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장재혁 교수

JANG JAEHYUK

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  • 소속캠퍼스한국생명공학연구원 스쿨
  • 전공 생명과학
    (생체분자과학)
  • 연락처043-240-6164
  • 출신전공해양천연물화학
  • 학위박사
  • 최종출신대학University of Tokyo
  • 이메일

연구분야

육상, 해양 미생물 유래 천연물화학, 천연물구조해석, 화학생물학

Microbial Natural Product Chemistry, Structure Determination of NP, Chemical Biology

대표연구실적

-  Jae-Hyuk Jang, Yukihiro Asami, Jun-Pil Jang, Sun-Ok Kim, Dong Oh Moon, Kee-Sun Shin, Daisuke Hashizume, Makoto Muroi, Tamio Saito, Hyuncheol Oh, Bo Yeon Kim, Hiroyuki Osada, and Jong Seog Ahn ,Fusarisetin A, An Acinar Morphogenesis Inhibitor from a Soil Fungus, Fusarium sp. FN080326, Journal of the American Chemical Society, 133 (18), 6865-6867 (2011) -  Sangkeun Son, Mina Jang, Sung-Kyun Ko, Jae Kyoung Lee, In-Ja Ryoo, Jung-Sook Lee, Young-Soo Hong, Bo Yeon Kim, Jae-Hyuk Jang, and Jong Seog Ahn, Polyketides and Anthranilic Acid Possessing 6-Deoxy-α-L-talopyranose from Streptomyces sp., Journal of Natural Products, 80(5), 1378-1386 (2017) -  Sangkeun Son, Sung-Kyun Ko, Mina Jang, Jae Kyoung Lee, In-Ja Ryoo, Jung-Sook Lee, Kyung Ho Lee, Nak-Kyun Soung, Hyuncheol Oh, Young-Soo Hong, Bo Yeon Kim, Jae-Hyuk Jang, and Jong Seog Ahn, Ulleungamides A and B, Modified α,β-Dehydropipecolic Acid Containing Cyclic Depsipeptides from Streptomyces sp. KCB13F003, Organic Letters, 17 (16), 4046-4049 (2015)

논문(최근 5년)

