kim, Hiroyuki Osada and Jong Seog Ahn. Fusarisetin A, an acinar morphogenesis inhibitor from a soli fungus, Fusarium sp. FN080326. J. Am. Chem. Soc.(2011) 133: 6865-6867. -  Jun-Pil Jang, Jae-Hyuk Jang, Nak-Kyun Soung, Hye-Min Kim ,Sook-Jung Jeong, Yukihiro Asami, Kee-Sun Shin, Mee Ree Kim, Hyuncheol Oh, Bo Yeon Kim and Jong Seog Ahn. Benzomalvin E, an Indoleamine 2,3-dioxygenase Inhibitor Isolated from Penicilliumsp. FN070315.(2012) J. Antibiotics, 65(4): 215-217. -  Long He, Junwon Lee, Jae Hyuk Jang, Krisada Sakchaisri, Joonsung Hwang, Kyung A Kim, In Ja Ryoo, Sun Ok Kim, Nak Kyun Soung, Bo Yeon Kim, Jong Seog Ahn. Osteoporosis regulation by salubrinal through eIF2α mediated differentiation of osteoclast and osteoblast. (2013) Cell. Signal. 25(2): 552-560.

논문(최근 5년)

-  Gordonibacter faecihominis sp. nov. isolated from human faeces[Antonie van Leeuwenhoek,2014-09-12] -  Preclinical evlauation of bortezomib/dipyridamole novel combination as a potential therapeutic medality for hematologic malignancies[ MOLECULAR ONCOLOGY,2015-02-02] -  Induction of G1 arrest by SB265610 involves cyclin D3 down-regulation and suppression of CDK2(Thr160) phospholyation[ ANTICANCER RESEARCH,2015-03-31] -  A new enzyme inveoved in the control of the stereochemistry in the dedalin formation durign equisetin biosynthesis[ BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2015-06-01] -  Synthesis and antitumor activity of natural compound aloe emodin derivatives[Chemical Biology and Drug Design,2015-05-04] -  Eupafolin suppresses prostate cancer by targeting phophatidylinositol 3-kinase-mediated Akt signaling[ MOLECULAR CARCINOGENESIS,2015-06-10] -  Amino-terminal arginylation targets endoplasmic reticulum chaperone BiP for autophagy through p62 binding[ NATURE CELL BIOLOGY,2015-07-01] -  Pendioxolanes A and , 1,3-dioxolane cotaining azaphilone dervatives from marine-derived Penicillium sp. KCB12C078[Natural Product Sciences,2015-04-30] -  Haenamindole, an unsual deketopiperazine dervative from a marine-derived Penicillium sp. KCB12F005[ BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2015-08-03] -  Gartanin induces autophagy through JNK activation which extenuates caspase-dependent apoptosis[ ONCOLOGY REPORTS,2015-07-01] -  Inhibitory Effects of Verrucarin A on Tunicamycin-Induced ER Stress in FaO Rat Liver Cells[ MOLECULES,2015-05-19] -  Ulleungamides A and B, modified a,b-deheroipecolic acid containing cyclic depsipetides from Streptomyces sp. KCB13F003[ ORGANIC LETTERS,2015-08-11] -  Cycloexpansamines A and B: spiroindolinone alkaloids from a marine isolated of Pencillium sp. (SF-5292)[ JOURNAL OF ANTIBIOTICS,2015-10-30] -  RK-270A-C, new oxidnole derivatives isolated from a microbial metabolites frction library of Streptomyces sp. RK85-270[ JOURNAL OF ANTIBIOTICS,2015-09-30] -  A pectate lyase-coding gene abudantly expressed during early stages of infection is required for full virulence in Alternaria brassicicola[ PLOS ONE,2015-05-21] -  New neo-lignan from Achanthopanax senticosus with protein tyrosine phosphatase inhibitory activity[ ARCHIVES OF PHARMACAL RESEARCH,2015-09-15] -  Artificial de nove biosynthesis of hedroxysyrene dervatives in a tyrosine overproducing Escherichia coli strain[ MICROBIAL CELL FACTORIES,2015-10-29] -  neo-Clerodan diterpenoids from Scutellaria barbata and their inhibitory effects on LPS-induced nitric oxide production[ JOURNAL OF NATURAL PRODUCTS,2015-09-02] -  Stachybotrysin, an osteoclast differentiation inhibitor fro the mrin-derived fungus Stachybotrys sp. KCB13F013[ JOURNAL OF NATURAL PRODUCTS,2016-10-11] -  Ginsenoside Re inhibits osteoclast fifferentiation in mousbone marrow-derived macrophages and zebrafish scale model[ MOLECULES AND CELLS,2016-12-22] -  Structures and biological activities of azaphilones produced by Penicillium sp. KCB11A109 from a gindeng field[ PHYTOCHEMISTRY,2016-02-01] -  New cyclic lipopetide of the Iturin class produced by saltern-derived Bacillus sp. KCB14S06[ MARINE DRUGS,2016-04-02] -  inhibitory effets of alternaramide on inflammatory mediator expression through TRL-4MyD88-mediated inhibition of NF-kB and MAPK pathway signaling in lipopolysacchride-stimulated RAW264.7 and BV2 cells[ CHEMICO-BIOLOGICAL INTERACTIONS,2016-05-04] -  Anti-neuroinflammatory effects of citreohybridonol involving TRL4-MyD88-mediated inhibition of NF-kB nd MAPK signaling pahthways in lipopolysaccharide-stimulated BV2 cells[ NEUROCHEMISTRY INTERNATIONAL,2016-01-07] -  Anticancer activtity of a novel small molecule tubulin inhibitors STK899704[ PLOS ONE,2017-05-15] -  Polyketides and anthranilic acid posessing 6-deoxy-a-L-talopyranose from a Streptomyces speicies[ JOURNAL OF NATURAL PRODUCTS,2017-04-13] -  The fungal metabolite brefeldin A inhibits Dvl2-Plk1-dependent primary cilium disassembly[ MOLECULES AND CELLS,2017-06-30] -  Two cyclic hexapeptides from Penicillium sp. FN070315 with antiangiogenic activities[ PLOS ONE,2017-09-26] -  Octaminomycins A and B, cyclic octadepsipeptides active against Plasmodium falciparum[ JOURNAL OF NATURAL PRODUCTS,2017-01-25] -  RK-144171, a new benadrostin derivative produced by Streptomyces sp. RK88-1441[ JOURNAL OF ANTIBIOTICS,2017-02-27] -  Four new neoliganans isolated from Eleutherococcus senticosus and their protein tyrosine phophatase 1B (PTP1B) inhibitory activity [ FITOTERAPIA,2017-07-01] -  Identification of new geldanamycin derivatives from unexplored microbial culture extracts using a MS/MS library[ JOURNAL OF ANTIBIOTICS,2017-09-01]

