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한백수 교수

Han Baek-Soo

INFO

  • 소속캠퍼스한국생명공학연구원 스쿨
  • 전공 생명과학
    (기능유전체학)
  • 연락처042-879-8438
  • 출신전공생물학
  • 학위박사
  • 최종출신대학연세대학교
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연구분야

퇴행성 신경계 질환 및 줄기세포 기반 신경세포 분화

Neurodegenerative disorder and neuronal differentiation with hES or iPS cells

대표연구실적

-  Baek-Soo Han, Hyun-sung Hong, Won-Seok Choi, George j. Markelonis, Tae H. Oh and Young J. Oh. Caspase-dependent and -independent cell death pathways in primary cultures of mesencephalic dopaminergic neurons after neurotoxins treatment. Journal of Neuroscience. 2003, 23(12): 5069-78 -  Baek-Soo Han, Hee-won Kang, Soo-Jung Lim, Young J. Oh. Mechanisms to prevent caspase activation in rotenone-induced dopaminergic neurodegeneration: role of ATP depletion and procaspase-9 degradation. Apoptosis. 2012. Feb 1 -  Baek-Soo Han, Chang-Ki Oh, Young J. Oh. Translocation and oligomerization of Bax is regulated independently by reactive oxygen species-mediated activation of caspase-2 and p38 MAPK during dopaminergic neurodegeneration. Apoptosis. 2011. 16:1087-1100

논문(최근 5년)

-  Identification of DNA Aptamers toward Epithelial Cell Adhesion Molecule via Cell-SELEX[MOL CELLS,2014-09-29] -  Monitoring the differentiation and migration patterns of neural cells derived from human embryonic stem cells using a microfluidic culture system[MOL CELLS,2014-06-01] -  Pitx3 deficient mice as a genetic animal model of co-morbid depressive disorder and parkinsonism[BRAIN RES,2014-03-13] -  Proteomic analysis of the effect of retinoic acids on the human breast cancer cell line MCF-7[MOL BIOL REP,2014-05-01] -  Selection of aptamers for mature white adipocytes by cell SELEX using flow cytometry[PLOS ONE,2014-05-20] -  Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson’s disease[PNAS,2015-07-14] -  DUSP4 Regulates Neuronal Differentiation and Calcium Homeostasis by Modulating ERK1/2 Phosphorylation[Stem cells and Development,2015-03-15] -  Recent advances in proteomic studies of adipose tissues and adipocytes[INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2015-02-27] -  Stimulation of angiogenesis and survival of endothelial cells by human monoclonal Tie2 receptor antibody[Biometerials,2015-05-01] -  Phosphoprotein phosphatase 1CB (PPP1CB) a novel adipogenic activator promotes 3T3-L1 adipogenesis[Biochem Biophys Res Commun.,2015-11-13] -  MKP kinase phosphatase 3 inhibits brown adipocyte differentiation via regulation of Erk phosphorylation[Mol Cell Endocrinol.,2015-11-15] -  Intracellular annexin A2 regulates NF-κB signaling by binding to the p50 subunit: implications for gemcitabine resistance in pancreatic cancer[Cell Death Dis,2015-01-22] -  c-Jun regulates adipocyte differentiation via the KLF15-mediated mode[ BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2016-01-15] -  Profiling analysis of protein tyrosine phosphatases during neuronal differentiation[ NEUROSCIENCE LETTERS,2016-01-26] -  Set7/9, a methyltransferase, regulates the thermogenic program during brown adipocyte differentiation through the modulation of p53 acetylation.[ MOLECULAR AND CELLULAR ENDOCRINOLOGY,2016-08-15] -  Methyltransferase and demethylase profiling studies during brown adipocyte differentiation[ BMB REPORTS,2016-07-01] -  Graphene oxide induces apoptotic cell death in endothelial cells by activating autophagy via calcium-dependent phosphorylation of c-Jun N-terminal kinases[ ACTA BIOMATERIALIA,2016-12-01] -  Metabolic Adaptation in Obesity and Type II Diabetes: Myokines, Adipokines and Hepatokines.[ INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2016-12-22] -  HDAC11 Inhibits Myoblast Differentiation through Repression of MyoD-Dependent Transcription[ MOLECULES AND CELLS,2017-09-30] -  Use of Microfluidic Technology to Monitor the Differentiation and Migration of Human ESC-Derived Neural Cells[Methods in molecular biology (Clifton, N.J.),2016-04-10] -  Daphnane Diterpenes from Daphne genkwa Activate Nurr1 and Have a Neuroprotective Effect in an Animal Model of Parkinson's Disease[ JOURNAL OF NATURAL PRODUCTS,2016-06-24] -  Daphnane and phorbol diterpenes, anti-neuroinflammatory compounds with Nurr1 activation from the roots and stems of Daphne genkwa[BIOLOGICAL & PHARMACEUTICAL BULLETIN,2017-12-01] -  Genkwalathins A and B, new lathyrane-type diterpenes from Daphne genkwa[NATURAL PRODUCT RESEARCH,2017-11-20]

특허(최근 5년)

-  팥꽃나무 추출물을 포함하는 조성물[2014-07-29] -  병아리꽃나무 추출물을 포함하는 조성물[2015-08-25] -  팥꽃나무 추출물 또는 이로부터 분리된 화합물을 포함하는 신경퇴행성 질환 예방 또는 치료용 약학적 조성물[2015-05-19] -  MDH1의 아세틸화 억제제를 이용한 항비만용 조성물[2015-08-06] -  PTP-RE를 이용한 갈색 지방세포 분화 조절 방법[2015-11-20] -  콜린성 신경세포의 생산방법 [2017-09-08] -  코플린-1을 이용한 갈색 지방세포 분화 조절 방법 [2016-09-27] -  EpCAM에 특이적으로 결합하는 핵산 앱타머 및 이의 용도 [2016-07-18] -  신규한 신경세포 마커 및 이의 용도 [2016-09-28] -  팥꽃나무 추출물로부터 분리된 화합물을 포함하는 신경퇴행성 질환 예방 또는 치료용 약학적 조성물 [2016-06-13]

연구과제 수행 실적

의약품 적응외 사용 융합클러스터 줄기세포치료제 바이오마커의 유효성 검증 첨단바이오의약품 (세포-유전자치료제) 기술 분석 및 보급 치매 환자 기반 변이 유전자 기능 확인