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김선홍 교수

SUNHONG KIM

INFO

  • 소속캠퍼스한국생명공학연구원 스쿨
  • 전공 생명과학
    (생체분자과학)
  • 연락처042-860-4278
  • 출신전공생명과학
  • 학위박사
  • 최종출신대학한국과학기술원
  • 이메일
개인홈페이지

연구분야

분자세포생물학, 세포신호전달, 분자유전학, 신약개발

Molecular Cell biology, cell signal transduction, molecular genetics, drug discovery

대표연구실적

-  1. Cha, G.H.*, Kim, S.*, Park, J.*, Lee, E., Kim, M., Lee, S. B., Kim, J. M., Chung, J., and Cho, K. S. (2005) Parkin negatively regulates JNK pathway in the dopaminergic neurons of Drosophila. Proc. Natl. Acad. Sci. U S A. 102(29):10345-10350. (*: co-first author) (IF: 9.681, citation: 119) -  2. Lee, S. B.*, Kim, S.*., Lee, J., Park, J., Lee, G., Kim, Y., Kim, J. M., and Chung, J. (2007) Atg1, an autophagy regulator, inhibits cell growth by negatively regulating p70 S6 kinase. EMBO Rep. 8(4):360-365. (*: co-first author) (IF: 7.355, citation: 92) -  3. Kim, S.*, Kim, Y.*, Lee, J., and Chung, J. (2010) Regulation of FOXO1 by TAK1-Nemo-like kinase pathway. J. Biol. Chem. 285(11): 8122-8129. (*: co-first author) (IF:4.773, citation: 13)

논문(최근 5년)

-  Perspectives on the therapeutic potential of short-chain fatty acid receptors[BMB reports,2014-03-03] -  Identification of novel binding partners for caspase-6 using a proteomic approach[JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY,2014-05-01] -  Regulation of diacylglycerol acyltransferase 2 protein stability by gp78-associated endoplasmic-reticulum-associated degradation[FEBS JOURNAL,2014-07-01] -  Discovery of a novel class of diacylglycerol acyltransferase 2 inhibitors with a 1H-Pyrrolo[23-b]pyridine core[BIOLOGICAL & PHARMACEUTICAL BULLETIN,2014-08-07] -  HAX1 regulates E3 ubiquitin ligase activity of cIAPs by promoting their dimerization.[ONCOTARGET,2014-09-29] -  Synergistic effect of two E2 ubiquitin conjugating enzymes in SCF(hFBH1) catalyzed polyubiquitination[BMB REPORTS,2015-01-01] -  The GATA factor elt-1 regulates C.elegans developmental timing by promoting expression of the let-7 family microRNAs[ PLOS GENETICS,2015-03-27] -  Histone H3 is digested by granzyme A during compromised cell death in the raji cells[JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY,2015-09-01] -  Selective novel inverse agonists for human GPR43 augment GLP-1 secretion[ EUROPEAN JOURNAL OF PHARMACOLOGY,2016-01-31] -  Histone H4 is cleaved by granzyme A during staurosporine-induced cell death in B-lymphoid Raji cells[BMB REPORTS,2016-10-01] -  cIAPs promote the proteasomal degradation of mutant SOD1 linked to familial amyotrophic lateral sclerosis[ BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2016-11-18] -  Epigenetic changes in neurodegenerative diseases[MOLECULES AND CELLS,2016-11-30] -  The cellular basis of dendrite pathology in neurodegenerative diseases[BMB REPORTS,2017-01-01] -  The p90 ribosomal S6 kinase-UBR5 pathway controls toll-like receptor signaling via miRNA-induced translational inhibition of TNF receptor?associated factor 3[JOURNAL OF BIOLOGICAL CHEMISTRY,2017-05-30] -  Chromatin changes associated with neuronal maintenance and their pharmacological application[ CURRENT NEUROPHARMACOLOGY,2018-02-01] -  An efficient synthetic protocol for amide derivatives of Boc-2-aminoisobutyrate[ARCHIVES OF PHARMACAL RESEARCH,2018-02-24] -  Recent Advances in Studies on the Therapeutic Potential of Dietary Carotenoids in Neurodegenerative Diseases[OXIDATIVE MEDICINE AND CELLULAR LONGEVITY,2018-04-16] -  Facile ring opening reaction of oxazolone enables efficient amidation for aminoisobutyric acid [ARCHIVES OF PHARMACAL RESEARCH,2018-04-25]

특허(최근 5년)

-  신규한 디아실글리세롤 아실트랜스퍼레이즈 2 억제물질 및 이의 이용[2014-11-17] -  GPR43의 활성평가법[2015-05-26] -  SRF-RE루시퍼라아제를 이용한 LGR5의 활성평가법[2015-08-27] -  디아실글리세롤 아실트랜스퍼레이즈 억제용 신규 아자인돌계 화합물 및 이의 이용[2016-02-15] -  GPR43의 활성평가법[2017-01-20] -  2-옥소-1,2,3,4-테트라하이로피리미딘-5-카르복사미드유도체를 유효성분으로 함유하는 대사성 질환 예방 또는 치료용 약학적 [2016-09-08] -  GPR43 의 활성평가법[2018-01-23] -  HAX1 억제제를 유효성분으로 포함하는 염증성 질환 예방 또는 치료용 약학적 조성물 및 이를 이용한 스크리닝 방법[2017-05-08]