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정초록 교수

Cho-Rok Jung

INFO

  • 소속캠퍼스한국생명공학연구원 스쿨
  • 전공 생명과학
    (기능유전체학)
  • 연락처042-860-4176
  • 출신전공병원미생물학
  • 학위박사
  • 최종출신대학부산대학교
  • 이메일

연구분야

유전자 기능분석 및 활용성 검증, 유전자 치료, 생체모사 3차원 세포 배양,

Target identification and validation, gene therapy, In vivo mmimic 3D cell culture

대표연구실적

-  CR Jung et al, E2-EPF (ubiquitin carrier protein) UCP targets pVHL for degradation and associated with tumor growth and metastasis, Nat. Med. 2006 -  CR Jung et al, Adenovirus-Mediated Transfer of siRNA against PTTG1 inhibit liver cancer growth in vitro and in vivo, Hepatology, 2006 -  CR Jung et al, Enigma negatively regulates p53 through MDM2 and promotes tumor cell survival in mice, JCI, 2010

논문(최근 5년)

-  Oncotropic H-1 parvovirus infection degrades HIF-1α protein in human pancreatic cancer cells independently of VHL and RACK1[Internation journal of oncology,2015-04-06] -  E2-EPF UCP regulates stability and functions of missense mutant pVHL via ubiquitin mediated proteolysis[BMC CANCER,2015-10-29] -  E2-EPF UCP possesses E3 ubiquitin ligase activity via its cysteine 118 residue[PLOS ONE,2016-10-07] -  Plasma glutamate carboxypeptidase is a negative regulator in liver cancer metastasis[Oncotarget,2017-03-07] -  Cell spheroids with enhanced aggressiveness to mimic human liver cancer In vitro and In vivo[SCIENTIFIC REPORTS,2017-09-08] -  Novel prognostic marker PRMT1 regulates cell growth via downregulation of CDKN1A in HCC[Oncotarget,2018-01-16] -  Novel indazole-based small compounds enhance TRAIL-induced apoptosis by inhibiting the MKK7-TIPRL interaction in hepatocellular carcinoma[Oncotarget,2018-01-02] -  Distinctive genomic signature of neural and intestinal organoids from familial Parkinson’s disease patient-derived induced pluripotent stem cells[NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY,2017-11-10] -  Transcriptome dynamics of human pluripotent stem cell-derived contracting cardiomyocytes using an embryoid body model with fetal bovine serum[MOLECULAR BIOSYSTEMS,2017-08-07] -  A liver-specific gene expression panel predicts the differentiation status of In vitro hepatocyte models[HEPATOLOGY,2017-10-27] -  Biomaterials and culture technologies for regenerative therapy of liver tissue[ADVANCED HEALTHCARE MATERIALS,2017-02-02] -  Elasticity-based development of functionally enhanced multicellular 3D liver encapsulated in hybrid hydrogel[ACTA BIOMATERIALIA,2017-11-10] -  Development of an alternative zebrafish model for drug-induced intestinal toxicity[JOURNAL OF APPLIED TOXICOLOGY,2017-12-29] -  Comparative analysis of human embryonic stem cell derived neural stem cells as an in vitro human model[INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,2017-12-29] -  EHMT2 is a metastasis regulator in breast cancer[BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2018-02-06] -  Triclosan affects axon formation in the neural development stages of zebrafish embryos (Danio rerio)[ENVIRONMENTAL POLLUTION,2018-02-09] -  In vitro and in vivo imaging and tracking of intestinal organoids from human induced pluripotent stem cells[FASEB JOURNAL,2018-01-16] -  Shikonin induces apoptosis of lung cancer cells via activation of FOXO3a/EGR1/SIRT1 signaling antagonized by p300[BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS,2016-09-05] -  MicroRNA-150 controls differentiation of intraepithelial lymphocytes through TGF-β receptor II regulation[JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY,2017-07-12]

특허(최근 5년)

-  치료적 혈관신생 방법[2015-07-16] -  이중구조의 세포배양용기[2014-07-16] -  E2EPF UCP-VHL 상호작용 및 그 용도[2015-04-15] -  E2EPF UCP-VHL 상호작용 및 그 용도[2014-04-04] -  E2EPF UCP-VHL 상호작용 및 그 용도[2015-04-15]

연구과제 수행 실적

생체모사 인공실험체(NOCS)기반 개인 맞춤질환모델 개발 지방간염/간암의 동시발생 기전 규명과 치료원천기술 개발