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고정헌 교수

Ko Jeong Heon

INFO

  • 소속캠퍼스한국생명공학연구원 스쿨
  • 전공 생명과학
    (생체분자과학)
  • 연락처042-860-4133
  • 출신전공생화학
  • 학위박사
  • 최종출신대학연세대학교
  • 이메일

연구분야

당생물학 측면에서의 암바이오마커 개발

Cancer biomarkers development with glycobiological approach

대표연구실적

-  Ju Hee Lee, Chang Hee Cho, Sun Hee Kim, Jeong Gu Kang, Jong Shin Yoo, Chulhun Ludgerus Chang, Jeong-Heon Ko*, and Yong-Sam Kim* "Semi-quantitative Measurement of a Specific Glycoform Using a DNA-tagged Antibody and Lectin Affinity Chromatography for Glyco-biomarker Development" Molecular and Cellular Proteomics, (2015) -  Yong-Sam Kim, Soo Young Hwang, Hye-Yeon Kang, Hosung Sohn, Sejeong Oh, Jin-Young Kim, Jong Shin Yoo, Young Hwan Kim, Cheorl-Ho Kim, Jae-Heung Jeon, Jung Mi Lee, Hyun Ah Kang, Eiji Miyosh, Naoyuki Taniguchi, Hyang-Sook Yoo, and Jeong-Heon Ko* " Functional Proteomics Study Reveals That N-Acetylglucosaminyltransferase V Reinforces the Invasive/Metastatic Potential of Colon Cancer through Aberrant Glycosylation on Tissue Inhibitor of Metalloproteinase-1" Molecular and Cellular Proteomics, (2008) -  Hosung Sohn, Yong-Sam Kim, Hyun-Taek Kim, Cheol-Hee Kim, Eun-Wie Cho, Hye-Yeon Kang, Nam-Soon Kim, Cheorl-Ho Kim, Seong Eon Ryu, Jeong-Hwa Lee and Jeong Heon Ko*"Ganglioside GM3 is involved in neuronal cell death" FASEB Journal (2006)

논문(최근 5년)

-  Differential proteomic approach for identification and verification of aberrantly glycosylated proteins in adenocarcinoma lung cancer (ADLC) plasmas by lectin-[JOURNAL OF PROTEOMICS,2014-04-26] -  Hepatitis B virus X protein specially regulates the sialyl lewis a synthesis among glycosylation events for metastasis sialyl lewis a synthesis among glycosylation events for metastasis[Molecular Cancer,2014-10-01] -  Semi-quantitative measurement of a specific glycoform using a DNA-tagged antibody and lectin affinity chromatography for glyco-biomarker development[ MOLECULAR & CELLULAR PROTEOMICS,2015-01-15] -  Direct regulation of E-cadherin by targeted histone methylation of TALE-SET fusion protein in cancer cells [Oncotarget,2015-09-15] -  ERK-mediated phosphorylation of BIS regulates nuclear translocation of HSF1 under oxidative stress[Experimental and Molecular Medicine,2016-08-15] -  Identification of mycobacterial antigens in human urine by use of immunoglobulin g isolated from sera of patients with active pulmonary tuberculosis[ JOURNAL OF CLINICAL MICROBIOLOGY,2016-06-15] -  Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis[ NATURE CELL BIOLOGY,2016-07-15] -  Application of cancer-associated glycoforms and glycan-binding probes to an in vitro diagnostic multivariate index assay for precise diagnoses of cancer[ PROTEOMICS,2016-10-15] -  Integrated GlycoProteome Analyzer (I-GPA) for automated identification and quantitation of site-specific N-glycosylation[ SCIENTIFIC REPORTS,2016-11-15] -  β1,6-GlcNAc linkage to the core glycan on TIMP-1 affects its gelatinase inhibitory activities: aberrantly glycosylated TIMP-1-MMP2 complex modeling shows weaker interaction compared to Bi-antennary glycosylated TIMP-1[Bulletin of the Korean Chemical Society,2017-01-16] -  BIS overexpression does not affect the sensitivity of HEK 293T cells against apoptosis[Molecular & Cellular Toxicology,2017-02-15] -  Lectin from Sambucus sieboldiana abrogates the anoikis resistance of colon cancer cells conferred by N-acetylglucosaminyltransferase V during hematogenous metastasis[ ONCOTARGET,2017-03-15] -  Corrigendum: Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis[ NATURE CELL BIOLOGY,2016-06-28] -  14-3-3β Depletion Drives a Senescence Program in Glioblastoma Cells Through the ERK/SKP2/p27 Pathway[ MOLECULAR NEUROBIOLOGY,2017-01-23] -  Correction for Kim et al., Identification of Mycobacterial Antigens in Human Urine by Use of Immunoglobulin G Isolated from Sera of Patients with Active Pulmonary Tuberculosis[ JOURNAL OF CLINICAL MICROBIOLOGY,2016-08-08] -  Network Structure and Function in Parkinson's Disease[ CEREBRAL CORTEX,2017-10-15]

특허(최근 5년)

-  렉틴 침전법을 이용한 당단백질의 동정 방법[2014-05-23] -  항-사이토케라틴 8/18 복합체 자가면역항체를 포함하는 암 진단 마커 및 이의 항원을 포함하는 암 진단용 조성물[2014-03-10] -  항-ATIC 자가면역항체를 포함하는 간암 진단 마커 및 이의 항원을 포함하는 간암 진단용 조성물[2014-09-03] -  표적 유전자 특이적 핵산 프로브 및 FokⅠ 제한효소 이량체를 이용하여 세포 내에서 표적 유전자를 특이적으로 편집하기 위한 조성물 및 이의 용도[2016-11-04] -  엑소좀 단백질 EIF3A 특이반응 오토항체검출용 항원 조성물 및 이를 이용한 간암진단법[2017-06-19] -  다중 당단백질의 발현량 및 당질변이의 측정을 통한 간암의 예측방법[2016-01-04] -  항-ATIC 자가면역항체를 포함하는 간암 진단 마커 및 이의 항원을 포함하는 간암 진단용 조성물[2016-08-17] -  항-사이토케라틴 8/18 복합체 자가면역항체를 포함하는 암 진단 마커 및 이의 항원을 포함하는 암 진단용 조성물[2016-02-10] -  항-사이토케라틴 8/18 복합체 자가면역항체를 포함하는 암 진단 마커 및 이의 항원을 포함하는 암 진단용 조성물[2016-01-12]