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김보연 교수

Bo Yeon Kim


  • 소속캠퍼스한국생명공학연구원 스쿨
  • 전공 생명과학
  • 연락처043-240-6163
  • 출신전공분자생물
  • 학위박사
  • 최종출신대학서울대학교
  • 이메일


암신호전달, 항암제발굴, 골다공증, 단백질분해

Cancer Signaling, Anticancer drug discovery, Osteoporosis. Protein degradation


-  Shashikanth M. Sriram, Bo Yeon Kim, and Yong Tae Kwon*. The N-end rule pathway: emerging functions and molecular principles of substrate recognition. Nature Reviews Molecular Cell Biology, 12(11), 735-747, 2011.. -  Takafumi Tasaki , Sung Tae Kim , Adriana Zakrzewska , Bo Eun Lee , Minjueng Kang , Young Dong Yoo , Joonsung Hwang , Nak Kyun Sung , Minh Dang Nguyen , Ming Sun , Eugene Yi , Bo-Yeon Kim*, Yong Tae Kwon*. UBR box N-recognin-4 (UBR4), an N-recognin of the N-end rule pathway, and its role in yolk sac vascular development and autophagy. UBR box N-recognin-4 (UBR4), an N-recognin of the N-end rule pathway, and its role in yolk sac vascular development and autophagy. Proc.Natl. Acad. Sci, USA, 110(10), 3800-3805, 2013. -  Haidan Liu, Kangdong Liu, Zunnan Huang, In-Ja Ryoo, Chan-Mi Park, Long He, Sun-Ok Kim, Naomi Oi, Ki-Won Lee, Nak-Kyun Soung, Ann M.Bode, Raymond L. Erikson, Zigang Dong*, Bo-Yeon Kim*. A chrysin derivative suppresses EGF-induced anchorage-independent growth of mouse epidermal JB6 P+ cells by inhibiting Cdks. J. Biol. Chem, 288(36), 25924-25937. 2013.

논문(최근 5년)

-  p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis[NATURE COMMUNICATIONS,2017-08-15] -  The fungal metabolite Brefeldin A inhibits Dvl2-Plk1-dependent primary cilium disassembly[ MOLECULES AND CELLS,2017-06-14] -  Glipma-derived cancer stem cells are hypersensitive to proteasomal inhibition[ EMBO REPORTS,2017-01-10] -  Polyketides and anthranilic acid possessing 6-deoxy-a-l-talopyranose from a Streptomyces species[ JOURNAL OF NATURAL PRODUCTS,2017-04-13] -  Anticancer activity of a novel small molecule tubulin inhibiotr STK899704[ONCOTARGET,2016-11-15] -  Anticancer activity of a novel small molucule tubulin inhibitor STK899704[PLOS ONE,2017-03-01] -  Cystatin SN inhibits auranofin-induced cell death by autophagic induction and ROS regulation via gutathione reductase activity in colorectal cancer[Cell Death and Disease,2017-03-16] -  Ginsenoside Re inhibits osteoclast disfferentiation in mouse bone marrow-derived macrophages and zebrafish scale model[ MOLECULES AND CELLS,2016-12-06] -  Ginsenoside Re promotes osteoblast differentiation in mouse osteoblast precursor MC3T3-E1 cells and a zebrafish model[MOLECULES,2016-12-29] -  The arginylation branch of the N-end rule pathway positively regulates cellular autophagic flux and clearannce of proteotoxic proteins[AUTOPHAGY,2016-08-05] -  IGF-II induced by hepatitis B virus X protein regulates EMT via SUMO mediated loss of E-cadherin in mice[ONCOTARGET,2016-07-29] -  Modulation of SQSTM1/p62 activity by N-terminal arginylation of the endoplasmic reticulum chaperone HSPA5/GRP78/Bip[AUTOPHAGY,2016-11-05] -  Stachybotrysin, an osteoclast differentiation inhibitor from the marine-derived fungus Stachybotrys sp. KCB13F013[ JOURNAL OF NATURAL PRODUCTS,2016-10-11] -  Crystal structure of SP-PTP, a low mulecular weight protein tyrosine phsphatase from Streptocuccus pyogenes[ BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2016-08-19] -  Peroxiredoxin II promotes hepatic tumorigenesis through cooperation with Ras/Forkhead box M1 signal pathway[ ONCOGENE,2015-10-26] -  Dehydropeptidase 1 promotes metastasis through regulatio nof E-cadherin expression in colon cancer[ONCOTARGET,2016-01-27] -  New cyclic lipopeptides of the iturin class produced by saltern-derived Bacillus sp. KCB14S006[MARINE DRUGS,2014-04-02] -  Epigenetic modification of TLR4 prdomotes activation of NF-kB by regulating methyl-CpG-binding domain protein 2 and Sp1 in gastric cancer[ONCOTARGET,2016-01-10] -  Structural study of the HD-PTP Bro1 domain in a complex with the core region of STAM2, a subunit of ESCRT-0[PLOS ONE,2016-02-11] -  Structural and biological activities of azaphilones produced by Penicillium sp. KCB11A109 from a ginseng field[ PHYTOCHEMISTRY,2016-02-10] -  Selective blockade of cancer cell proliferation and anchorage-independent growth by Plk1 activity-dependent suididal inhibition of its polo-box domain[ CELL CYCLE,2015-10-30] -  Haenamindole, an unusual diketopiperazine derivative from a marine-derived Penilillium sp. KCB12F005 [ BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2015-09-10] -  Amino-terminal arginylation as a degradation signal for selective autophagy[ BMB REPORTS,2015-11-10] -  Synthesis and Antitumor Activity of Natural Compound Aloe Emodin Derivatives[ CHEMICAL BIOLOGY & DRUG DESIGN,2015-01-20] -  Decreased expression of Toll-like receptor 4 and 5 during progression of prostate transformation in transgenic adenocarcinoma of mouse prostate mice[ JOURNAL OF VETERINARY SCIENCE,2015-04-05] -  ulleungamides A and B, modified a,b-dehydropipecolic acid containing cyclic depsipetides from Streptomyces sp.KCB13F003[ ORGANIC LETTERS,2015-08-11] -  Eupafolin suppresses prostate cancer by targeting phosphatidylinositol 3-kinase-mediated Akt signaling[ MOLECULAR CARCINOGENESIS,2015-05-05]

