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김원곤 교수

Won-Gon Kim

INFO

  • 소속캠퍼스한국생명공학연구원 스쿨
  • 전공 생명과학
    (생체분자과학)
  • 연락처042-860-4298
  • 출신전공식품공학(미생물)
  • 학위박사
  • 최종출신대학서울대학교
  • 이메일

연구분야

미생물 천연물 화학/ 슈퍼박테리아 치료물질 연구/방선균 합성생물학

Microbial natural product chemistry/Study on anti-superbacterial compound/Streptomyces synthetic biology

대표연구실적

-  Bomin Kim, Ji-Su Park, Ha-Young Choi, Sang Sun Yoon, and Won-Gon Kim. Terrein is an inhibitor of quorum sensing and c-di-GMP in Pseudomonas aeruginosa: a connection between quorum sensing and c-di-GMP/Sci. Rep./2018.6.5 -  Chang-Ji Zheng, Mi-Jin Sohn and Won-Gon Kim/Vinaxanthone, a new FabI inhibitor from Penicillium sp./J. Antimicrob. Chemother./2009.5. -  Yun-Ju Kwon, Mi-Jin Sohn, Chang-Ji Zheng, Won-Gon Kim/ Fumimycin: a Peptide Deformylase Inhibitor with an Unprecedent Skeleton Produced by Aspergillus fumisynnematus./ Org. Lett./2007.6.21

논문(최근 5년)

-  The Lactone Form of Stachybotrydial: A New Inhibitor of Dihydrofolate Reductase from Stachybotrys sp. FN298.[Biol. Pharm. Bull.,2014-08-01] -  Complestatin Exerts Antibacterial Activity by the Inhibition of Fatty Acid Synthesis[ BIOLOGICAL & PHARMACEUTICAL BULLETIN,2015-05-01] -  Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson's disease.[ PROCEEDINGS OF THE ACADEMY OF NATURAL SCIENCES OF PHILADELPHIA,2015-06-14] -  Overexpression of the laeA gene leads to increased production of cyclopiazonic acid in Aspergillus fumisynnematus[ FUNGAL BIOLOGY,2015-11-01] -  Verrulactones D and E with unprecedented skeletons, new inhibitors of Staphylococcus aureus enoyl-ACP reductase, from Penicillium verruculosum F375[ JOURNAL OF ANTIBIOTICS,2015-08-26] -  AN483, a new anti-MRSA compound from Streptomyces sp.[ JOURNAL OF ANTIBIOTICS,2016-01-13] -  Daphnane diterpenes from Daphne genkwa activate Nurr1 and have a neuroprotective effect in an animal model of Parkinson’s disease.[ JOURNAL OF NATURAL PRODUCTS,2016-05-26] -  Isolation of coralmycins A and B, potent anti-Gram negative compounds from the myxobacteria Corallococcus coralloides M23.[ JOURNAL OF NATURAL PRODUCTS,2016-09-06] -  Generation of new complestatin analogues by heterologous expression of the complestatin biosynthetic gene cluster from Streptomyces chartreusis AN1542[ CHEMBIOCHEM,2016-08-02] -  Improvement of the pharmacological activity of menthol via enzymatic b-anomer-selective glycosylation[ AMB EXPRESS,2017-08-29] -  Madurahydroxylactone, an Inhibitor of Staphylococcus aureus FtsZ from Nonomuraea sp. AN100570[JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY,2017-11-30] -  Daphnane and Phorbol Diterpenes, Anti-Neuroinflammatory Compounds with Nurr1 Activation from the Roots and Stem40s of Daphne genkwa.[BIOLOGICAL & PHARMACEUTICAL BULLETIN,2017-12-01] -  Genomics-Driven Discovery of Chlorinated Cyclic Hexapeptides Ulleungmycins A and B from a Streptomyces Species.[JOURNAL OF NATURAL PRODUCTS,2017-10-30] -  Production of bacterial quorum sensing antagonists, caffeoyl- and feruloyl-HSL, by an artificial biosynthetic pathway[JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY,2017-12-18] -  Genkwalathins A and B, new lathyrane-type diterpenes from Daphne genkwa.[NATURAL PRODUCT RESEARCH,2018-08-01] -  Enzymatic synthesis of avermectin B1a glycosides for the effective prevention of the pine wood nematode Bursaphelenchus xylophilus.[APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2018-01-25] -  Terrein is an inhibitor of quorum sensing and c-di-GMP in Pseudomonas aeruginosa: a connection between quorum sensing and c-di-GMP. [SCIENTIFIC REPORTS,2018-06-05]

특허(최근 5년)

-  신규한 항균성 화합물[2016-08-03] -  멘솔 배당체를 포함하는 피부 보습용 조성물 및 이의 제조방법[2017-03-21] -  신규한 에포싸일론 유도체 및 그의 용도[2016-07-04] -  펩티드 디포밀라제 저해 및 항균 활성을 갖는 신규한 프라비마이신 화합물[2017-07-27] -  신규한 항균성 화합물[2015-02-26]

연구과제 수행 실적

뇌질환성 운동장애 예방 및 개선을 위한 건강기능식품 소재 개발 다제내성균 치료 신규 항세균 후보물질 개발 신개념 그람음성 박테리아 항세균 물질 연구