특허(최근 5년)

-  Compositon fro prevention or treatment of cancer comprising-methlylenenaphtho2,1-B furan-2-carbohydrazine derivatives as an active ingredient[2016-09-06] -  Tubulin polymerization inhibitor and method fro synthesizing same[2017-05-09] -  신규한 고리형 뎁시펩타이드계 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 항균용 약학적 조성물[2016-10-26] -  페닐유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 세포증식성 질병의 예방 또는 치료용 약학적 조성물[2017-03-24] -  필라그린 유전자 돌연변이 검출용 프로브, 키트 및 방법[2016-06-24] -  해양진균에서 분리한 페니실리놀라이드 A를 유효성분으로 함유하는 염즈엉 질환 예방 및 치료용 조성물[2016-05-06] -  신규 튜불린 중합 저해제 및 그 합성방법[2016-01-06] -  신규 fusarisetin 화합물 및 이의 용도[2016-06-22] -  N-메틸렌나트로(2,1-ㅠ)퓨란-2카보하이드라라지드 유도체를 유효성분으로 포함하는 암 예방[2015-10-28] -  신규한 이모딘 유도체 또는 이의 약학적으로 허용 가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 암질환 예방 또는 치료용 약학적 조성물[2015-01-13] -  Fusarisetin compounds, and use theirof[2014-12-23] -  신규한 푸사리세틴 화합물 및 이의 용도[2015-04-10] -  신규한 프로투복세핀 A, B 및 프로투보닌 A 화합물 및 이를 함유하는 암 예방 또는 치료용 약학적 조성물[2014-09-18] -  수련뿌리 추출물, 이의 분획물 또는 이로부터 분리된 폴리페놀계 화합물을 유효성분으로 함유하는 대사성 질환 예방 및 치료용 약학적 조성물[2014-11-11] -  바실러스 섭틸러스 IN-55, 락토바실러스 플란타룸 BT-77 및 이를 이용한 사일리지 제조방법[2014-03-20]

연구과제 수행 실적

미생물 유래 생리활성 대사산물 개발 항암 표적단백질 및 항암 선도물질 발굴