특허(최근 5년)

-  신규 튜뷸린 중합 저해제 및 그 합성방법[2017-05-09] -  p62 ZZ 도메인에 결합하는 리간드 또는 아르기닌화된 Bip에 의해 매개되는 오토파지 활성을 통한 신경변성 질환 예방 및 치료[2017-04-25] -  Composition for prevention or treatment of cancer comprising N-methylenenaphtho[2,1-b]furan-2-Carbohydrazide derivatives as an active ingredient[2016-09-06] -  신규한 고리형 뎁시펩타이드계 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 항균용 약학적 조성물[2016-10-26] -  페닐 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 세포증식성 질병의 예방 또는 치료용 약학적 조성물[2017-03-24] -  필라그린 유전자 돌연변이 검출용 프로브, 키트 및 방법[2016-06-24] -  해양 진균에서 분리한 페니실리놀라이드 A를 유효성분으로 함유하는 염증성 질환 예방 및 치료용 조성물[2016-05-06] -  신규 튜뷸린 중합 저해제 및 그 합성방법[2016-01-06] -  아르기닌화된 ER 단백질에 특이적으로 결합하는 항체 및 이의 용도[2017-05-04] -  p62 ZZ 영역에 의해 매개되는 자가포식 조절방법 및 그 용도[2016-02-04] -  N-메틸렌나프토[2,1-b]퓨란-2-카보하이드라지드 유도체를 유효성분으로 포함하는 암 예방 또는 치료용 [2015-10-28] -  신규한 이모딘 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 암질환 예방 또는 치료용 약학적 조성물[2015-01-13] -  신규한 푸사리세틴 화합물 및 이의 용도[2015-04-10] -  신규한 푸사리세틴 화합물 및 이의 용도[2014-12-23] -  신규한 프로투복세핀 A,B 및 프로투보닌 A 화합물 및 이를 항유하는 암예방 또는 치료용 약학적 조성물[2014-09-18]

연구과제 수행 실적

창의형융합연구사업(에피프로테옴 기반 발암 및 암전이 치료 신규 원천기술 개발)