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김미랑 교수

Mirang Kim

INFO

  • 소속캠퍼스한국생명공학연구원 스쿨
  • 전공 생명과학
    (기능유전체학)
  • 연락처042-879-8113
  • 출신전공기능유전체학
  • 학위박사
  • 최종출신대학과학기술연합대학원대학교
  • 이메일

연구분야

후성유전학

Epigenetics

대표연구실적

-  Inkyung Jung*, Seung-Kyoon Kim*, Mirang Kim*, Yong-Mahn Han, Yong Sung Kim, Dongsup Kim, and Daeyoup Lee. H2B mono-ubiquitylation is a 5?-enriched active transcription mark and determines exon-intron architecture in humans. Genome Research. 2012:22(6):1026-1035 -  Mirang Kim, Tae-Wook Kang, Han-Chul Lee, Yong-Mahn Han, Hyemin Kim, Hyoung Doo Shin, Hyun Sub Cheong, Daeyoup Lee, Seon-Young Kim, and Yong Sung Kim. Identification of DNA methylation markers for lineage commitment of in vitro hepatogenesis. Hum Mol Genet. 2011;20(14):2722-2733 -  Mirang Kim, Jeong-Hwan Kim, Hay-Ran Jang, Hwan-Mook Kim, Chang-Woo Lee, Seung-Moo Noh, Kyu-Sang Song, June-Sik Cho, Hyun-Yong Jeong, Yoonsoo Hahn, Young-Il Yeom, Hyang-Sook Yoo, and Yong Sung Kim. LRRC3B, encoding a leucine-rich repeat-containing protein, is a putative tumor suppressor gene in gastric cancer. Cancer Res. 2008;68(17): 7147-7155

논문(최근 5년)

-  Vitamin C facilitates dopamine neuron differentiation in fetal midbrain through TET1- and JMJD3-dependent epigenetic control manner.[ STEM CELLS,2015-04-01] -  Decrease of 5hmC in gastric cancers is associated with TET1 silencing due to with DNA methylation and bivalent histone marks at TET1 CpG island 3'-shore.[ONCOTARGET,2015-11-10] -  Cell-Free miR-27a, a Potential Diagnostic and Prognostic Biomarker for Gastric Cancer.[Genomics & Informatics,2015-09-01] -  Genomic and epigenomic heterogeneity in molecular subtypes of gastric cancer.[JOURNAL OF GASTROENTEROLOGY,2016-01-21] -  Integrated epigenomic analyses of enhancer as well as promoter regions in gastric cancer[ONCOTARGET,2016-05-03] -  Specific expression and methylation of SLIT1, SLIT2, SLIT3, and miR-218 in gastric cancer subtypes.[ INTERNATIONAL JOURNAL OF ONCOLOGY,2016-06-01] -  A late-lineage murine neutrophil precursor population exhibits dynamic changes during demand-adapted granulopoiesis.[SCIENTIFIC REPORTS,2017-06-06] -  Cyclin Y-mediated transcript profiling reveals several important functional pathways regulated by Cyclin Y in hippocampal neurons.[PLOS ONE,2017-02-27] -  DNA methylation: an epigenetic mark of cellular memory.[EXPERIMENTAL AND MOLECULAR MEDICINE,2017-04-28] -  Inflammation induces two types of inflammatory dendritic cellss in inflamed lymph nodes[EXPERIMENTAL AND MOLECULAR MEDICINE,2018-03-16] -  Dorsal and Ventral Hippocampus Differentiate in Functional Pathways and Differentially Associated with Neurological Disease-Related Genes during Pstnatal Development[FRONTIERS IN MOLECULAR NEUROSCIENCE,2017-10-16] -  Epigenetic silencing of BTB and CNC homology 2 and concerted promoter CpG methylation in gastric cancer[CANCER LETTERS,2014-09-01] -  Enhancer remodeling and microRNA alterations are associated with acquired resistance to ALK inhibitors[CANCER RESEARCH,2018-04-18] -  Vitamin C Promotes Astrocyte Differentiation Through DNA Hydroxymethylation.[STEM CELLS,2018-10-01] -  Epigenetic silencing of miR-1271 enhances MEK1 and TEAD4 expression in gastric cancer.[CANCER MEDICINE,2018-06-04] -  Enhancer Remodeling and MicroRNA Alterations Are Associated with Acquired Resistance to ALK Inhibitors.[CANCER RESEARCH,2018-06-15] -  Dorsal and Ventral Hippocampus Differentiate in Functional Pathways and Differentially Associate with Neurological Disease-Related Genes during Postnatal Development.[FRONTIERS IN MOLECULAR NEUROSCIENCE,2017-10-16] -  Inflammation induces two types of inflammatory dendritic cells in inflamed lymph nodes.[EXPERIMENTAL AND MOLECULAR MEDICINE,2018-03-16]

특허(최근 5년)

-  간세포 분화 탐지용 DNA 메틸화 마커 및 이를 이용한 탐지방법[2014-03-28] -  위암 특이적 유전자의 조기 탐지를 위한 메틸화 바이오마커[2015-03-31] -  마이크로RNA-10b를 유효성분으로함유하는 위암예방 및 치료용 조성물[2015-06-01]

연구과제 수행 실적

유전체 빅데이터 기반 난치성 질환 원천기술 개발사업 전사체 및 CRISPR 시스템 기반 약물작용점 연구