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TAE DON KIM

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  • 소속캠퍼스한국생명공학연구원 스쿨
  • 전공 생명과학
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연구분야

RNA 생물학, 면역학, 면역세포 치료제

RNA biology, Immunology, Immuno cancer therapy

대표연구실적

-  주저자: Human microRNA-27a* targets Prf1 and GzmB expression to regulate NK-cell cytotoxicity/Blood/Nov. 2011 (IF: 15.28) -  교신저자:MicroRNA-150 regulates the cytotoxicity of natural killers by targeting perforin-1/JACI/Apr. 2014 (IF: 13.28) -  교신저자: MicroRNA-150 controls differentiation of intraepithelial lymphocytes via TGF-b receptor II expression/JACI/Aug. 2017 (IF: 13.28)

논문(최근 5년)

-  MicroRNA-150 regulates the cytotoxicity of natural killers by targeting perforin-1[JACI,2014-07-12] -  An increased level of IL-6 suppresses NK cell activity in peritoneal fluid of patients with endometriosis via regulation of SHP-2 expression[Hum Reprod,2014-10-01] -  Integrated mRNA-microRNA profiling of human NK cell differentiation identifies miR-583 as a negative regulator of IL2Rγ expression[PloS One,2014-10-14] -  Understanding of molecular mechanisms in natural killer cell therapy[EXPERIMENTAL AND MOLECULAR MEDICINE,2015-02-09] -  Thioredoxin-interacting protein regulates haematopoietic stem cell ageing and rejuvenation by inhibiting p38 kinase activity[NATURE COMMUNICATIONS,2016-12-08] -  Ginsenoside Rg3 regulates S-nitrosylation of the NLRP3 inflammasome via suppression of iNOS[ BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2015-08-07] -  Heterogeneous ribonucleoprotein R regulates arylakylamine N-acetyltransferase synthesis via interal ribosomal entry site-mediated translation in a circadian manner[ JOURNAL OF PINEAL RESEARCH,2015-11-01] -  Osteoporotic bone of miR-150-deficient mice: Possibly due to low serum OPG-mediated osteoclast activation[Bone Reports,2015-06-01] -  Suppressor of Cytokine Signaling 2 Negatively Regulates NK Cell Differentiation by Inhibiting JAK2 Activity[ SCIENTIFIC REPORTS,2017-04-01] -  Heterogeneous ribonucleoprotein R regulates arylalkylamine N-acetyltransferase synthesis via internal ribosomal entry site-mediated translation in a circadian manner[ JOURNAL OF PINEAL RESEARCH,2015-11-01] -  MicroRNA-150 modulates intracellular Ca 2+levels in naive CD8+T cells by targeting TMEM20[ SCIENTIFIC REPORTS,2017-06-01] -  MicroRNA-150 controls differentiation of intraepithelial lymphocytes via TGF-b receptor II expression[ JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY,2017-08-01] -  miR-150-Mediated Foxo1 Regulation Programs CD8+ T Cell Differentiation[ CELL REPORTS,2017-09-01]

특허(최근 5년)

-  miR-150의 발현을 조절하여 자연살해세포의 세포독성을 증가시키는 방법[2016-08-12] -  세포 스페로이드 배양기를 포함하는 세포 스페로이드 배양 시스템 [2017-05-29]

연구과제 수행 실적

점막면역체계에서 microRNA의 역할에 관한 연구 줄기세포 유래 맞춤형 용복합 NK세포치료제개발