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이진혁 교수

Lee, Jinhyuk

INFO

  • 소속캠퍼스한국생명공학연구원 스쿨
  • 전공 생명과학
    (생명정보학)
  • 연락처042-879-8530
  • 출신전공물리화학
  • 학위박사
  • 최종출신대학서울대학교
  • 이메일
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연구분야

빅데이터 인공지능을 이용한 신약개발 후보물질 발굴, 단백질 구조 모델링, 분자동력학 시뮬레이션, 가상 스크리닝

Big data driven based on AI drug candidate discovery, Protein Structure modeling, Molecular dynamics simulation, Protein-Ligand docking

대표연구실적

-  Z J Wang, S Ji, Y X Si, J M Yang, G Y Qian, Jinhyuk Lee, S J Yin?(2013)?"The effect of validamycin A on tyrosinase: Inhibition kinetics and computational simulation"?INT J BIOL MACROMOL.?55(0)?:?15-23. -  T R Kim, Sunyoung Ji, Sanghyuk Lee, In-Sun Chu, S Shin, Jinhyuk Lee?(2012)?"A hybrid modeling strategy using Nuclear Overhauser Effect data with contact information"?CHEM PHYS LETT.?554(0)?:?190-194. -  T R Kim, Sangho Oh, Joshua Sungwoo Yang, Sanghyuk Lee, S Shin, Jinhyuk Lee?(2012)?"A simplified homology-model builder toward highly protein-like structures: An inspection of restraining potentials"?J COMPUT CHEM.?33(24)?:?1927-1935.

논문(최근 5년)

-  A pathway-based approach for identifying biomarkers of tumor progression to trastuzumab-resistant breast cancer[ CANCER LETTERS,2014-11-01] -  Mutations in DDX58, which Encodes RIG-I, Cause Atypical Singleton-Merten Syndrome[ AMERICAN JOURNAL OF HUMAN GENETICS,2015-01-01] -  The effect of Cu2+ on arginine kinase from Euphausia superba: A computational simulation integrating unfolding and aggregation studies[ PROCESS BIOCHEMISTRY,2014-12-27] -  The effect of Zn2+ on Exopalaemon carinicauda arginine kinase: computational simulation integrating unfolding kinetics[ PROCESS BIOCHEMISTRY,2014-12-27] -  Effect of Ba2+ on the activity and structure of α-glucosidase: inhibition kinetics and molecular dynamics simulation[ PROCESS BIOCHEMISTRY,2015-01-28] -  Molecular dynamics simulations integrating kinetics for Pb2+ induced arginine kinase inactivation and aggregation[ PROCESS BIOCHEMISTRY,2015-02-23] -  Network comparison of inflammation in colorectal cancer and Alzheimer’s disease[ BIOMED RESEARCH INTERNATIONAL,2015-01-01] -  Effects of L-malic acid on alpha-glucosidase: inhibition kinetics and computational molecular dynamics simulations[ APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY,2014-12-05] -  The inhibitory effects of Cu2+ on Exopalaemon carinicauda arginine kinase via inhibition kinetics and molecular dynamics simulations[ APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY,2015-05-01] -  Integration of inhibition kinetics and molecular dynamics simulations to determine the effects of Zn2+ on acetaldehyde dehydrogenase 1[ PROCESS BIOCHEMISTRY,2015-07-07] -  Molecular dynamics simulation integrating study for Cr3+-binding to arginine kinase[ PROCESS BIOCHEMISTRY,2015-06-03] -  Verproside inhibits TNF-α-induced MUC5AC expression through suppression of the TNF-α/NF-κB pathway in human airway epithelial cells[ CYTOKINE,2015-08-28] -  Protein Structure Determination by Conformational Space Annealing Using NMR Geometric Restraints[ PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS,2015-10-10] -  Semi-Empirical Structure Determination of Escherichia coli Hsp33 and Identification of Dynamic Regulatory Elements for the Activation Process[ JOURNAL OF MOLECULAR BIOLOGY,2015-10-01] -  NMRe: a web server for NMR protein structure refinement with high-quality structure validation scores[ BIOINFORMATICS,2015-10-26] -  Effects of cadmium on the cuttlefish Sepia pharaonis arginine kinase: unfolding kinetics integrated with computational simulations[ JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS,2016-01-01] -  The effect of Cd2+ on muscle type of creatine kinase: inhibition kinetics integrating computational simulations[ INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2015-11-28] -  Effect of Hydroxysafflor Yellow A on Tyrosinase: Integration of Inhibition Kinetics with Computational Simulation[ PROCESS BIOCHEMISTRY,2015-09-26] -  Discovery of polymethoxyflavones from black ginger (Kaempferia parviflora) as potential β-secretase (BACE1) inhibitors[ JOURNAL OF FUNCTIONAL FOODS,2015-12-02] -  Directly converted patient-specific induced neurons mirror the neuropathology of FUS with disrupted nuclear localization in amyotrophic lateral sclerosis[ MOLECULAR NEURODEGENERATION,2016-01-01] -  Designing an Antibody-based Chaperoning System through Programming the Binding and Release of Folding Intermediate[ ACS CHEMICAL BIOLOGY,2016-06-01] -  Integration of Inhibition Kinetics and Molecular Dynamics Simulations: A Urea-Mediated Folding Study on Acetaldehyde Dehydrogenase 1[ APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY,2016-05-01] -  Effect of Cadmium Ion on alpha-glucosidase: An inhibition kinetics and molecular dynamics simulation integration study[ PROTEIN JOURNAL,2016-05-05] -  A computational integrating kinetic study on the flexible active site of human acetaldehyde dehydrogenase 1[ PROCESS BIOCHEMISTRY,2016-03-15] -  Anti-obesity effects of spiramycin in vitro and in vivo[ PLOS ONE,2016-07-11] -  Effect of Cd2+ on tyrosinase: integration of inhibition kinetics with computational simulation[ INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2016-09-11] -  Identification of biochanin A as a potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitor[ NUTRIENTS,2016-10-14] -  Clinical Relevance and Molecular Phenotypes in Gastric Cancer, of TP53 Mutations and Gene Expressions, in Combination With Other Gene Mutations[ SCIENTIFIC REPORTS,2016-10-06] -  Systematic approach in identifying RHOA as a Potential Asian Gastric Cancer Biomarker Therapeutic Target[ ONCOTARGET,2016-10-28] -  Mg2+ effect on Argonaute and RNA duplex by molecular dynamics and bioinformatics implications[ PLOS ONE,2014-10-14]