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한동초 교수

Han, Dong Cho

INFO

  • 소속캠퍼스한국생명공학연구원 스쿨
  • 전공 생명과학
    (생체분자과학)
  • 연락처042-860-4568
  • 출신전공미생물학
  • 학위박사
  • 최종출신대학Cornell University
  • 이메일

연구분야

암세포 전이, 암줄기세포, 스트레스 제어기전 및 항암활성 화합물 발굴

Cancer metastasis, Cancer stem cell, Stress signaling, and Identification of anti-cancer chemicals

대표연구실적

-  1. KRIBB11 inhibits HSP70 synthesis through inhibition of heat shock factor 1 function by impairing the recruitment of positive transcription elongation factor b to the hsp70 promoter. J. Biol. Chem. (2011) 286(3):1737-1747 -  1. Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells. Cancer Res. (2009) 69(1):193-202. -  1. Blocking tumor cell migration and invasion with biphenyl isoxazole derivative KRIBB3, a synthetic molecule that inhibits Hsp27 phosphorylation. J. Biol. Chem. (2005) 280(50):41439-41448

논문(최근 5년)

-  Inhibition of STAT3 activation by KT-18618 via the disruption of the interaction between JAK3 and STAT3.[Biochem Pharmacol,2014-05-01] -  Ginkgetin inhibits the growth of DU-145 prostate cancer cells through inhibition of signal transducer and activator of transcription 3 activity.[Cancer Sci,2015-04-01] -  Artocarpus altilis (Parkinson) Fosberg Extracts and Geranyl Dihydrochalcone Inhibit STAT3 Activity in Prostate Cancer DU145 Cells.[Phytother Res,2015-05-01] -  Fisetin a dietary flavonoid induces apoptosis of cancer cells by inhibiting HSF1 activity through blocking its binding to the hsp70 promoter.[Carcinogenesis,2015-06-01] -  Sugiol inhibits STAT3 activity via regulation of transketolase and ROS-mediated ERK activation in DU145 prostate carcinoma cells.[Biochem Pharmacol,2015-09-01] -  Cinnamaldehyde in cancer chemotherapy[PHYTOTHERAPY RESEARCH,2016-05-01] -  PPARgamma agonists induce adipocyte differentiation by modulating the expression of Lipin-1, which acts as a PPARgamma phosphatase[INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY,2016-10-01] -  Geranylnaringenin (CG902) inhibits constitutive and inducible STAT3 activation through the activation of SHP-2 tyrosine phosphatase[BIOCHEMICAL PHARMACOLOGY,2017-06-01] -  Ginkgetin induces G2-phase arrest in HCT116 colon cancer cells through the modulation og b-Myb and microRNA34a expression[INTERNATIONAL JOURNAL OF ONCOLOGY,2017-10-01] -  Methyllucidone inhibits STAT3 activity by regulating the expression of the protein tyrosine phosphatase MEG2 in DU145 prostate carcinoma cells[BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2018-02-01] -  KRIBB53 Binds to OCT4 and Enhances Its Degradation through the Proteasome, Causing Apoptotic Cell Death of OCT4-Positive Testicular Germ Cell Tumors[CARCINOGENESIS,2018-04-01]

특허(최근 5년)

-  벤조일옥시신남알데하이드-폴리에틸렌글리콜 결합 마이셀에 아연프로토포르피린을 담지한 pH 감응형 항암전구물질[2015-09-01] -  콜포신 다로페이트를 포함하는 골 질환의 예방 또는 치료용 조성물[2015-03-18]