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김정훈 교수

Jeong-Hoon Kim

INFO

  • 소속캠퍼스한국생명공학연구원 스쿨
  • 전공 생명과학
    (기능유전체학)
  • 연락처042-860-4264
  • 출신전공생화학
  • 학위박사
  • 최종출신대학한국과학기술원
  • 이메일

연구분야

후생생물학, 핵산생화학

epigenetics, nucleic acid biochemistry

대표연구실적

-  Kim, J. H., Saraf, A., Florens, L., Washburn, M., Workman, J. L. (2010) Gcn5 Regulates the dissociation of SWI/SNF from Chromatin by Acetylation of Swi2/Snf2. Genes and Dev., 24, 2766-2771 -  Kim, J. H., Workman, J. L. (2010) Histone acetylation in heterochromatin assembly Genes and Dev., 24, 738-740 -   Kim, J. H., Kim, H. D., Ryu, G. H., Kim, D. H., Hurwitz, J., Seo, Y. S. (2006) Isolation of human Dna2 endonuclease and characterization of its enzymatic properties. Nucleic Acids Res., 34, 1854-1864.

논문(최근 5년)

-  Expression of the pro-domain-deleted active form of caspase-6 in Escherichia coli.[J. microbiol Biotechnol,2014-05-01] -  Identification of Novel Binding Partners for Caspase-6 Using a Proteomic Approach[J. microbiol Biotechnol,2014-05-01] -  Identification of a novel SHP-2 protein tyrosine ohosphatase inhibitor[B chem soc jpn,2014-05-01] -  Perspectives on the therapeutic potential of short-chain fatty acid receptors.[BMBRep,2014-03-03] -  Swi/Snf dynamics on stress-responsive genes is governed by competitive bromodomain interactions[GENES & DEVELOPMENT,2014-10-15] -  Synergistic effect of two E2 ubiquitin conjugating enzymes in SCF(hFBH1) catalyzed polyubiquitination[BMB REPORTS,2015-01-01] -  HAX1 regulates E3 ubiquitin ligase activity of cIAPs by promoting their dimerization[ONCOTARGET,2014-10-30] -  Cohesion Establishment Factors Stimulate Endonuclease Activity of hFen1 Independently and Cooperatively[JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY,2015-10-01] -  Histone H3 is digested by granzyme A during compromised cell death in the Raji cells[JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY,2015-09-01] -  Cell cycle-dependent Cdc25C phosphatase determines cell survival by regulating apoptosis signal-regulating kinase 1[CELL DEATH AND DIFFERENTIATION,2015-10-01] -  Scaffold role of DUSP22 in ASK1-MKK7-JNK signaling pathway[PLOS ONE,2016-10-06] -  Set7/9, a methyltransferase, regulates the thermogenic program during brown adipocyte differentiation through the modulation of p53 acetylation[ MOLECULAR AND CELLULAR ENDOCRINOLOGY,2016-08-15] -  Human ChlR1 stimulates endonuclease activity of hFen1 independently of ATPase activity[ BULLETIN OF THE KOREAN CHEMICAL SOCIETY,2014-10-20] -  cIAPs promote the proteasomal degradation of mutant SOD1 linked to familiar amyotrophic lateral sclerosis[BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2016-10-01] -  histone lysine methylation and neurodevelopmental disorders[INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2017-07-01] -  phamarcological intervention of early neuropathy in neurodegenrative diseases[PHARMACOLOGICAL RESEARCH,2017-02-04] -  The p90 RSK/UBR5 pathway controls Toll like receptor signaling via miRNA-induced translational inhibition of tumor necrosis factor associated factor3[JOURNAL OF BIOLOGICAL CHEMISTRY,2017-05-30] -  chromatin changes associated with neuronal maintenance and their pharmacological application[CURRENT NEUROPHARMACOLOGY,2018-01-01]

특허(최근 5년)

-  PTP-RE를 이용한 갈색 지방세포 분화 조절 방법[2015-11-20] -  소포체(ER) 스트레스로 인한 세포 사멸을 약화시키는 AGR2 호모-다이머(homo-dimer)[2016-01-19] -  마이크로박테리움 트리코테세놀리티쿰 균주를 이용하는 진세노사이드 Rb1을 Rd 또는 Rh2로의 생물 전환 방법[2015-02-24] -  질량분석방법[2017-09-04] -  소포체 스트레스로 인한 세포사멸을 약화시키는 AGR2 호모 다이머[2016-06-23] -  이온화 질량분석법 및 이를 이용한 질량분석장치[2017-08-08] -  Hax1 억제제를 유효성분으로 포함하는 염증성 질환 예방 또는 치료용 약학적 조성물 및 이를 이용한 스크리닝 방법[2017-05-08]

연구과제 수행 실적

멀티오믹스 검증 및 신규 E3 ligase/binder 도출연구 질환표적의 구조 기반 기능제어 기술개발 천연물 소재를 활용한 항노화 화장품 개발 및 사업화