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이규선 교수

Kyu-Sun Lee

INFO

  • 소속캠퍼스한국생명공학연구원 스쿨
  • 전공 생명과학
    (기능유전체학)
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  • 학위박사
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연구분야

성인만성질환 치료 기술 개발

Develop therapeutics for age-related diseases

대표연구실적

-  이규선외/Polo Kinase Phosphorylates Miro to Control ER-Mitochondria Contact Sites and Mitochondrial Ca(2+) Homeostasis in Neural Stem Cell Development/Developmental Cell/2016.08 -  이규선외/Roles of PINK1, mTORC2, and mitochondria in preserving brain tumor-forming stem cells in a noncanonical Notch signaling pathway/Genes&Development/2013.12 -  이규선외/Drosophila short neuropeptide F signalling regulates growth by ERK-mediated insulin signalling/NatureCellBiology/2008.04

논문(최근 5년)

-  Targeting PINK1 and MQC in brain tumors[ONCOTARGET,2014-05-30] -  The myriad roles of Miro in the nervous system: axonal transport of mitochondria and beyond[FRONTIERS IN CELLULAR NEUROSCIENCE,2014-10-28] -  Curcumin mitigates accelerated aging after irradiation in Drosophila by reducing oxidative stress[BIOMED RESEARCH INTERNATIONAL,2015-03-15] -  Genome-wide microRNA screening reveals that the evolutionary conserved miR-9a regulates body growth by targeting sNPFR1/NPYR[NATURE COMMUNICATIONS,2015-07-03] -  Polo Kinase Phosphorylates Miro to Control ER-Mitochondria Contact Sites and Mitochondrial Ca(2+) Homeostasis in Neural Stem Cell Development[DEVELOPMENTAL CELL,2016-04-18] -  A chemical with proven clinical safety rescues Down-syndrome-related phenotypes in through DYRK1A inhibition[DISEASE MODELS & MECHANISMS,2016-08-01] -  High fat diet-induced TGF-beta/Gbb signaling provokes insulin resistance through the tribbles expression[SCIENTIFIC REPORTS,2016-08-03] -  The bantam microRNA acts through Numb to exert cell growth control and feedback regulation of Notch in tumor-forming stem cells in the Drosophila brain[ PLOS GENETICS,2017-05-17] -  The bantam microRNA acts through Numb to exert cell growth control and feedback regulation of Notch in tumor-forming stem cells in the Drosophila brain[ PLOS GENETICS,2017-05-17]

특허(최근 5년)

-  인간신경펩티드수용체 형질전환 초파리를 이용한 비만 치료제 스크리닝 방법[2014-04-30] -  인간 DYRK1A 유전자 형질전환 초파리를 이용한 치료제 스크리닝 방법[2014-09-29] -  CX-4945를 유효성분으로 함유하는 퇴행성 뇌질환 예방 및 치료용약학적조성물[2017-02-03]

연구과제 수행 실적

세포소기관 기반 생체에너지 항상성 조절 연구 표현형 기반 MSC (Multi-tRNA Synthetase Complex) 구성인자의 유전학적 상호작용 연구