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윤석란 교수

Yoon, Suk Ran

INFO

  • 소속캠퍼스한국생명공학연구원 스쿨
  • 전공 생명과학
    (기능유전체학)
  • 연락처042-860-4239
  • 출신전공Cell Biology
  • 학위박사
  • 최종출신대학University of Montreal
  • 이메일

연구분야

성체줄기세포 분화, 면역치료제

(adult stem cell differentiation, immunotherapy)

대표연구실적

-  An increased level of IL-6 suppresses NK cell activity in peritoneal fluid of patients with endometriosis via regulation of SHP-2 expression. Hum Reprod. 29(10):2176-89. 2014 -  Understanding of molecular mechanisms in natural killer cell therapy. Exp Mol Med. 47:e141. 2014 -  Natural Killer Cells Infused after Human Leukocyte Antigen-Haploidentical Hematopoietic Cell Transplantation: A Dose-Escalation Study. Biol Blood Marrow Transplant. pii: S1083-8791(14)00076-7. 2014

논문(최근 5년)

-  Integrated mRNA-MicroRNA Profiling of Human NK Cell Differentiation Identifies MiR-583 as a Negative Regulator of IL2Rγ Expression.[PLOSOne,2014-10-10] -  An increased level of IL-6 suppresses NK cell activity in peritoneal fluid of patients with endometriosis via regulation of SHP-2 expression.[Human Reproduction,2014-10-10] -  The EF-hand calcium-binding protein tescalcin is a potential oncotarget in colorectal cancer[Oncotarget,2014-04-30] -  Identification of lactoferrin as a human dedifferentiation factor through the studies of reptile tissue regeneration mechanisms[JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY,2014-03-13] -  Understanding of molecular mechanisms in natural killer cell therapy[Exp Mol Med.,2015-02-15] -  Ginsenoside Rg3 regulates S-nitrosylation of the NLRP3 inflammasome via suppression of iNOS.[ BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2015-08-07] -  Thioredoxin-interacting protein regulates haematopoietic stem cell ageing and rejuvenation by inhibiting p38 kinase activity.[ NATURE COMMUNICATIONS,2016-12-08] -  Donor-Derived Natural Killer Cell Infusion after Human Leukocyte Antigen-Haploidentical Hematopoietic Cell Transplantation in Patients with Refractory Acute Leukemia.[BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,2016-11-22] -  Genkwadaphnin promotes leukocyte migration by increasing CD44 expression via PKD1/NF-κB signaling pathway[ IMMUNOLOGY LETTERS,2016-05-15] -  Epigenetic modification of TLR4 promotes activation of NF-κB by regulating methyl-CpG-binding domain protein 2 and Sp1 in gastric cancer.[ ONCOTARGET,2015-12-10] -  Cystatin SN inhibits auranofin-induced cell death by autophagic induction and ROS regulation via glutathione reductase activity in colorectal cancer.[ CELL DEATH & DISEASE,2017-03-16] -  Macrophage migration inhibitory factor interacts with thioredoxin-interacting protein and induces NF-κB activity.[ CELLULAR SIGNALLING,2017-06-15] -  Suppressor of Cytokine Signaling 2 Negatively Regulates NK Cell Differentiation by Inhibiting JAK2 Activity.[ SCIENTIFIC REPORTS,2017-04-06] -  Opa-interacting protein 5 modulates docetaxel-induced cell death via regulation of mitophagy in gastric cancer.[Tumor Biology,2017-10-10] -  Ginsenoside Rg3 ameliorated HFD-induced hepatic steatosis through downregulation of STAT5-PPARγ.[ JOURNAL OF ENDOCRINOLOGY,2017-12-10] -  MicroRNA-150 modulates intracellular Ca2+ levels in naive CD8+ T cells by targeting TMEM20[ SCIENTIFIC REPORTS,2017-06-01] -  Cystatin SN inhibits auranofin-induced cell death by autophagic induction and ROS regulation via glutathione reductase activity in colorectal cancer[ CELL DEATH & DISEASE,2017-09-14] -  Protein phosphatase 1B dephosphorylates Rho guanine nucleotide dissociation inhibitor 1 and suppresses cancer cell migration and invasion[CANCER LETTERS,2018-03-01] -  MicroRNA-150 controls differentiation of intraepithelial lymphocytes through TGF-β receptor II regulation[JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY,2018-08-01] -  TLR4/NF-κB axis induces fludarabine resistance by suppressing TXNIP expression in acute myeloid leukemia cells[BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2018-10-15] -  TXNIP regulates AKT-mediated cellular senescence by direct interaction under glucose-mediated metabolic stress.[AGING CELL,2018-08-31] -  Prostaglandin E2 secreted by thyroid cancer cells contributes to immune escape through the suppression of natural killer (NK) cell cytotoxicity and NK cell differentiation[FRONTIERS IN IMMUNOLOGY,2018-08-09]

특허(최근 5년)

-  제대혈 CD14 양성 단핵세포로부터 자연살해세포 분화 및 증식 방법[2014-09-29]

연구과제 수행 실적

마우스모델을 이용한 남성 난임 개선 치료제 개발 줄기세포유래 맞춤형 융복합NK 세포치료제 개발 해양 미생물 면역체계 CRISPR/Cas 시스템을 이용한 신규 면역 조절 물질의 생산과 활용 마우스모델을 이용한 남성 난임 개선 유효약재 발굴 남성 난임에 대한 보신오자탕의 비임상 효능연구 해양미생물 면역체계 CRISPR/Cas 시스테을 이용한 신규면역조절 물질 생산과 활용 미래형 유전자 편집 항암면역치료제 개발