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김장환 교수

Janghwan Kim

INFO

  • 소속캠퍼스한국생명공학연구원 스쿨
  • 전공 생명과학
    (기능유전체학)
  • 연락처042-860-4478
  • 출신전공미생물 분자유전학
  • 학위박사
  • 최종출신대학충남대학교
  • 이메일
개인홈페이지

연구분야

줄기세포, 리프로그래밍, 직접교차분화, 신경계 분화, 세포운명전환

Stem cells, Reprogramming, Direct lineage reprogramming, Neural differentiation, Cell fate change

대표연구실적

-  Zhu S, ...Kim J.*, Ding S.* (2014) Small molecules enable OCT4-mediated direct reprogramming into expandable human neural stem cells. Cell Research 24(1): 126-129 *Corresponding -  Kim, J., et al. (2011) Direct reprogramming of mouse fibroblasts to neural progenitors. Proc. Natl. Acad. Sci. USA 108(19):7838-43 -  Kim, J., et al. (2003). A TRPV family ion channel required for hearing in Drosophila. Nature 424, 81-84

논문(최근 5년)

-  Synergistic antiviral activity of gemcitabine and ribavirin against enteroviruses [ ANTIVIRAL RESEARCH,2015-12-01] -  Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21(WAF1/CIP1) expression[MOLECULAR BRAIN,2015-09-18] -  Homogeneous generation of iDA neurons with high similarity to bona fide DA neurons using a drug inducible system[ BIOMATERIALS,2015-12-01] -  Integrative analysis of genes and miRNA alterations in human embryonic stem cells-derived neural cells after exposure to silver nanoparticles[TOXICOLOGY AND APPLIED PHARMACOLOGY,2016-05-15] -  Concurrent progress of reprogramming and gene correction to overcome therapeutic limitation of mutant ALK2-iPSC[ EXPERIMENTAL AND MOLECULAR MEDICINE,2016-06-03] -  Plasma-Treated Flexible Aminoclay-Decorated Electrospun Nanofibers for Neural Stem Cell Self-Renewal[ JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2016-02-01] -  Vertical nanocolumn-assisted pluripotent stem cell colony formation with minimal cell-penetration[NANOSCALE,2016-10-27] -  Distinctive genomic signature of neural and intestinal organoids from familial Parkinson’s disease patient-derive induced pluripotent stem cells[NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY,2017-02-24] -  Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids[NATURE COMMUNICATIONS,2018-08-02] -  Generation of gene-corrected iPSC line from Parkinson's disease patient iPSC line with alpha-SNCA A53T mutation[Stem Cell Research,2018-06-09] -  LRRK2 impairs autophagy by mediating phosphorylation of leucyl­tRNA synthetase[CELL BIOCHEMISTRY AND FUNCTION,2018-11-08] -  Transcriptome dynamics of human pluripotent stem cell-derived contracting cardiomyocytes using an embryoid body model with fetal bovine serum[MOLECULAR BIOSYSTEMS,2017-06-21] -  A Liver-specific Gene Expression Panel Predicts the Differentiation Status of in vitro Hepatocyte Models[HEPATOLOGY,2017-06-22] -  Inactivation of human DGAT2 by oxidative stress on cysteine residues[PLOS ONE,2017-07-11] -  Modelling APOE ?3/4 allele-associated sporadic Alzheimer's disease in an induced neuron[BRAIN,2017-07-03] -  Comparative analysis of human embryonic stem cell derived neural stem cells as an in vitro human model[INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE,2017-12-29] -  Selective oncolytic effect in Epstein-Barr virus (EBV)-associated gastric carcinoma through efficient lytic induction by euphorbia extracts[JOURNAL OF FUNCTIONAL FOODS,2018-01-12] -  In vitro and in vivo imaging and tracking of intestinal organoids from human-induced pluripotent stem cells[FASEB JOURNAL,2018-01-16] -  A novel and safe small molecule enhances hair follicle regeneration by facilitating metabolic reprogramming[EXPERIMENTAL AND MOLECULAR MEDICINE,2018-12-06] -  An antibody designed to improve adoptive NK-cell therapy inhibits pancreatic cancer progression in a murine model[CANCER IMMUNOLOGY RESEARCH,2019-02-07] -  Downregulation of PRMT1, a histone arginine methyltransferase, by sodium propionate induces cell apoptosis in colon cancer[ONCOLOGY REPORTS,2019-02-12]

특허(최근 5년)

-  기형종 형성을 통한 유도만능줄기세포 유도용 체세포의 무한 재생산 방법[2015-02-25] -  직접 리프로그래밍을 통한 유도 도파민성 전구세포 제조방법[2017-01-10] -  세포 스페로이드 배양기를 포함하는 세포 스페로이드 배양 시스템[2017-05-29] -  인공 장 및 그 제조 방법[2018-04-11] -  OCT4 저해용 조성물 및 이의 용도[2019-02-08]