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박병철 교수

Park Byoung Chul

INFO

  • 소속캠퍼스한국생명공학연구원 스쿨
  • 전공 생명과학
    (단백체구조생물학)
  • 연락처042-860-4260
  • 출신전공생화확
  • 학위박사
  • 최종출신대학한국과학기술원
  • 이메일

연구분야

암 및 면역질환 단백체연구. 구조 기능, 신호전달,

Proteomics study of cancer metastasis and auto immune disorder, Structure and Function,

대표연구실적

-  박병철 외/A critical step for JNK activation: isomerization by the prolyl isomerase Pin1 /CELL DEATH AND DIFFERENTIATION 2012 -  박병철 외 /Dimerization of pro-oncogenic protein Anterior Gradient 2 is required for the interaction with BiP/GRP78/Biochem Biophys Res Commun 2013 -  박병철 외/Positive regulation of apoptosis signal-regulating kinase 1 by dual-specificity phosphatase 13A/ CELLULAR AND MOLECULAR LIFE SCIENCES 2011

논문(최근 5년)

-  Human ChlR1 stimulates endonuclease activity of hFen1 independently of ATPase activity[BULLETIN OF KOREAN CHEMICAL SOCIETY,2014-10-01] -  Expression of the pro-domain-deleted active form of caspase-6 in Escherichia coli[JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY,2014-09-01] -  HAX1 regulates E3 ubiquitin ligases activity of cIAPs by promoting their dimerization[Oncotargets,2014-09-01] -  Identification of a novel SHP-2 protein tyrosine phosphatase inhibitor[BULLETIN OF CHEMICAL SOCIETY OF JAPAN,2014-08-09] -  A conserved mechanism for binding of p53 DNA-binding domain and anti-apoptotic Bcl-2 family proteins[MOLECULES AND CELLS,2014-08-08] -  Comparative proteomic analyses of synovial fluids and serums from rheumatoid arthritis patients[JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY,2014-08-02] -  Identification of novel binding partners for caspase-6 using a proteomic approach[JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY,2014-05-01] -  Cell cycle-dependent Cdc25C phosphatase determines cell survival by regulating apoptosis signal-regulating kinase 1[ CELL DEATH AND DIFFERENTIATION,2015-11-11] -  Cohesion establishment factors stimulate endonuclease activity of hFen1 independently and cooperatively[ JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY,2015-01-02] -  Crystal structure of the fungal nitroreductase Frm2 from Saccharomyces cerevisiae[ PROTEIN SCIENCE,2015-09-02] -  Histone H3 is digested by granzyme A during compromised cell death in the Raji cells[ JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY,2015-11-09] -  Peltier heating-assisted low temperature plasma ionization for ambient mass spectrometry[Mass Spectrometry Letters,2015-11-20] -  Structural convergence of unstructured p53 family transactivation domains in mdm2 recognition[ CELL CYCLE,2015-01-15] -  Synergistic effect of two E2 ubiquitin conjugating enzymes in SCF(hFBH1) catalyzed polyubiquitination[ BMB REPORTS,2015-09-09] -  Histone H4 is cleaved by granzyme A during staurosporine-induced cell death in B-lymphoid Raji cells[ BMB REPORTS,2016-07-20] -  Preformulation of FK506 prodrugs for improving solubility = FK506[ BULLETIN OF THE KOREAN CHEMICAL SOCIETY,2016-08-04] -  Scaffold role of DUSP22 in ASK1-MKK7-JNK signaling pathway[ PLOS ONE,2016-10-06] -  The p90 ribosomal S6 kinase-UBR5 pathway controls Toll-like receptor signaling via miRNA-induced translational inhibition of tumor necrosis factor receptor?associated factor 3 [ JOURNAL OF BIOLOGICAL CHEMISTRY,2017-05-03] -  cIAPs promote the proteasomal degradation of mutant SOD1 linked to familial amyotrophic lateral sclerosis[ BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2016-11-18] -  A Bacterial Metabolite, Compound K, Induces Programmed Necrosis in MCF-7 Cells via GSK3β[ JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY,2015-06-01] -  Barrier protection via?Toll-like receptor 2 signaling in?porcine intestinal epithelial cells damaged by?deoxynivalnol[ VETERINARY RESEARCH,2016-02-01] -  Distinct pattern of immune tolerance in dendritic cells treated with lipopolysaccharide or lipoteichoic acid[ MOLECULAR IMMUNOLOGY,2017-11-01]

특허(최근 5년)

-  질량분석 방법[2017-09-04] -  이온화 질량분석법 및 이를 이용한 질량분석장치[2017-08-08] -  HAX1 억제제를 유효성분으로 포함하는 염증성 질환 예방 또는 치료용 약학적 조성물 및 이를 이용한 스크리닝 방법[2017-05-08] -  마이크로박테리움 트리코테세놀리티쿰 균주를 이용하는 진세노사이드 Rb1을 Rd 또는 Rh2로의 생물 전환 방법[2015-02-24] -  소포체(ER) 스트레스로 인한 세포 사멸을 약화시키는 AGR2 호모-다이머(homo-dimer)[2016-01-19] -  이온화 질량분석법 및 이를 이용한 질량분석장치[2016-10-25] -  질량분석 방법[2017-03-13]

연구과제 수행 실적

멀티오믹스검증 및 신규 E3 ligase 도출 연구