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우의전 교수

Eui-Jeon Woo

INFO

  • 소속캠퍼스한국생명공학연구원 스쿨
  • 전공 생명과학
    (단백체구조생물학)
  • 연락처042-879-8432
  • 출신전공구조생물학
  • 학위박사
  • 최종출신대학University of Reading
  • 이메일

연구분야

구조생물학, 단백질 생화학, 효소공학

structural biology, protein biochemistry, protein engineering

대표연구실적

-  Jung TY, An Y, Park KH, Lee MH, Oh BH, Woo E / Crystal structure of the Csm1 Subunit of the Csm Complex and Its Single-Stranded DNA-Specific Nuclease Activity. Structure / 2015. March -  Chembazhi UV, Patil VV, Sah S, Reeve W, Tiwari RP, Woo E, Varshney U. / Uracil DNA glycosylase activities in B.diazoefficiens: characterization of a new class of UDG with broad substrate specificity / Nucleic Acid Research / 2017. Apr -  Park KH, An Y, Jung TY, Baek IY, Ahn WC, Hebert H, Song JJ, Kim JH, Oh BH, Woo EJ / RNA activation-independent DNA targeting by a Csm complex of the Type III CRISPR-Cas system / EMBO Report / 2017. May

논문(최근 5년)

-  Molecular cloning and functional characterization of an endo-b-13-glucanase from Streptomyces matensis ATCC23935[FOOD CHEM,2014-03-01] -  Association of bi-functional activity in the N-terminal domain of glycogen debranching enzyme[BIOCHEM BIOPHYS RES COMMUN,2014-06-01] -  Directed evolution of human chain variable domain (VH) using in vivo protein fitness filter[PLoS One,2014-06-01] -  Structural features underlying the selective cleavage of a novel exo-type maltose-forming amylase from Pyrococcus sp. ST04[ACTA CRYSTALLOGR D,2014-03-01] -  Purification and characterization of Fab fragments with rapid reaction kinetics against myoglobin.[Bioscience Biotechnology Biochemistry,2015-01-03] -  Construction of an anti-myoglobin single-chain variable fragment with rapid reaction kinetics.[Biotechnology Applied Biochemistry,2015-01-20] -  Crystal structure of the Csm1 Subunit of the Csm complex and its single-stranded DNA-specific nuclease activity.[Structure,2015-03-03] -  Crystal structure of the fungal nitroreductase Frm2 from Saccahromyces cerevisiae.[ PROTEIN SCIENCE,2015-07-01] -  A unique uracil-DNA binding protein of the uracil DNA glycosylase superfamily[ NUCLEIC ACIDS RESEARCH,2015-09-30] -  Structural Analysis of the Phenol-Responsive Sensory Domain of the Transcription Activator PoxR.[ STRUCTURE,2016-05-06] -  Structural features of Cas2 from Thermococcus onnurineus in Crispr-Cas system type IV[ PROTEIN SCIENCE,2016-10-25] -  In vivo high-throughput profiling of CRISPR-Cpf1 activity[ NATURE METHODS,2017-02-01] -  RNA activation-independent DNA targeting by a Csm complex of the Type III CRISPR-Cas system[ EMBO REPORTS,2017-05-01] -  Data of self-made Tag DNA polymerase prepared for screening purposes.[Data in Brief,2017-03-01] -  Uracil DNA glycosylase (UDG) activities in Bradyrhizobium diazoefficiens: characterization of a new class of UDG with broad substrate specificity.[ NUCLEIC ACIDS RESEARCH,2017-03-28] -  Efficient Transcriptional Gene Repression by Type I-A Crispr-Cpf1 from Eubacterium eligens [ ACS SYNTHETIC BIOLOGY,2017-04-11]

특허(최근 5년)

-  세포사멸 핵산분해효소인 엔도뉴클레아제 G 단백질의 결정 구조 및 이의 결정화 방법[2014-05-01] -  나노입자 융합된 FRET 센서 및 이를 이용한 파이토에스트로겐을 고감도로 검출하는 방법[2016-06-13]

연구과제 수행 실적

Crispr-Cas 시스템을 이용한 저산소 감지 유전자 스위치 개발 질환표적의 구조 기반 기능제어 기술 개발