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손명진 교수

Myung Jin Son

INFO

  • 소속캠퍼스한국생명공학연구원 스쿨
  • 전공 생명과학
    (기능유전체학)
  • 연락처042-860-4477
  • 출신전공분자생물학
  • 학위박사
  • 최종출신대학부산대학교
  • 이메일

연구분야

줄기세포, 오가노이드

Stem cells, Organoid

대표연구실적

-  Lee HJ, Son MJ*, Ahn J, Oh SJ, Lee M, Kim A, Jeung YJ, Kim HG, Won M, Lim JH, Kim NS, Jung CR, Chung KS. Elasticity-based development of functionally enhanced multicellular 3D liver encapsulated in hybrid hydrogel. Acta Biomater, 64, 67-79, 2017 -  Son MJ, Kwon Y, Son M, Seol B, Choi H, Ryu S, Choi C, Cho YS. Mitofusins deficiency elicits mitochondrial metabolic reprogramming to pluripotency. Cell Death & Diff, 22, 1957-69, 2015 -  Son MJ, Woolard K, Nam DH, Lee J, Fine HA. SSEA-1 is an enrichment marker for tumor initiating cells in human glioblastoma. Cell Stem Cell, 4, 440-452, 2009

논문(최근 5년)

-  Biochemical and molecular characterization of novel mutations in GLB1 and NEU1 in patient cells with lysosomal storage disorders[Biochemical and Biophysical Research Communications,2015-02-02] -  Mitofusins deficiency elicits mitochondrial metabolic reprogramming to pluripotency[Cell Death Differ.,2015-04-17] -  Restoration of mitochondrial NAD+ levels delays stem cell senescence and facilitates reprogramming of aged somatic cells[STEM CELLS,2016-12-01] -  Shikonin induces apoptosis of lung cancer cells via activation of FOXO3a/EGR1/SIRT1 signaling antagonized by p300[BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH,2016-11-01] -  Up-regulation of mitochondrial NAD+ levels impairs the clonogenicity of SSEA1+ glioblastoma tumor-initiating cells[EXPERIMENTAL AND MOLECULAR MEDICINE,2017-06-09] -  Elasticity-based development of functionally enhanced multicellular 3D liver encapsulated in hybrid hydrogel[ACTA BIOMATERIALIA,2017-12-01] -  A novel and safe small molecule enhances hair follicle regeneration by facilitating metabolic reprogramming[EXPERIMENTAL AND MOLECULAR MEDICINE,2018-12-06]

연구과제 수행 실적

오가노이드 기반 당뇨 치료제 개발 생체모사 간/신장/심장 3D 모델 제작