본문 바로가기 대메뉴 바로가기
조성찬 교수

Cho, Sungchan

INFO

  • 소속캠퍼스한국생명공학연구원 스쿨
  • 전공 생명과학
    (생체분자과학)
  • 연락처043-240-6105
  • 출신전공생명과학
  • 학위박사
  • 최종출신대학포항공과대학교
  • 이메일

연구분야

척수성 근위축증, 퇴행성 뇌질환, 바이러스질환, 지질대사질환 치료용 후보물질 개발

Spinal muscular atrophy, Neurodegenerative diseases, Virus diseases, Metabolic diseases, Drug development

대표연구실적

-  Hyunju Kang, Jaehyung Song, Kwangman Choi, Hyeongki Kim, Miri Choi, So-Young Lee, Chonsaeng Kim, Sang Jun Lee, Moon Jung Song, Hyojeung Kang, Sung Hoon Back, Sang-Bae Han and Sungchan Cho. 2014. Efficient lytic induction of kaposi’s sarcoma-associated herpesvirus (KSHV) by the anthracyclines. Oncotarget. 5, 8515-8526 -  Hyeongki Kim, Kwangman Choi, Hyunju Kang, So-Young Lee, Seung-Wook Chi, Min-Sung Lee, Jaehyoung Song, Donghwa Im, Yura Choi, and Sungchan Cho. 2014. Identification of a Novel Function of CX-4945 as a Splicing Regulator. PLOS One. 9 -  Sungchan Cho and Gideon Dreyfuss. 2010. A Degron Created by SMN2 Exon7 Skipping is a Principal Contributor to Spinal Muscular Atrophy Severity. Genes & Development.24, 438-42.

논문(최근 5년)

-  The ubiquitin ligase human TRIM71 regulates let-7 microRNA biogenesis via modulation of Lin28B protein[BBA-Gene Regulatory Mechanisms,2014-03-03] -  Identification of a novel function of CX-4945 as a splicing regulator[PLoS one,2014-04-17] -  Regulation of diacylglycerol acyltransferase 2 protein stability by gp78-associated endoplasmic-reticulum-associated degradation[FEBS journal,2014-06-06] -  Discovery of a Novel Class of Diacylglycerol Acyltransferase 2 Inhibitors with a 1H-Pyrrolo[23-b]pyridine Core[Biological & Pharmaceutical Bulletin,2014-08-07] -  Efficient lytic induction of kaposi's sarcoma-associated herpesvirus (KSHV) by the anthracyclines[Oncotarget,2014-08-10] -  Antiviral activity of ginsenosides against coxsackievirus B3 enterovirus 71 and human rhinovirus 3[Journal of Ginseng Research,2014-07-07] -  Codycepin is a novel chemical suppressor of Epstein-Barr virus replication[Oncoscience,2014-12-18] -  Oleanane-type triterpenoids of Aceriphyllum rossii and their diacylglycerol acyltransferase-inhibitory activity.[ PLANTA MEDICA,2015-02-01] -  Antiviral Activity of Chrysin Derivatives against Coxsackievirus B3 in vitro and in vivo.[Biomolecules and Therapeutics,2015-09-01] -  Synergistic antiviral activity of gemcitabine and ribavirin against enteroviruses.[ ANTIVIRAL RESEARCH,2015-12-01] -  Selective novel inverse agonists for human GPR43 augment GLP-1 secretion.[ EUROPEAN JOURNAL OF PHARMACOLOGY,2016-01-15] -  Therapeutic and prophylactic activity of itraconazole against human rhinovirus infection in a murine model.[ SCIENTIFIC REPORTS,2016-03-15] -  Antiviral Activity of Oroxylin A against Coxsackievirus B3 Alleviates Virus-Induced Acute Pancreatic Damage in Mice.[ PLOS ONE,2016-05-19] -  Antiviral activity of micafungin against enterovirus 71.[ VIROLOGY JOURNAL,2016-06-13] -  Anti-Obesity Effects of Spiramycin In Vitro and In Vivo.[ PLOS ONE,2016-07-11] -  A chemical with proven clinical safety rescues Down-syndrome-related phenotypes in through DYRK1A inhibition.[ DISEASE MODELS & MECHANISMS,2016-08-01] -  MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) Interaction Disruptor Sensitizes Insulin Signaling in Skeletal Muscle.[ JOURNAL OF BIOLOGICAL CHEMISTRY,2016-12-23] -  TRIM71 suppresses tumorigenesis via modulation of Lin28B-let-7-HMGA2 signaling.[ ONCOTARGET,2016-11-29] -  Inactivation of human DGAT2 by oxidative stress on cysteine residues.[ PLOS ONE,2017-07-11] -  Antiviral activity of gemcitabine against human rhinovirus in vitro and in vivo.[ ANTIVIRAL RESEARCH,2017-09-01] -  SRSF2 directly inhibits intron splicing to suppresses cassette exon inclusion.[ BMB REPORTS,2017-08-01] -  The novel resveratrol derivative 3,5-diethoxy-3',4'-dihydroxy-trans-stilbene induces mitochondrial ROS-mediated ER stress and cell death in human hepatoma cells in vitro.[ ACTA PHARMACOLOGICA SINICA,2017-10-02] -  Gemcitabine, a broad-spectrum antiviral drug, suppresses enterovirus infections through innate immunity induced by the inhibition of pyrimidine biosynthesis and nucleotide depletion[Oncotarget,2017-12-15] -  Antiviral and anti-inflammatory activity of budesonide against human rhinovirus infection mediated via autophagy activation[ANTIVIRAL RESEARCH,2018-03-01] -  Gemcitabine and Nucleos(t)ide Synthesis Inhibitors Are Broad-Spectrum Antiviral Drugs that Activate Innate Immunity[VIRUSES-BASEL,2018-04-20] -  Arrayed CRISPR screen with image-based assay reliably uncovers host genes required for coxsackievirus infection[GENOME RESEARCH,2018-06-01] -  Antiviral and anti-inflammatory activity of budesonide against human rhinovirus infection mediated via autophagy activation[ANTIVIRAL RESEARCH,2018-02-03] -  Selective oncolytic effect in Epstein-Barr virus (EBV)-associated gastric carcinoma through efficient lytic induction by euphorbia extracts[JOURNAL OF FUNCTIONAL FOODS,2018-01-10]

