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김남순 교수

Kim Nam Soon

INFO

  • 소속캠퍼스한국생명공학연구원 스쿨
  • 전공 생명과학
    (기능유전체학)
  • 연락처042-879-8112
  • 출신전공기능유전체학
  • 학위박사
  • 최종출신대학University of Tokyo
  • 이메일

연구분야

암 관련 신규 타겟 발굴, 암 발병기전 규명 및 항암 맞춤치료제 개발

Functional studies of novel targets related to cancer metastasis/tumorigenesis and development of anti-cancer drug

대표연구실적

-  Inhibition of MKK7/JNK by the TOR Signaling Pathway Regulator-Like Protein Contributes to Resistance of HCC cells to TRAIL- Induced Apoptosis. /Gastroenterology/2012 -  Human ZNF312b oncogene is regulated by Sp1 binding to its promoter region through DNA demethylation and histone acetylation in gastric cancer./International Journal of Cancer/2011 -  Tussilago farfara L. augments TRAIL-induced apoptosis through MKK7/JNK activation by inhibition of MKK7-TIPRL in human hepatocellular carcinoma cells/ONCOLOGY REPORTS /2014

논문(최근 5년)

-  Direct regulation of E-cadherin by targeted histone methylation of TALE-SET fusion protein in cancer cells[Oncotarget,2015-09-15] -  IFT46 plays an essential role in cilia development[DEVELOPMENTAL BIOLOGY,2015-03-15] -  Targeting KRAS oncogene in colon cancer cells with 7-carboxylate indolo[32-b]quinoline tri-alkylamine derivatives[PLOS ONE,2015-05-29] -  KRAS oncogene repression in colon cancer cell lines by G-quadruplex binding indolo[32-c]quinolines[SCIENTIFIC REPORTS,2015-04-08] -  Novel TRAIL Sensitizer Taraxacum Officinale F.H. Wigg Enhances TRAIL-Induced Apoptosis in Huh7 Cells[MOLECULAR CARCINOGENESIS,2016-04-01] -  Tussilago farfara L. augments TRAIL-induced apoptosis through MKK7/JNK activation by inhibition of MKK7-TIPRL in human hepatocellular carcinoma cells[ONCOLOGY REPORTS,2014-09-01] -  Cell Spheroids with Enhanced Aggressiveness to Mimic Human Liver Cancer In Vitro and In Vivo[SCIENTIFIC REPORTS,2017-09-05] -  Copine1 regulates neural stem cell functions during brain development[BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2017-10-31] -  Autosomal dominant transmission of complicated hereditary spastic paraplegia due to a dominant negative mutation of KIF1A, SPG30 gene[SCIENTIFIC REPORTS,2017-10-02] -  Ottogi Inhibits Wnt-catenin Signaling by Regulating Cell Membrane Trafficking of Frizzled8[SCIENTIFIC REPORTS,2017-10-16] -  A Liver-Specific Gene Expression Panel Predicts the Differentiation Status of In Vitro Hepatocyte Models[HEPATOLOGY,2017-11-01] -  Novel indazole-based small compounds enhance TRAIL-induced apoptosis by inhibiting the MKK7-TIPRL interaction in hepatocellular carcinoma[Oncotarget,2017-11-03] -  Plasma glutamate carboxypeptidase is a negative regulator in liver cancer metastasis[ONCOTARGETS AND THERAPY,2016-11-29] -  E2-EPF UCP Possesses E3 Ubiquitin Ligase Activity via Its Cysteine 118 Residue[PLOS ONE,2016-09-29] -  Elasticity-based development of functionally enhanced multicellular 3D liver encapsulated in hybrid hydrogel[ACTA BIOMATERIALIA,2017-12-01]

특허(최근 5년)

-  TRAIL 센서타이저 타겟 유전자인 TIP41의 발현 또는 활성 억제제를 함유하는 암 예방 및 치료용 조성물[2014-04-22] -  TRAIL 센서타이저 타겟 유전자인 TIP41의 발현 또는 활성억제제를 함유하는 암예방 및 치료용 조성물[2014-05-30] -  TRAIL 센서타이저 타겟 유전자인 TIP41의 발현 또는 활성 억제제를 함유하는 TRAIL 민감성 증진용 조성물[2014-04-22] -  TRAIL 센서타이저 타겟 유전자인 TIP41의 발현 또는 활성 억제제를 함유하는 TRAIL 감수성 증진용 조성물[2014-03-27] -  울산 도깨비 바늘 추출물 및 trail을 유효성분으로 함유하는 암 예방 및 치료용 약학적 조성물[2015-12-31] -  브라질산 허브 및 trail을 유효성분으로 함유하는 암 예방 및 치료용 약학적 조성물[2015-12-31]

연구과제 수행 실적

인간 전장유전자클론 고품질화 및 분양 시스템 구축 한국인 희귀난치성 발달장애 유전체 맞춤의료 원천기술개발 희귀난치성희귀난치성 신경계질환 정밀의료 기술개발