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지승욱 교수

Chi Seung-Wook

INFO

  • 소속캠퍼스한국생명공학연구원 스쿨
  • 전공 생명과학
    (단백체구조생물학)
  • 직급전공책임교수
  • 연락처042-860-4277
  • 출신전공생명과학
  • 학위박사
  • 최종출신대학한국과학기술원
  • 이메일

연구분야

단백질 구조생물학, 구조기반약물개발, 나노포어 센서 개발

Protein Structural Biology, Structure-Based Drug Development, Nanopore sensor

대표연구실적

-  Ha et al., Molecular Mimicry-Based Repositioning of Nutlin-3 to Anti-Apoptotic Bcl-2 Family Proteins. J. Am. Chem. Soc. 2011년 1월 -  Won et al., High-resolution crystal structure of the catalytic domain of human dual-specificity phosphatase 26. Acta Crystallogr. D Biol. Crystallogr. 2013년 6월 -  Ha et al., Dual-site interactions of p53 transactivation domain with anti-apoptotic Bcl-2 family proteins reveal a highly convergent mechanism of divergent p53 pathways. J. Biol. Chem. 2013년 1월

논문(최근 5년)

-  A conserved mechanism for binding of p53 DNA-binding domain and anti-apoptotic Bcl-2 family proteins[MOLECULES AND CELLS,2014-03-14] -  Direct Binding of Bcl-2 Family Proteins by Quercetin Triggers Its Pro-Apoptotic Activity[ACS chemical biology,2014-12-19] -  HAX1 regulates E3 ubiquitin ligase activity of cIAPs by promoting their dimerization[Oncotarget,2014-10-30] -  Identification of DNA Aptamers toward Epithelial Cell Adesion Molecule via Cell-SELEX[MOLECULES AND CELLS,2014-10-31] -  Identification of a novel function of CX-4945 as a splicing regulator = CX-4945의 스플라이싱 조절기능 규명[PLOS ONE,2014-04-17] -  Identification of novel binding partners for caspase-6 using a proteomic approach[JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY,2014-09-29] -  Structural insights into the transcription-independent apoptotic pathway of p53[BMB REPORTS = J BIOCHEM MOL BIOL,2014-03-31] -  Structure and apoptotic function of p73[ BMB REPORTS,2015-02-28] -  Enhanced humanization and affinity maturation of neutralizing anti-hepatitis B virus[FEBS Letters,2015-01-16] -  Structural convergence of unstructured p53 family transactivation domains in MDM2 recognition[ CELL CYCLE,2015-01-15] -  Histone H3 is digested by Granzyme A during compromised cell death in the Raji cells[ JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY,2015-06-02] -  Ubiquitination-dependent degradation of p73 by the mitochondrial E3 ubiquitin ligase Hades[ BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2015-11-13] -  MAP kinase phosphatase 3 inhibits brown adipocyte differentiation via regulation of Erk phosphorylation[ MOLECULAR AND CELLULAR ENDOCRINOLOGY,2015-11-15] -  High-resolution crystal structure of the PDZ1 domain of human protein tyrosine phosphatase PTP-Bas[ BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2016-09-23] -  Probing the small-molecule inhibition of an anticancer therapeutic protein-protein interaction using a solid-state nanopore[ ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2016-05-04] -  Set7/9, a methltransferase, regulates the thermogenic program during brown adipocyte differentiation through the modulation of p53 acetylation[ MOLECULAR AND CELLULAR ENDOCRINOLOGY,2016-08-15] -  A chemical with proven clinical safety rescues Down-syndrome-related phenotypes in through DYRK1A inhibition[ DISEASE MODELS & MECHANISMS,2016-08-01] -  Structural insight into the critical role of the N-terminal region in the catalytic activity of Dual-Specificity Phosphatase 26[ PLOS ONE,2016-09-01] -  Histone H4 is cleaved by granzyme A during staurosporine-induced cell death in B-lymphoid Raji cells[ BMB REPORTS,2016-10-31] -  Rational design and structure-activity relationship studies of quercetin-amino acid hybrids targeting the anti-apoptotic protin Bcl-XL[ ORGANIC & BIOMOLECULAR CHEMISTRY,2017-09-07]

연구과제 수행 실적

나노스케일 및 구조 기반 MCMT 분자표적 발굴 나노이온소자 적용을 위한 단백질 기반 바이오컨텐츠 설계 및 활용 기술 개발 단백질 서열 분석을 위한 나노포어 기반 단백질 측정 연구 질환표적의 구조 기반 기능제어 기술 개발