특허(최근 5년)

-  모슬로플라본(mosloflavone) 화합물을 유효성분으로 함유하는 엔테로 바이러스에 기인한 질환의 예방 및 치료용 조성물[2016-07-21] -  오록실린(oroxylin) A 화합물을 유효성분으로 함유하는 엔테로 바이러스에 기인한 질환의 예방 및 치료용 조성물[2016-08-01] -  CX-4945를 유효성분으로 함유하는 퇴행성 뇌질환 예방 및 치료용약학적조성물[2017-02-03] -  GPR43의 활성평가법[2017-01-20] -  개산초 추출물을 함유하는 대사성 질환 예방 및 치료용 약학적조성물[2017-08-07] -  삼백초 추출물 및 이의 분획물로부터 분리된 화합물을 유효성분으로 함유하는 항바이러스용 약학적 조성물[2017-03-28] -  2-옥소-1,2,3,4-테트라하이드로피리미딘-5-카르복사미드유도체를 유효성분으로 함유하는 대사성 질환 예방 또는 치료용 약학적 조성물[2016-09-06] -  황금 추출물 및 이로부터 분리된 화합물을 유효성분으로 함유하는 엔테로 바이러스에 기인한 질환의 예방 및 치료용 조성물[2016-11-02] -  CX-4945를 유효성분으로 함유하는 스플라이싱 조절제[2016-02-03] -  디아실글리세롤 아실트랜스퍼레이즈 억제용 신규 아자인돌계 화합물 및 이의 이용[2016-02-15] -  신규한 인돌 유도체 또는 이의 약학적으로 허용가능한염, 이의 제조방법 및 이를 유효성분으로 함유하는 대사성 질환의 예방 또는 치료용 약학적 조성물[2014-12-09] -  삼백초 추출물 또는 이의 분획물을 유효성분으로 함유하는항바이러스용약학적조성물[2016-12-23] -  신규한 디아실글리세롤 아실트랜스퍼레이즈 2 억제 물질 및 이의 이용[2014-11-17] -  GPR43의 활성평가법[2015-05-26]

연구과제 수행 실적

신규 타겟기반 퇴행성 뇌질환 개선물질 검증 해외식물소재 기반 희귀 근육질환 개선물질 발굴 및 검증