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이상철 교수

Lee, Sang Chul

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  • 소속캠퍼스한국생명공학연구원 스쿨
  • 전공 생명과학
    (기능유전체학)
  • 연락처042-860-4142
  • 출신전공생화학
  • 학위박사
  • 최종출신대학연세대학교
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개인홈페이지

연구분야

줄기세포분화, 세포기능조절, 단백체학

Stem cell, Cell metabolism, Proteomics

대표연구실적

-  Investigation of adipocyte proteome during the differentiation of brown preadipocytes/JOURNAL OF PROTEOMICS/2013 -  Acetylation of malate dehydrogenase 1 promotes adipogenic differentiation via activating its enzymatic activity/JOURNAL OF LIPID RESEARCH/2012 -  RPTPu tyrosine phopshatase promotes adipogenic differentiation via modultion of p120 catenin phosphoryltion/MOLECULAR BIOLOGY OF THE CELL/2011

논문(최근 5년)

-  Selection of aptamers for mature white adipocytes by cell SELEX using flow cytometry[PLOS ONE,2014-05-20] -  Proteomic analysis of the effect of retinoic acids on the human breast cancer cell line MCF-7[MOLECULAR BIOLOGY REPORTS,2014-05-01] -  Monitoring the differentiation and migration patterns of neural cells derived from human embryonic stem cells using a microfluidic culture system[ MOLECULES AND CELLS,2014-06-01] -  Identification of lactoferrin as a human dedifferentiation factor through the studies of reptile tissue regeneration mechanisms[ JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY,2014-06-01] -  Identification of NDA aptamers toward epithelial cell adhesion molecule via cell-SELEX[ MOLECULES AND CELLS,2014-10-01] -  Stimulation of angiogenesis and survival of endothelial cells by human monoclonal Tie2 receptor antibody[ BIOMATERIALS,2015-06-01] -  Recent advances in proteomic studies of adpose tissues an adipocytes[ INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2015-02-27] -  Intracellular annexin A2 regulates NF-Kappa B signaling by binding to the p50 subunit : implications for gemcitabine resistance in pancreatic cancer[CELL DEATH & DISEASE,2015-07-01] -  Extension of in vivo half-life of endostatin and its improved anti-tumor activities upon fusion to a humanized antibody against tumor-associated glycoprotein 72 in a mouse model of human colorectal carcinoma[ ONCOTARGET,2015-01-22] -  DUSP4 regulates neuronal differentiation an calcium homeostasis by modulating ERK1/2 phosphorylation [ STEM CELLS AND DEVELOPMENT,2015-03-01] -  Gecko proteins induce the apoptosis of bladder cancer 5637 cells by inhibiting Akt and activating the intrinsic caspase cascade[BMB REPORTS,2015-09-01] -  Silica nanoparticles inhibit brown adipocyte differentiation via regulation of p38 phosphorylation[NANOTECHNOLOGY,2015-10-01] -  Phosphoprotein phosphatase 1CB (PPP1CB), a novel adipogenic activator, promotes 3T3-L1 adipogenesis[ BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2015-11-01] -  MAP kinase phophatase 3 inhibit brown adipocyte differentiaon via regulation of ErK phosphorylation[ MOLECULAR AND CELLULAR ENDOCRINOLOGY,2015-11-01] -  Loss of NDRG2 promotes epithelial-mesenchymal transition of gallbladder carcinoma cells through MMP-19-mediated Slug expression[ JOURNAL OF HEPATOLOGY,2015-12-01] -  Profiling analysis of protein tyrosine phosphatases during neuronal differentiation [ NEUROSCIENCE LETTERS,2016-01-01] -  C-Jun regulates adipocyte differentiation via the KLF15-mediated mode[ BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2016-01-01] -  Methyltransferase and demeththylase profiling studies during brown adipocyte differentiation[ BMB REPORTS,2016-07-01] -  Set7/9, a methyltransferase, regulates the thermogenic program during brown adipocyte differentiation through the modulation of p53 acetylation[ MOLECULAR AND CELLULAR ENDOCRINOLOGY,2016-04-29] -  Crucial role of HMGA1 in the self-renewal and during resistance of ovarian cancer sten cells[EXPERIMENTAL AND MOLECULAR MEDICINE,2016-08-26] -  High-resolution crystal structure of the PDZ1 domain of human protein tyrosine phosphatase PTP-Bas[ BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2016-08-18] -  Structural insight into the critical role of the N-terminal region in the catalytic activiy of dual-specificity[PLOS ONE,2016-09-01] -  Graphene oxide induces apoptotic cell death in endothelial cells by activating autophagy via calcium-dependent phosphorylation of c-Jun N-terminal kinases [ACTA BIOMATERIALIA,2016-09-15] -  Metabolic adaptation in obesity and type II diabetes : Myokines, adipokines and hepatokines [ INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2017-01-01] -  N-acteylated proline-glycine-proline accelerates cutaneous wound healing and neovascularization by human endothelial progenitor cells[ SCIENTIFIC REPORTS,2017-02-23]

특허(최근 5년)

-  MDH1의 아세틸화 억제제를 이용한 항비만용 조성물[2015-08-06] -  PTP-RE를 이용한 갈색 지방세포 분화 조절 방법[2015-11-20] -  성숙백색지방세포에 특이적으로 결합하는 핵산 앱타머 및 이의 용도[2015-09-01] -  성숙백색지방세포에 특이적으로 결합하는 핵산 앱타머 및 이의 용도[2015-08-11] -  EpCAM에 특이적으로 결합하는 핵산 앱타머 및 이의 용도[2016-07-18] -  코플린-1을 이용한 갈색 지방세포 분화 조절 방법[2016-09-27] -  신규한 신경세포 마커 및 이의 용도[2016-09-28]