-  Boseongazepines A-C Pyrrolobenzodiazepine Derivatives from a Streptomyces sp. 11A057[Bioorganic & Medicinal Chemistry Letters,2014-04-01] -  Inhibition of indoleamine 2 3-dioxygenase by thielavin derivatives from a soil fungus Coniochaeta sp. 10F058[The Journal of Antibiotics,2014-05-01] -  Hypo-pigmenting effect of sesquiterpenes from Inula Britannica in B16 melanoma cells[Arch. Pharm. Res.,2014-05-01] -  Illudins C2 and C3 Stimulate Lipolysis in 3T3-L1 Adipocytes and Suppress Adipogenesis in 3T3-L1 Preadipocytes[Journal of Natural Products,2014-04-01] -  Chemical constituents of the Korean endangered species Rhododendron brachycarpum[Biochemical Systematics and Ecology,2014-06-01] -  Biosynthesis of methylated resveratrol analogs through the construction of an artificial biosynthetic pathway in E. coli[BMC Biotechnology,2014-07-17] -  RK-270A-C, new oxindole derivatives isolated from a microbial metabolites fraction library of Streptomyces sp. RK85-270[ JOURNAL OF ANTIBIOTICS,2015-01-01] -  Pectate Lyase-Coding Gene Abundantly Expressed during Early Stages of Infection Is Required for Full Virulence in Alternaria brassicicola[PLOS ONE,2015-01-01] -  A new enzyme involved in the control of the stereochemistry in the decalin formation during equisetin biosynthesis[BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2015-01-01] -  Eupafolin Suppresses Prostate Cancer by Targeting Phosphatidylinositol 3-Kinase-Mediated Akt Signaling[ MOLECULAR CARCINOGENESIS,2015-01-01] -  Ulleungamides A and B, Modified α,β-Dehydropipecolic Acid Containing Cyclic Depsipeptides from Streptomyces sp. KCB13F003[ ORGANIC LETTERS,2015-01-01] -  Haenamindole, an unusual diketopiperazine derivative from a marine-derived Penicillium sp. KCB12F005[ BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2015-01-01] -  Cycloexpansamines A and B: spiroindolinone alkaloids from a marine isolate of Penicillium sp. (SF-5292)[ JOURNAL OF ANTIBIOTICS,2015-01-01] -  Production of phenylacetyl-homoserine lactone analogs by artificial biosynthetic pathway in Escherichia coli[MICROBIAL CELL FACTORIES,2015-01-01] -  Synthesis and antitumor activity of natural compound Aloe emodin derivatives[ CHEMICAL BIOLOGY & DRUG DESIGN,2015-01-01] -  Penidioxolanes A and B, 1,3-dioxolane containing azaphilone derivatives from marine-derived Penicillium sp. KCB12C078[Natural Product Sciences,2015-01-01] -  Inhibitory effects of alternaramide on inflammatory mediator expression through TLR4-MyD88-mediated inhibition of NF-kB and MAPK pathway signaling in lipopolysaccharide-stimulated RAW264.7 and BV2 cells[ CHEMICO-BIOLOGICAL INTERACTIONS,2016-01-01] -  Structures and Biological Activities of Azaphilones Produced by Penicillium sp. KCB11A109 from a Ginseng Field[ PHYTOCHEMISTRY,2016-01-01] -  Trapa japonica pericarp extract reduces LPS-induced inflammation in macrophages and acute lung injury in mice[MOLECULES,2016-01-01] -  Characterization of the antioxidant fraction of Trapa japonica pericarp and its hepatic protective effects in vitro and in vivo[FOOD & FUNCTION,2016-01-01] -  Anti-neuroinflammatory effects of citreohybridonol involving TLR4-MyD88-mediated inhibition of NF-кB and MAPK signaling pathways in lipopolysaccharide-stimulated BV2 cells[ NEUROCHEMISTRY INTERNATIONAL,2016-01-01] -  New cyclic lipopeptides of the iturin class produced by saltern-derived Bacillus sp. KCB14S006[MARINE DRUGS,2016-01-01] -  Eighth Korea?Japan Chemical Biology symposium: chemical biology notes from a small island[ JOURNAL OF ANTIBIOTICS,2016-01-01] -  Stachybotrysin, an Osteoclast Differentiation Inhibitor from the Marine-derived Fungus Stachybotrys sp. KCB13F013[ JOURNAL OF NATURAL PRODUCTS,2016-01-01] -  Ginsenoside Re Inhibits Osteoclast Differentiation in Mouse Bone Marrow-Derived Macrophages and Zebrafish Scale Model[Molecules and Cells,2016-01-01] -  RK-144171, a new benadrostin derivative produced by Streptomyces sp. RK88-1441[ JOURNAL OF ANTIBIOTICS,2017-01-01] -  Polyketides and Anthranilic Acid Possessing 6-Deoxy-α-L-talopyranose from Streptomyces sp.[ JOURNAL OF NATURAL PRODUCTS,2017-01-01] -  Octaminomycins A and B, cyclic octadepsipeptides active against Plasmodium falciparum[ JOURNAL OF NATURAL PRODUCTS,2017-01-01] -  Identification of new geldanamycin derivatives from unexplored microbial culture extracts using a MS/MS library[ JOURNAL OF ANTIBIOTICS,2017-01-01] -  Anticancer activity of a novel small molecule tubulin inhibitor STK899704[ PLOS ONE,2017-01-01] -  The Fungal Metabolite Brefeldin A Inhibits Dvl2-Plk1-Dependent Primary Cilium Disassembly[Molecules and Cells,2017-01-01] -  Two Cyclic Hexapeptides from Penicillium sp. FN070315 with Antiangiogenic Activities[PLOS ONE,2017-01-01]

특허(최근 5년)

-  신규한 이모딘 유도체 이의 제조방법 및 이를 유효성분으로 함유하는 암질환 예방 또는 치료용 약학적 조성물[2015-01-13] -  신규 튜불린 중합 저해제 및 그 합성방법[2017-05-09] -  에틸(2―메틸―3―{(E)―[(나프타[2,1―b]퓨란―2―일카보닐)하이드라조노]메틸}―1H―인돌―1―일)아세테이트를 유효성분으로 포함하는 항암치료 및 예방용 조성물[2016-09-06] -  신규한 고리형 뎁시펩타이트계 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 항균용 약학적 조성물[2016-10-26] -  페닐 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 세포증식성 질병의 예방 또는 치료용 약학적 조성물[2017-03-24] -   해양 진균에서 분리한 페니실리놀라이드 A를 유효성분으로함유하는염증성질환예방및치료용 조성물 [2016-05-06] -   신규 튜불린 중합 저해제 및 그 합성방법 [2016-01-06] -  에틸(2―메틸―3―{(E)―[(나프타[2,1―b]퓨란―2―일카보닐)하이드라조노]메틸}―1H―인돌―1―일)아세테이트를 유효성분으로 포함하는 항암치료용 조성물[2015-10-28] -  신규한 푸사리세틴 화합물 및 이의 용도[2015-04-10] -  신규한 푸사리세틴 화합물 및 이의 용도[2014-12-23] -  신규한 프로투복세핀 A, B 및 프로투보닌 A 화합물 및 이를 함유하는 암 예방 또는 치료용 약학적 조성물[2014-09-18] -   신규한 푸사리세틴 화합물 및 이의 용도 [2016-06-22]

연구과제 수행 실적

미생물 유래 생리활성 대사산물 개발 에피프로테옴 기반 발암 및 암전이 치료 신규 원천기술 개발 항암 표적단백질 및 항암 선도물질 발굴 흑삼의 구성성분 분석 및 항당뇨 활성과의 상관성 해석